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Sex Matters: Hippocampal Volume Predicts Individual Differences in Associative Memory in Cognitively Normal Older Women but Not Men
Zheng, Zhiwei1,2; Li, Rui1,2,3; Xiao, Fengqiu4; He, Rongqiao5; Zhang, Shouzi6; Li, Juan1,2,3,5
2017-03-06
Source PublicationFRONTIERS IN HUMAN NEUROSCIENCE
ISSN1662-5161
SubtypeArticle
Volume11
AbstractThe hippocampus plays a prominent role in associative memory by supporting relational binding and recollection processes. Structural atrophy in the hippocampus is likely to induce associative memory deficits in older adults. Previous studies have primarily focused on average age-related differences in hippocampal structure and memory performance. To date, however, it remains unclear whether individual differences in hippocampal morphometry underlie differential associative memory performance, and whether there are sex differences in the structural correlates of associative memory in healthy older adults. Here, we used voxel-based morphometry (VBM) to examine the extent to which gray matter volume (GMV) of the hippocampus predicts associative memory performance in cognitively normal older adults. Seventy-one participants completed a cued recall paired-associative learning test (PALT), which consists of novel associations and semantically related associations, and underwent magnetic resonance imaging (MRI). We observed worse associative memory performance and larger variability for novel associations than for semantically related associations. The VBM results revealed that higher scores on associative memory for novel associations were related to greater hippocampal GMV across all older adults. When considering men and women separately, the correlation between hippocampal GMV and associative memory performance for novel associations reached significance only in older women. These findings suggest that hippocampal structural volumes may predict individual differences in novel associative memory in older women but not men.
Keywordassociative memory sex differences hippocampus voxel-based morphometry (VBM) elderly
DOI10.3389/fnhum.2017.00093
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31271108 ; National Science and Technology Pillar Program of China(2009BAI77B03) ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program(TSS-2015-06) ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences(Y5CX131005) ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2015ZG06) ; 31470998 ; 31671157)
WOS Research AreaNeurosciences & Neurology ; Psychology
WOS SubjectNeurosciences ; Psychology
WOS IDWOS:000395434700001
WOS HeadingsScience & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS KeywordMEDIAL TEMPORAL-LOBE ; AGE-RELATED-CHANGES ; HEALTHY-YOUNG ADULTS ; LIFE-SPAN ; EPISODIC MEMORY ; BRAIN STRUCTURE ; ALZHEIMERS-DISEASE ; CORTICAL THICKNESS ; RECOGNITION MEMORY ; DEFICIT HYPOTHESIS
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21238
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
4.China Natl Childrens Ctr, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
6.Beijing Geriatr Hosp, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Zhiwei,Li, Rui,Xiao, Fengqiu,et al. Sex Matters: Hippocampal Volume Predicts Individual Differences in Associative Memory in Cognitively Normal Older Women but Not Men[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2017,11.
APA Zheng, Zhiwei,Li, Rui,Xiao, Fengqiu,He, Rongqiao,Zhang, Shouzi,&Li, Juan.(2017).Sex Matters: Hippocampal Volume Predicts Individual Differences in Associative Memory in Cognitively Normal Older Women but Not Men.FRONTIERS IN HUMAN NEUROSCIENCE,11.
MLA Zheng, Zhiwei,et al."Sex Matters: Hippocampal Volume Predicts Individual Differences in Associative Memory in Cognitively Normal Older Women but Not Men".FRONTIERS IN HUMAN NEUROSCIENCE 11(2017).
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