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Neural signatures of phonological deficits in Chinese developmental dyslexia
Cao, Fan1; Yan, Xin1; Wang, Zhao2; Liu, Yanni3; Wang, Jin4; Spray, Gregory J.1; Deng, Yuan4
2017-02-01
Source PublicationNEUROIMAGE
ISSN1053-8119
SubtypeArticle
Volume146Issue:0Pages:301-311
Abstract

There has been debate on whether phonological deficits explain reading difficulty in Chinese, since Chinese is a logographic language which does not employ grapheme-phoneme-correspondence rules and remote memorization seems to be the main method to acquire reading. In the current study, we present neuroimaging evidence that the phonological deficit is also a signature of Chinese dyslexia. Specifically, we found that Chinese children with dyslexia (DD) showed reduced brain activation in the left dorsal inferior frontal gyrus (dIFG) when compared to both age-matched controls (AC) and reading-matched controls (RC) during an auditory rhyming judgment task. This suggests that the phonological processing deficit in this region may be a signature of dyslexia in Chinese, rather than a difference due to task performance or reading ability, which was matched on DD and RC. At exactly the same region of the left dIFG, we found a positive correlation between brain activation and reading skill in DD, suggesting that the phonological deficit is associated with the severity of dyslexia. We also found increased brain activation in the right precentral gyros in DD than both AC and RC, suggesting a compensation of reliance on articulation. Functional connectivity analyses revealed that DD had a weaker connection between the left superior temporal gyrus (STG) and fusiform gyrus (FG) than the two control groups, suggesting that the reduced connection between phonology and orthography is another neural signature of dyslexia. In contrast, DD showed greater connectivity between the left dIFG and the left inferior parietal lobule (IPL) than both control groups, suggesting a reduced segregation between the language network and default mode network in dyslexic children. We also found that connectivity between the left STG and the left dIFG was sensitive to task performance and/or reading skill rather than being dyslexic or not, because AC was greater than both RC and DD, while the connectivity between the left middle occipital gyrus (MOG) and left STG was sensitive to age, because both AC and DD were greater than RC. In summary, our study provides the very first neurological evidence of phonological deficits in Chinese developmental dyslexia and we successfully distinguished variations of brain activity/functional connectivity due to age, performance, and dyslexia by comparing AC, RC, and DD.

KeywordDyslexia fMRI Phonological deficit Reading-control
DOI10.1016/j.neuroimage.2016.11.051
Indexed BySCI ; SSCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000394560700028
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDEFAULT MODE NETWORK ; VENTRAL OCCIPITOTEMPORAL CORTEX ; WORD FORM AREA ; EFFECTIVE CONNECTIVITY ; BRAIN CONNECTIVITY ; RESTING-STATE ; FUNCTIONAL CONNECTIVITY ; READING DIFFICULTIES ; MANDARIN CHINESE ; WRITING SYSTEM
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21298
Collection认知与发展心理学研究室
Affiliation1.Michigan State Univ, Communicat Sci & Disorders, E Lansing, MI 48824 USA
2.Beijing Normal Univ, Beijing, Peoples R China
3.Univ Michigan, Ann Arbor, MI 48109 USA
4.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Cao, Fan,Yan, Xin,Wang, Zhao,et al. Neural signatures of phonological deficits in Chinese developmental dyslexia[J]. NEUROIMAGE,2017,146(0):301-311.
APA Cao, Fan.,Yan, Xin.,Wang, Zhao.,Liu, Yanni.,Wang, Jin.,...&Deng, Yuan.(2017).Neural signatures of phonological deficits in Chinese developmental dyslexia.NEUROIMAGE,146(0),301-311.
MLA Cao, Fan,et al."Neural signatures of phonological deficits in Chinese developmental dyslexia".NEUROIMAGE 146.0(2017):301-311.
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