PSYCH OpenIR  > 中国科学院心理健康重点实验室
Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence
Zhang, Yu1,2,3; Shao, Feng4; Wang, Qiong4; Xie, Xi1,2; Wang, Weiwen1
第一作者Zhang, Yu ; Shao, Feng
心理所单位排序1
摘要

Using a valid chronic mild stress (CMS) model of depression, we found that adolescent (postnatal days [PND] 28-41) CMS induced transient alterations in anhedonia that did not persist into adulthood after a 3-week recovery period. Previously stressed adult rats exhibited more immobility/despair behaviors in the forced swimming test and a greater number of trials to reach criterion in the set-shifting task, suggesting the impaired ability to cope with stressors and the cognitive flexibility that allows adaptation to dynamic environments during adulthood. In addition, adult rat exposure to adolescent CMS had a relatively inhibited activation in ERK signaling and downstream protein expression of phosphorylated cAMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex. Further correlation analysis demonstrated that immobility and set-shifting performance were positively correlated with the inhibition of ERK signaling. These results indicated adolescent CMS can be used as an effective stressor to model an increased predisposition to adult depression.

2017
DOI10.1155/2017/9382797
发表期刊NEURAL PLASTICITY
ISSN2090-5904
期号0页码:1-11
收录类别SCI
WOS关键词CHRONIC UNPREDICTABLE STRESS ; FORCED SWIMMING TEST ; ACTIVATED PROTEIN-KINASES ; MEDIAL PREFRONTAL CORTEX ; DEPRESSIVE-LIKE BEHAVIOR ; MATERNAL SEPARATION ; MAJOR DEPRESSION ; RESTRAINT STRESS ; SOCIAL-BEHAVIOR ; ANXIETY-LIKE
WOS标题词Science & Technology ; Life Sciences & Biomedicine
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000394002900001
WOS分区Q3
资助机构National Natural Science Foundation of China(81471122 ; Chinese Academy of Sciences(KJZD-EW-L04) ; CAS Key Laboratory of Mental Health, Institute of Psychology ; 31470988)
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21218
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Binzhou Med Univ, Sch Nursing, Yantai, Peoples R China
4.Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China
第一作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Zhang, Yu,Shao, Feng,Wang, Qiong,et al. Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence[J]. NEURAL PLASTICITY,2017(0):1-11.
APA Zhang, Yu,Shao, Feng,Wang, Qiong,Xie, Xi,&Wang, Weiwen.(2017).Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence.NEURAL PLASTICITY(0),1-11.
MLA Zhang, Yu,et al."Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence".NEURAL PLASTICITY .0(2017):1-11.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Neuroplastic Correla(1833KB)期刊论文出版稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Yu]的文章
[Shao, Feng]的文章
[Wang, Qiong]的文章
百度学术
百度学术中相似的文章
[Zhang, Yu]的文章
[Shao, Feng]的文章
[Wang, Qiong]的文章
必应学术
必应学术中相似的文章
[Zhang, Yu]的文章
[Shao, Feng]的文章
[Wang, Qiong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。