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Dynamic Expression Changes in the Transcriptome oft he Prefrontal Cortex after Repeated Exposure to Cocaine in Mice
Li, Mingzhen1,2; Xu, Peng3; Xu, Yanhua1; Teng, Huajing4,5; Tian, Weiping1; Du, Quansheng1,6; Zhao, Mei1,5; Mei Zhao
第一作者Xu, Peng
2017-03-23
发表期刊FRONTIERS IN PHARMACOLOGY
通讯作者邮箱zhaomei@psych.ac.cn
ISSN1663-9812
文章类型Article
卷号8期号:0页码:1-10
摘要

Prefrontal cortex (PFC)-dependent functions, such as executive function, explicit learning, and memory, are negatively affected in cocaine abusers and experimental animal models of cocaine treatment. However, its molecular mechanisms are less understood. In the present study, we performed transcriptome profiling of the dynamic changes in the PFC after repeated cocaine administration in mice. We found 463, 14, and 535 differentially expressed genes (DEGs) at 2 h, 24 h, and 7 days, respectively, after the withdrawal of chronic cocaine treatment. Time-series correlation analysis identified 5 clusters of statistically significant expression patterns. The expression levels of DEGs in Clusters 1 and 5 exhibited a gradual or fluctuant decrease, Cluster 2 exhibited an initial increase followed by a decrease or return to the baseline level, and Clusters 3 and 4 exhibited a fluctuant increase in the expression of DEGs. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that genes related to oxidative phosphorylation, ribosomes, and neurodegenerative disorder were enriched in Cluster 1; genes related to the mitogen activated protein kinase (MAPK), transforming growth factor (TGF)-beta, insulin signaling, and circadian pathways were enriched in Cluster 2; genes related to plasticity-related pathways were enriched in Clusters 3 and 4; and genes related to the proteasome were enriched in Cluster 5. Our results suggest that maladaptive neural plasticity associated with psychostimulant dependence may be an ongoing degenerative process with dynamic changes in the gene network at different stages of withdrawal. Furthermore, it could be helpful to develop new therapeutic approaches according to different periods of abstinence.

关键词prefrontalcortex(PFC) transcriptome cocaine addiction withdrawal
DOI10.3389/fphar.2017.00142
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(30870821 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; 91132728)
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000397166600001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]MOUSE NUCLEUS-ACCUMBENS ; ADULT-RAT BRAIN ; GENE-EXPRESSION ; DRUG-ADDICTION ; CIRCADIAN GENES ; RNA-SEQ ; PLASTICITY ; REWARD ; SENSITIZATION ; MECHANISMS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21304
专题中国科学院心理健康重点实验室
通讯作者Mei Zhao
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental, Beijing, Peoples R China
2.Beijing Ctr Phys & Chem Anal, Beijing, Peoples R China
3.Minist Publ Secur, Drug Intelligence & Forens Ctr, Beijing, Peoples R China
4.Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Natl Nat Sci Fdn China, Dept Life Sci, Beijing, Peoples R China
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Li, Mingzhen,Xu, Peng,Xu, Yanhua,et al. Dynamic Expression Changes in the Transcriptome oft he Prefrontal Cortex after Repeated Exposure to Cocaine in Mice[J]. FRONTIERS IN PHARMACOLOGY,2017,8(0):1-10.
APA Li, Mingzhen.,Xu, Peng.,Xu, Yanhua.,Teng, Huajing.,Tian, Weiping.,...&Mei Zhao.(2017).Dynamic Expression Changes in the Transcriptome oft he Prefrontal Cortex after Repeated Exposure to Cocaine in Mice.FRONTIERS IN PHARMACOLOGY,8(0),1-10.
MLA Li, Mingzhen,et al."Dynamic Expression Changes in the Transcriptome oft he Prefrontal Cortex after Repeated Exposure to Cocaine in Mice".FRONTIERS IN PHARMACOLOGY 8.0(2017):1-10.
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