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A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging
Li, Juan1,2; Broster, Lucas S.2; Jicha, Gregory A.3,4; Munro, Nancy B.5; Schmitt, Frederick A.2,3,4; Abner, Erin3,6; Kryscio, Richard3,7,8; Smith, Charles D.3,4; Jiang, Yang2,3
第一作者Li, Juan
2017-01-19
发表期刊ALZHEIMERS RESEARCH & THERAPY
通讯作者邮箱lijuan@psych.ac.cn ; yjiang@uky.edu
ISSN1758-9193
文章类型Article
卷号9期号:0页码:1-10
摘要

Background: Noninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce. Cognitive event-related potentials (ERPs) measure synchronized synaptic neural activity associated with a cognitive event. Loss of synapses is a hallmark of the neuropathology of early Alzheimer's disease (AD). In the present study, we tested the hypothesis that ERP responses during working memory retrieval discriminate aMCI from cognitively normal controls (NC) matched in age and education.

关键词Amnestic mild cognitive impairment Alzheimer's disease Event-related potentials Working memory Early detection
DOI10.1186/s13195-016-0229-3
收录类别SCI
语种英语
项目资助者National Science Foundation of China(31671157 ; Chinese Academy of Sciences ; State Administration of Foreign Experts Affairs (CAS/SAFEA) International Partnership Program for Creative Research Team(Y2CX131003) ; China Abroad Scholarship Fund ; Laboratory Directed Research and Development program of ORNL ; UT-Battelle LLC for the U.S. Department of Energy(DE-AC05-00OR22725) ; U.S. National Institutes of Health(P30AG028383 ; pilot grant from University of Kentucky Department of Behavioral Science ; 31470998 ; T32 AG 242-18 ; 31271108) ; UL1RR033173 ; UL1TR000117 ; TL1TR00015 ; P50AG05144 ; AG000986)
WOS研究方向Neurosciences & Neurology
WOS类目Clinical Neurology ; Neurosciences
WOS记录号WOS:000392149100001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]EVENT-RELATED POTENTIALS ; ALZHEIMERS ASSOCIATION WORKGROUPS ; WORKING-MEMORY ; DIAGNOSTIC GUIDELINES ; NATIONAL INSTITUTE ; NEURAL MECHANISMS ; DISEASE ; RECOMMENDATIONS ; NEUROPATHOLOGY ; PROGRESSION
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21145
专题中国科学院心理健康重点实验室
通讯作者Li, Juan; Jiang, Yang
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Kentucky, Coll Med, Dept Behav Sci, Lexington, KY 40536 USA
3.Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA
4.Univ Kentucky, Dept Neurol, Coll Med, Lexington, KY 40536 USA
5.Oak Ridge Natl Lab, Oak Ridge, TN USA
6.Univ Kentucky, Coll Publ Hlth, Dept Epidemiol, Lexington, KY 40536 USA
7.Univ Kentucky, Dept Stat, Lexington, KY 40536 USA
8.Univ Kentucky, Dept Biostat, Coll Publ Hlth, Lexington, KY 40536 USA
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GB/T 7714
Li, Juan,Broster, Lucas S.,Jicha, Gregory A.,et al. A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging[J]. ALZHEIMERS RESEARCH & THERAPY,2017,9(0):1-10.
APA Li, Juan.,Broster, Lucas S..,Jicha, Gregory A..,Munro, Nancy B..,Schmitt, Frederick A..,...&Jiang, Yang.(2017).A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging.ALZHEIMERS RESEARCH & THERAPY,9(0),1-10.
MLA Li, Juan,et al."A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging".ALZHEIMERS RESEARCH & THERAPY 9.0(2017):1-10.
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