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Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression
Lu, Jun1; Shao, Run-Hui1; Jin, Shu-Ying2; Hu, Li3; Tu, Ya1; Guo, Jian-You4
第一作者Lu, Jun
2017
发表期刊BRAIN RESEARCH BULLETIN
通讯作者邮箱tuyab@263.net ; guojy@psych.ac.cn
ISSN0361-9230
文章类型Article
卷号128期号:0页码:106-112
摘要

Depression is one of the most common psychiatric disorders. Chronic inflammatory response has been viewed as a key factor in depression. Acupuncture in Chinese medicine has been shown to be an effective treatment for depression. In the present study, we investigated the mechanism underlying antidepressant effect of acupuncture. The rats were subjected to chronic unpredictable mild stress (CUMS) for 28 days to induce depressive-like behaviors. Acupuncture treatment was applied once every other day during the 28-day stress period. The behavioral tests (body weight, sucrose consumption and locomotor activity) were performed. The expressions of nitric oxide (NO), prostaglandin E-2 (PGE(2)), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor kappa B (NF-B-K) were determined in the rat hippocampus and prefrontal cortex. CUMS induced depressive-like behavior in rats, which was alleviated by acupuncture treatment. The increased levels of NO, PGE(2), iNOS and COX-2 induced by CUMS, were all significantly decreased in the hippocampus and prefrontal cortex by acupuncture. Moreover, acupuncture markedly inhibited the activation of NF-B-K in rats. These findings showed that the antidepressant-like effect of acupuncture might be mediated by inhibition of inflammatory mediators via modulation of NF-kappa B in the brain regions. (C) 2016 Elsevier Inc. All rights reserved.

关键词Acupuncture Depression Chronic unpredictable stress Inflammatory response
DOI10.1016/j.brainresbull.2016.11.010
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(81102638 ; 81173334 ; 31371038)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000392354000015
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]FACTOR-KAPPA-B ; NITRIC-OXIDE SYNTHASE ; PREFRONTAL CORTEX ; MILD STRESS ; EXPRESSION ; COX-2 ; ANTIDEPRESSANT ; HIPPOCAMPUS ; BEHAVIOR ; CELECOXIB
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21141
专题中国科学院心理健康重点实验室
通讯作者Tu, Ya; Guo, Jian-You
作者单位1.Beijing Univ Chinese Med, Coll Acupuncture Moxibust & Tui Na, Beijing 100029, Peoples R China
2.Beijing Feng Tai Pu Huangyu Community Hlth Ctr, Beijing 100075, Peoples R China
3.Tangshan Feng Run Hosp TCM, Tangshan 064000, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Lu, Jun,Shao, Run-Hui,Jin, Shu-Ying,et al. Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression[J]. BRAIN RESEARCH BULLETIN,2017,128(0):106-112.
APA Lu, Jun,Shao, Run-Hui,Jin, Shu-Ying,Hu, Li,Tu, Ya,&Guo, Jian-You.(2017).Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression.BRAIN RESEARCH BULLETIN,128(0),106-112.
MLA Lu, Jun,et al."Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression".BRAIN RESEARCH BULLETIN 128.0(2017):106-112.
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