A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging

doi:10.1186/s13195-016-0229-3

	A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging
	Li, Juan1,2 ; Broster, Lucas S.2; Jicha, Gregory A.3,4; Munro, Nancy B.5; Schmitt, Frederick A.2,3,4; Abner, Erin 3,6; Kryscio, Richard 3,7,8; Smith, Charles D.3,4; Jiang, Yang 2,3
第一作者	Li, Juan
通讯作者邮箱	lijuan@psych.ac.cn ; yjiang@uky.edu
摘要	Background: Noninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce. Cognitive event-related potentials (ERPs) measure synchronized synaptic neural activity associated with a cognitive event. Loss of synapses is a hallmark of the neuropathology of early Alzheimer's disease (AD). In the present study, we tested the hypothesis that ERP responses during working memory retrieval discriminate aMCI from cognitively normal controls (NC) matched in age and education.
关键词	Amnestic mild cognitive impairment Alzheimer's disease Event-related potentials Working memory Early detection
	2017-01-19
语种	英语
DOI	10.1186/s13195-016-0229-3
发表期刊	ALZHEIMERS RESEARCH & THERAPY
ISSN	1758-9193
卷号	9 期号:0 页码:1-10
期刊论文类型	Article
收录类别	SCI
WOS关键词	EVENT-RELATED POTENTIALS ; ALZHEIMERS ASSOCIATION WORKGROUPS ; WORKING-MEMORY ; DIAGNOSTIC GUIDELINES ; NATIONAL INSTITUTE ; NEURAL MECHANISMS ; DISEASE ; RECOMMENDATIONS ; NEUROPATHOLOGY ; PROGRESSION
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology ; Neurosciences
WOS记录号	WOS:000392149100001
资助机构	National Science Foundation of China(31671157 ; Chinese Academy of Sciences ; State Administration of Foreign Experts Affairs (CAS/SAFEA) International Partnership Program for Creative Research Team(Y2CX131003) ; China Abroad Scholarship Fund ; Laboratory Directed Research and Development program of ORNL ; UT-Battelle LLC for the U.S. Department of Energy(DE-AC05-00OR22725) ; U.S. National Institutes of Health(P30AG028383 ; pilot grant from University of Kentucky Department of Behavioral Science ; 31470998 ; T32 AG 242-18 ; 31271108) ; UL1RR033173 ; UL1TR000117 ; TL1TR00015 ; P50AG05144 ; AG000986)
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/21145
专题	中国科学院心理健康重点实验室
通讯作者	Li, Juan; Jiang, Yang
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Kentucky, Coll Med, Dept Behav Sci, Lexington, KY 40536 USA 3.Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA 4.Univ Kentucky, Dept Neurol, Coll Med, Lexington, KY 40536 USA 5.Oak Ridge Natl Lab, Oak Ridge, TN USA 6.Univ Kentucky, Coll Publ Hlth, Dept Epidemiol, Lexington, KY 40536 USA 7.Univ Kentucky, Dept Stat, Lexington, KY 40536 USA 8.Univ Kentucky, Dept Biostat, Coll Publ Hlth, Lexington, KY 40536 USA
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Li, Juan,Broster, Lucas S.,Jicha, Gregory A.,et al. A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging[J]. ALZHEIMERS RESEARCH & THERAPY,2017,9(0):1-10.
APA	Li, Juan.,Broster, Lucas S..,Jicha, Gregory A..,Munro, Nancy B..,Schmitt, Frederick A..,...&Jiang, Yang.(2017).A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging.ALZHEIMERS RESEARCH & THERAPY,9(0),1-10.
MLA	Li, Juan,et al."A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging".ALZHEIMERS RESEARCH & THERAPY 9.0(2017):1-10.

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