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Aberrant development of intrinsic brain activity in a rat model of caregiver maltreatment of offspring
Yan, C-G1,2,3,4; Rincon-Cortes, M.3,5; Raineki, C.3,5; Sarro, E.5; Colcombe, S.4; Guilfoyle, D. N.4; Yang, Z.4,6; Gerum, S.4; Biswal, B. B.4,7; Milham, M. P.4,6; Sullivan, R. M.3,5; Castellanos, F. X.3,4
2017-01-17
Source PublicationTRANSLATIONAL PSYCHIATRY
ISSN2158-3188
SubtypeArticle
Volume7Issue:0Pages:1-9
Abstract

Caregiver maltreatment induces vulnerability to later-life psychopathology. Clinical and preclinical evidence suggest changes in prefrontal and limbic circuitry underlie this susceptibility. We examined this question using a rat model of maternal maltreatment and methods translated from humans, resting-state functional magnetic resonance imaging (R-fMRI). Rat pups were reared by mothers provided with insufficient or abundant bedding for nest building from postnatal (PN) days 8 to 12 and underwent behavioral assessments of affect-related behaviors (forced swim, sucrose preference and social interaction) in adolescence (PN45) and early adulthood (PN60). R-fMRI sessions were conducted under light anesthesia at both ages. Offspring reared with insufficient bedding (that is, maltreated) displayed enduring negative affective behaviors. Amygdala-prefrontal cortex (PFC) functional connectivity increased significantly from adolescence to adulthood in controls, but not in maltreated animals. We computed the fractional amplitude of low-frequency fluctuations (fALFF), an index of intrinsic brain activity, and found that fALFF in medial prefrontal cortex and anterior cingulate cortex (MPFC/ACC) increased significantly with age in controls but remained unchanged in maltreated animals during adolescence and adulthood. We used a seed-based analysis to explore changes in functional connectivity between this region and the whole brain. Compared with controls, maltreated animals demonstrated reduced functional connectivity between MPFC/ACC and left caudate/putamen across both ages. Functional connectivity between MPFC/ACC and right caudate/putamen showed a group by age interaction: decreased in controls but increased in maltreated animals. These data suggest that maltreatment induces vulnerability to psychopathology and is associated with differential developmental trajectories of prefrontal and subcortical circuits underlying affect regulation.

DOI10.1038/tp.2016.276
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNIH(R33MH086952 ; National Natural Science Foundation of China(81671774) ; Hundred Talents Program of the Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission(Z161100000216152) ; 1S10RR023534)
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000396451500005
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordEARLY-LIFE STRESS ; MEDIAL PREFRONTAL CORTEX ; STATE FUNCTIONAL CONNECTIVITY ; GLOBAL SIGNAL REGRESSION ; DEPRESSION-LIKE BEHAVIOR ; EARLY ADVERSE EXPERIENCE ; CROSS-SPECIES ANALYSIS ; CHILD-ABUSE ; ADOLESCENT DEPRESSION ; MATERNAL MALTREATMENT
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21254
Collection认知与发展心理学研究室
Affiliation1.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
3.NYU, Sch Med, Langone Med Ctr, Dept Child & Adolescent Psychiat, 1 Pk Ave,7th Floor, New York, NY 10016 USA
4.Nathan S Kline Inst Psychiat Res, Ctr Biomed Imaging & Neuromodulat, Orangeburg, NY USA
5.Nathan S Kline Inst Psychiat Res, Emot Brain Inst, Orangeburg, NY USA
6.Child Mind Inst, Ctr Dev Brain, New York, NY USA
7.New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA
Recommended Citation
GB/T 7714
Yan, C-G,Rincon-Cortes, M.,Raineki, C.,et al. Aberrant development of intrinsic brain activity in a rat model of caregiver maltreatment of offspring[J]. TRANSLATIONAL PSYCHIATRY,2017,7(0):1-9.
APA Yan, C-G.,Rincon-Cortes, M..,Raineki, C..,Sarro, E..,Colcombe, S..,...&Castellanos, F. X..(2017).Aberrant development of intrinsic brain activity in a rat model of caregiver maltreatment of offspring.TRANSLATIONAL PSYCHIATRY,7(0),1-9.
MLA Yan, C-G,et al."Aberrant development of intrinsic brain activity in a rat model of caregiver maltreatment of offspring".TRANSLATIONAL PSYCHIATRY 7.0(2017):1-9.
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