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Brain Formaldehyde is Related to Water Intake Behavior
Li, Ting1,6; Su, Tao1; He, Yingge1; Lu, Jihui5; Mo, Weichuan1; Wei, Yan1,3; He, Rongqiao1,2,4; Yan Wei; Rongqiao He
Source PublicationAging and Disease
Correspondent ;

A promising strategy for the prevention of Alzheimer's disease (AD) is the identification of agerelated changes that place the brain at risk for the disease. Additionally, AD is associated with chronic dehydration, and one of the significant changes that are known to result in metabolic dysfunction is an increase in the endogenous formaldehyde (FA) level. Here, we demonstrate that the levels of uric formaldehyde in AD patients were markedly increased compared with normal controls. The brain formaldehyde levels of wild-type C57 BL/6 mice increased with age, and these increases were followed by decreases in their drinking frequency and water intake. The serum arginine vasopressin (AVP) concentrations were also maintained at a high level in the 10-month-old mice. An intravenous injection of AVP into the tail induced decreases in the drinking frequency and water intake in the mice, and these decreases were associated with increases in brain formaldehyde levels. An ELISA assay revealed that the AVP injection increased both the protein level and the enzymatic activity of semicarbazide-sensitive amine oxidase (SSAO), which is an enzyme that produces formaldehyde. In contrast, the intraperitoneal injection of formaldehyde increased the serum AVP level by increasing the angiotensin II (ANG II) level, and this change was associated with a marked decrease in water intake behavior. These data suggest that the interaction between formaldehyde and AVP affects the water intake behaviors of mice. Furthermore, the highest concentration of formaldehyde in vivo was observed in the morning. Regular water intake is conducive to eliminating endogenous formaldehyde from the human body, particularly when water is consumed in the morning. Establishing good water intake habits not only effectively eliminates excess formaldehyde and other metabolic products but is also expected to yield valuable approaches to reducing the risk of AD prior to the onset of the disease.

Keywordformaldehyde water intake semicarbazide-sensitive amine oxidase arginine vasopressin behavior
Indexed BySCI
Funding Organization973-Projects(2012CB911004) ; Natural Scientific Foundation of China(NSFC 31270868 ; Queensland-Chinese Academy of Sciences Biotechnology Fund(GJHZ201302) ; CAS-20140909)
WOS Research AreaGeriatrics & Gerontology
WOS SubjectGeriatrics & Gerontology
WOS IDWOS:000392702800003
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYan Wei; Rongqiao He
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Southwest Med Univ, Luzhou 646000, Sichuan, Peoples R China
5.Beijing Geriatr Hosp, Beijing 100095, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Ting,Su, Tao,He, Yingge,et al. Brain Formaldehyde is Related to Water Intake Behavior[J]. Aging and Disease,2016,7(5):561-584.
APA Li, Ting.,Su, Tao.,He, Yingge.,Lu, Jihui.,Mo, Weichuan.,...&Rongqiao He.(2016).Brain Formaldehyde is Related to Water Intake Behavior.Aging and Disease,7(5),561-584.
MLA Li, Ting,et al."Brain Formaldehyde is Related to Water Intake Behavior".Aging and Disease 7.5(2016):561-584.
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