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条件化恐惧复发的动物模型及相关神经机制
Alternative TitleAnimal models and related neurobiological mechanisms of conditioned fear relapse
付娟1,2; 郑希耕1; 刘正奎1
First Author付娟
2016
Source Publication心理科学进展
Correspondent Emailzhengxg@psych.ac.cn
ISSN1671-3710
Subtype期刊论文
Volume24Issue:10Pages:1592-1599
Contribution Rank1
Abstract

创伤后应激障碍(PTSD)受到国内外普遍关注,临床上常用的暴露疗法就是基于消退原理,但经过治疗的患者复发率仍然很高,这提示抑制复发可能是治疗创伤后应激障碍的关键问题。条件性恐惧复发的动物模型主要包括重建、续新和自发恢复,但是对续新的研究最多。前人的研究结果表明,恐惧复发具有异质性,但海马、前额叶与杏仁核三大脑区或许构成了共同的神经基础。文章从脑区机制及药理干预方面进行了综述,以期对基础研究和临床诊治提供参考。

Other Abstract

Post-traumatic stress disorder (PTSD)has received widespread concern at home and abroad. Exposure therapy, based on fear extinction, is commonly used in clinical practice. But the recurrence rate is still high after treatment. It suggests that the inhibition of fear relapse may be the key issue in the treatment of PTSD. Animal models of conditioned fear relapse include reinstatement, renewal, and spontaneous recovery, but most of the research has focused on renewal. Previous studies showed that fear relapse has heterogeneity, but the hippocampus, prefrontal cortex and amygdale may constitute common neural substrates. This article reviews brain region mechanisms and pharmacological intervention associated with conditioned fear relapse. It may provide reference for theoretical study and clinical treatment.

Keyword恐惧复发 动物模型 消退 神经生物学机制
Subject Area神经心理学
DOI10.3724/SP.J.1042.2016.01592
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization中国科学院知识创新工程项目(KSCX2-EW-J-8)、中 国科学院重点部署项目(KJZD-EW-L04-2)、山东省自 然科学基金项目(ZR2015CL025)、滨州市科学技术发 展计划项目(2014ZC0328)。
CSCD IDCSCD:5824789
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21108
Collection健康与遗传心理学研究室
Corresponding Author郑希耕
Affiliation1.中国科学院心理研究所心理健康重点实验室
2.滨州学院生命科学
Recommended Citation
GB/T 7714
付娟,郑希耕,刘正奎. 条件化恐惧复发的动物模型及相关神经机制[J]. 心理科学进展,2016,24(10):1592-1599.
APA 付娟,郑希耕,&刘正奎.(2016).条件化恐惧复发的动物模型及相关神经机制.心理科学进展,24(10),1592-1599.
MLA 付娟,et al."条件化恐惧复发的动物模型及相关神经机制".心理科学进展 24.10(2016):1592-1599.
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