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Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence
Zhang, Yu1,2,3; Shao, Feng4; Wang, Qiong4; Xie, Xi1,2; Wang, Weiwen1
2017
发表期刊NEURAL PLASTICITY
ISSN2090-5904
文章类型Article
期号0页码:1-11
摘要

Using a valid chronic mild stress (CMS) model of depression, we found that adolescent (postnatal days [PND] 28-41) CMS induced transient alterations in anhedonia that did not persist into adulthood after a 3-week recovery period. Previously stressed adult rats exhibited more immobility/despair behaviors in the forced swimming test and a greater number of trials to reach criterion in the set-shifting task, suggesting the impaired ability to cope with stressors and the cognitive flexibility that allows adaptation to dynamic environments during adulthood. In addition, adult rat exposure to adolescent CMS had a relatively inhibited activation in ERK signaling and downstream protein expression of phosphorylated cAMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex. Further correlation analysis demonstrated that immobility and set-shifting performance were positively correlated with the inhibition of ERK signaling. These results indicated adolescent CMS can be used as an effective stressor to model an increased predisposition to adult depression.

DOI10.1155/2017/9382797
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81471122 ; Chinese Academy of Sciences(KJZD-EW-L04) ; CAS Key Laboratory of Mental Health, Institute of Psychology ; 31470988)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000394002900001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]CHRONIC UNPREDICTABLE STRESS ; FORCED SWIMMING TEST ; ACTIVATED PROTEIN-KINASES ; MEDIAL PREFRONTAL CORTEX ; DEPRESSIVE-LIKE BEHAVIOR ; MATERNAL SEPARATION ; MAJOR DEPRESSION ; RESTRAINT STRESS ; SOCIAL-BEHAVIOR ; ANXIETY-LIKE
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21218
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Binzhou Med Univ, Sch Nursing, Yantai, Peoples R China
4.Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China
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GB/T 7714
Zhang, Yu,Shao, Feng,Wang, Qiong,et al. Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence[J]. NEURAL PLASTICITY,2017(0):1-11.
APA Zhang, Yu,Shao, Feng,Wang, Qiong,Xie, Xi,&Wang, Weiwen.(2017).Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence.NEURAL PLASTICITY(0),1-11.
MLA Zhang, Yu,et al."Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence".NEURAL PLASTICITY .0(2017):1-11.
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