PSYCH OpenIR  > 中国科学院心理健康重点实验室
Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression
Yuan, Xiao-Ying1; Pang, Xiao-Wen1; Zhang, Guo-Qiang2; Guo, Jian-You3
First AuthorYuan, Xiao-Ying
2017
Source PublicationPHOTOMEDICINE AND LASER SURGERY
ISSN1549-5418
SubtypeArticle
Volume35Issue:1Pages:49-56
Abstract

Background: Salidroside is the major active component of Rhodiola rosea, a traditional Chinese herbal medicine used for protection against ultraviolet (UV) radiation. Objectives: This study investigated whether salidroside can protect skin from ultraviolet B (UVB)-induced oxidative damage in human immortalized HaCaT keratinocytes and the skin of guinea pigs. Methods: Using HaCaT cell models, the effects of salidroside on oxidative damage and possible regulatory factors [including NF-E2-related factor 2 (Nrf2), NAD(P) H-quinone oxidoreductase (NQO1), and heme oxygenase 1 (HO-1)] were examined. In addition, the regulatory effects of salidroside on apoptotic sunburn cells (SBCs) and 8-hydroxy-2'-deoxyguanosine (8-OHdG)-positive epidermal cells on UVB-exposed guinea pig skin were also investigated. Results: We found that salidroside pretreatment upregulated Nrf2 translocation to the nucleus and transcription activity in HaCaT cells, as reflected by the increased nuclear accumulation of Nrf2 as well as the gene and protein expression of downstream Nrf2 antioxidants, including NQO1 and HO-1. In addition, we also found that pretreatment with salidroside reactive oxygen species (ROS) in irradiated HaCaT cells. The oral administration of salidroside (0.1% w/w) to guinea pigs inhibited the UVB-mediated formation of apoptotic SBCs and 8-OHdG-positive epidermal cells in the skin of guinea pigs. Conclusions: Our results show that UVB-induced oxidative damage can be prevented by salidroside with upregulation of nuclear Nrf2 expression.

Keywordphotobiology photomedicine skin
DOI10.1089/pho.2016.4151
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81000706) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS Research AreaSurgery
WOS SubjectSurgery
WOS IDWOS:000391852400008
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordULTRAVIOLET-RADIATION ; SIGNALING PATHWAY ; RHODIOLA-ROSEA ; SKIN ; CELLS ; STRESS ; SULFORAPHANE ; RESPONSES ; GENES ; PHOTOCARCINOGENESIS
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21143
Collection中国科学院心理健康重点实验室
Affiliation1.Air Force Gen Hosp, Dept Dermatol, Beijing, Peoples R China
2.Hebei Med Univ, Dept Dermatol, Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Xiao-Ying,Pang, Xiao-Wen,Zhang, Guo-Qiang,et al. Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression[J]. PHOTOMEDICINE AND LASER SURGERY,2017,35(1):49-56.
APA Yuan, Xiao-Ying,Pang, Xiao-Wen,Zhang, Guo-Qiang,&Guo, Jian-You.(2017).Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression.PHOTOMEDICINE AND LASER SURGERY,35(1),49-56.
MLA Yuan, Xiao-Ying,et al."Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression".PHOTOMEDICINE AND LASER SURGERY 35.1(2017):49-56.
Files in This Item:
File Name/Size DocType Version Access License
Salidroside's Protec(445KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yuan, Xiao-Ying]'s Articles
[Pang, Xiao-Wen]'s Articles
[Zhang, Guo-Qiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yuan, Xiao-Ying]'s Articles
[Pang, Xiao-Wen]'s Articles
[Zhang, Guo-Qiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yuan, Xiao-Ying]'s Articles
[Pang, Xiao-Wen]'s Articles
[Zhang, Guo-Qiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.