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A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging
Li, Juan1,2; Broster, Lucas S.2; Jicha, Gregory A.3,4; Munro, Nancy B.5; Schmitt, Frederick A.2,3,4; Abner, Erin3,6; Kryscio, Richard3,7,8; Smith, Charles D.3,4; Jiang, Yang2,3
First AuthorLi, Juan
2017-01-19
Source PublicationALZHEIMERS RESEARCH & THERAPY
Correspondent Emaillijuan@psych.ac.cn ; yjiang@uky.edu
ISSN1758-9193
SubtypeArticle
Volume9Issue:0Pages:1-10
Abstract

Background: Noninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce. Cognitive event-related potentials (ERPs) measure synchronized synaptic neural activity associated with a cognitive event. Loss of synapses is a hallmark of the neuropathology of early Alzheimer's disease (AD). In the present study, we tested the hypothesis that ERP responses during working memory retrieval discriminate aMCI from cognitively normal controls (NC) matched in age and education.

KeywordAmnestic mild cognitive impairment Alzheimer's disease Event-related potentials Working memory Early detection
DOI10.1186/s13195-016-0229-3
Indexed BySCI
Language英语
Funding OrganizationNational Science Foundation of China(31671157 ; Chinese Academy of Sciences ; State Administration of Foreign Experts Affairs (CAS/SAFEA) International Partnership Program for Creative Research Team(Y2CX131003) ; China Abroad Scholarship Fund ; Laboratory Directed Research and Development program of ORNL ; UT-Battelle LLC for the U.S. Department of Energy(DE-AC05-00OR22725) ; U.S. National Institutes of Health(P30AG028383 ; pilot grant from University of Kentucky Department of Behavioral Science ; 31470998 ; T32 AG 242-18 ; 31271108) ; UL1RR033173 ; UL1TR000117 ; TL1TR00015 ; P50AG05144 ; AG000986)
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000392149100001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordEVENT-RELATED POTENTIALS ; ALZHEIMERS ASSOCIATION WORKGROUPS ; WORKING-MEMORY ; DIAGNOSTIC GUIDELINES ; NATIONAL INSTITUTE ; NEURAL MECHANISMS ; DISEASE ; RECOMMENDATIONS ; NEUROPATHOLOGY ; PROGRESSION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21145
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Juan; Jiang, Yang
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Kentucky, Coll Med, Dept Behav Sci, Lexington, KY 40536 USA
3.Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA
4.Univ Kentucky, Dept Neurol, Coll Med, Lexington, KY 40536 USA
5.Oak Ridge Natl Lab, Oak Ridge, TN USA
6.Univ Kentucky, Coll Publ Hlth, Dept Epidemiol, Lexington, KY 40536 USA
7.Univ Kentucky, Dept Stat, Lexington, KY 40536 USA
8.Univ Kentucky, Dept Biostat, Coll Publ Hlth, Lexington, KY 40536 USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Juan,Broster, Lucas S.,Jicha, Gregory A.,et al. A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging[J]. ALZHEIMERS RESEARCH & THERAPY,2017,9(0):1-10.
APA Li, Juan.,Broster, Lucas S..,Jicha, Gregory A..,Munro, Nancy B..,Schmitt, Frederick A..,...&Jiang, Yang.(2017).A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging.ALZHEIMERS RESEARCH & THERAPY,9(0),1-10.
MLA Li, Juan,et al."A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging".ALZHEIMERS RESEARCH & THERAPY 9.0(2017):1-10.
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