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Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression
Yuan, Xiao-Ying1; Pang, Xiao-Wen1; Zhang, Guo-Qiang2; Guo, Jian-You3
第一作者Yuan, Xiao-Ying
2017
发表期刊PHOTOMEDICINE AND LASER SURGERY
ISSN1549-5418
文章类型Article
卷号35期号:1页码:49-56
摘要

Background: Salidroside is the major active component of Rhodiola rosea, a traditional Chinese herbal medicine used for protection against ultraviolet (UV) radiation. Objectives: This study investigated whether salidroside can protect skin from ultraviolet B (UVB)-induced oxidative damage in human immortalized HaCaT keratinocytes and the skin of guinea pigs. Methods: Using HaCaT cell models, the effects of salidroside on oxidative damage and possible regulatory factors [including NF-E2-related factor 2 (Nrf2), NAD(P) H-quinone oxidoreductase (NQO1), and heme oxygenase 1 (HO-1)] were examined. In addition, the regulatory effects of salidroside on apoptotic sunburn cells (SBCs) and 8-hydroxy-2'-deoxyguanosine (8-OHdG)-positive epidermal cells on UVB-exposed guinea pig skin were also investigated. Results: We found that salidroside pretreatment upregulated Nrf2 translocation to the nucleus and transcription activity in HaCaT cells, as reflected by the increased nuclear accumulation of Nrf2 as well as the gene and protein expression of downstream Nrf2 antioxidants, including NQO1 and HO-1. In addition, we also found that pretreatment with salidroside reactive oxygen species (ROS) in irradiated HaCaT cells. The oral administration of salidroside (0.1% w/w) to guinea pigs inhibited the UVB-mediated formation of apoptotic SBCs and 8-OHdG-positive epidermal cells in the skin of guinea pigs. Conclusions: Our results show that UVB-induced oxidative damage can be prevented by salidroside with upregulation of nuclear Nrf2 expression.

关键词photobiology photomedicine skin
DOI10.1089/pho.2016.4151
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81000706) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS研究方向Surgery
WOS类目Surgery
WOS记录号WOS:000391852400008
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ULTRAVIOLET-RADIATION ; SIGNALING PATHWAY ; RHODIOLA-ROSEA ; SKIN ; CELLS ; STRESS ; SULFORAPHANE ; RESPONSES ; GENES ; PHOTOCARCINOGENESIS
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21143
专题中国科学院心理健康重点实验室
作者单位1.Air Force Gen Hosp, Dept Dermatol, Beijing, Peoples R China
2.Hebei Med Univ, Dept Dermatol, Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Yuan, Xiao-Ying,Pang, Xiao-Wen,Zhang, Guo-Qiang,et al. Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression[J]. PHOTOMEDICINE AND LASER SURGERY,2017,35(1):49-56.
APA Yuan, Xiao-Ying,Pang, Xiao-Wen,Zhang, Guo-Qiang,&Guo, Jian-You.(2017).Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression.PHOTOMEDICINE AND LASER SURGERY,35(1),49-56.
MLA Yuan, Xiao-Ying,et al."Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression".PHOTOMEDICINE AND LASER SURGERY 35.1(2017):49-56.
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