PSYCH OpenIR  > 中国科学院心理健康重点实验室
Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence
Zhang, Yu1,2,3; Shao, Feng4; Wang, Qiong4; Xie, Xi1,2; Wang, Weiwen1
2017
Source PublicationNEURAL PLASTICITY
ISSN2090-5904
SubtypeArticle
Issue0Pages:1-11
Abstract

Using a valid chronic mild stress (CMS) model of depression, we found that adolescent (postnatal days [PND] 28-41) CMS induced transient alterations in anhedonia that did not persist into adulthood after a 3-week recovery period. Previously stressed adult rats exhibited more immobility/despair behaviors in the forced swimming test and a greater number of trials to reach criterion in the set-shifting task, suggesting the impaired ability to cope with stressors and the cognitive flexibility that allows adaptation to dynamic environments during adulthood. In addition, adult rat exposure to adolescent CMS had a relatively inhibited activation in ERK signaling and downstream protein expression of phosphorylated cAMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex. Further correlation analysis demonstrated that immobility and set-shifting performance were positively correlated with the inhibition of ERK signaling. These results indicated adolescent CMS can be used as an effective stressor to model an increased predisposition to adult depression.

DOI10.1155/2017/9382797
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81471122 ; Chinese Academy of Sciences(KJZD-EW-L04) ; CAS Key Laboratory of Mental Health, Institute of Psychology ; 31470988)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000394002900001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordCHRONIC UNPREDICTABLE STRESS ; FORCED SWIMMING TEST ; ACTIVATED PROTEIN-KINASES ; MEDIAL PREFRONTAL CORTEX ; DEPRESSIVE-LIKE BEHAVIOR ; MATERNAL SEPARATION ; MAJOR DEPRESSION ; RESTRAINT STRESS ; SOCIAL-BEHAVIOR ; ANXIETY-LIKE
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21218
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Binzhou Med Univ, Sch Nursing, Yantai, Peoples R China
4.Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Yu,Shao, Feng,Wang, Qiong,et al. Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence[J]. NEURAL PLASTICITY,2017(0):1-11.
APA Zhang, Yu,Shao, Feng,Wang, Qiong,Xie, Xi,&Wang, Weiwen.(2017).Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence.NEURAL PLASTICITY(0),1-11.
MLA Zhang, Yu,et al."Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence".NEURAL PLASTICITY .0(2017):1-11.
Files in This Item:
File Name/Size DocType Version Access License
Neuroplastic Correla(1833KB)期刊论文出版稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Yu]'s Articles
[Shao, Feng]'s Articles
[Wang, Qiong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Yu]'s Articles
[Shao, Feng]'s Articles
[Wang, Qiong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Yu]'s Articles
[Shao, Feng]'s Articles
[Wang, Qiong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ab. .pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.