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Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression | |
Lu, Jun1; Shao, Run-Hui1; Jin, Shu-Ying2; Hu, Li3; Tu, Ya1; Guo, Jian-You4 | |
第一作者 | Lu, Jun |
通讯作者邮箱 | tuyab@263.net ; guojy@psych.ac.cn |
摘要 | Depression is one of the most common psychiatric disorders. Chronic inflammatory response has been viewed as a key factor in depression. Acupuncture in Chinese medicine has been shown to be an effective treatment for depression. In the present study, we investigated the mechanism underlying antidepressant effect of acupuncture. The rats were subjected to chronic unpredictable mild stress (CUMS) for 28 days to induce depressive-like behaviors. Acupuncture treatment was applied once every other day during the 28-day stress period. The behavioral tests (body weight, sucrose consumption and locomotor activity) were performed. The expressions of nitric oxide (NO), prostaglandin E-2 (PGE(2)), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor kappa B (NF-B-K) were determined in the rat hippocampus and prefrontal cortex. CUMS induced depressive-like behavior in rats, which was alleviated by acupuncture treatment. The increased levels of NO, PGE(2), iNOS and COX-2 induced by CUMS, were all significantly decreased in the hippocampus and prefrontal cortex by acupuncture. Moreover, acupuncture markedly inhibited the activation of NF-B-K in rats. These findings showed that the antidepressant-like effect of acupuncture might be mediated by inhibition of inflammatory mediators via modulation of NF-kappa B in the brain regions. (C) 2016 Elsevier Inc. All rights reserved. |
关键词 | Acupuncture Depression Chronic unpredictable stress Inflammatory response |
2017 | |
语种 | 英语 |
DOI | 10.1016/j.brainresbull.2016.11.010 |
发表期刊 | BRAIN RESEARCH BULLETIN |
ISSN | 0361-9230 |
卷号 | 128期号:0页码:106-112 |
期刊论文类型 | Article |
收录类别 | SCI ; SSCI |
WOS关键词 | FACTOR-KAPPA-B ; NITRIC-OXIDE SYNTHASE ; PREFRONTAL CORTEX ; MILD STRESS ; EXPRESSION ; COX-2 ; ANTIDEPRESSANT ; HIPPOCAMPUS ; BEHAVIOR ; CELECOXIB |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000392354000015 |
资助机构 | National Natural Science Foundation of China(81102638 ; 81173334 ; 31371038) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/21141 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Tu, Ya; Guo, Jian-You |
作者单位 | 1.Beijing Univ Chinese Med, Coll Acupuncture Moxibust & Tui Na, Beijing 100029, Peoples R China 2.Beijing Feng Tai Pu Huangyu Community Hlth Ctr, Beijing 100075, Peoples R China 3.Tangshan Feng Run Hosp TCM, Tangshan 064000, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Lu, Jun,Shao, Run-Hui,Jin, Shu-Ying,et al. Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression[J]. BRAIN RESEARCH BULLETIN,2017,128(0):106-112. |
APA | Lu, Jun,Shao, Run-Hui,Jin, Shu-Ying,Hu, Li,Tu, Ya,&Guo, Jian-You.(2017).Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression.BRAIN RESEARCH BULLETIN,128(0),106-112. |
MLA | Lu, Jun,et al."Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression".BRAIN RESEARCH BULLETIN 128.0(2017):106-112. |
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