PSYCH OpenIR  > 中国科学院心理健康重点实验室
Dynamic Expression Changes in the Transcriptome oft he Prefrontal Cortex after Repeated Exposure to Cocaine in Mice
Li, Mingzhen1,2; Xu, Peng3; Xu, Yanhua1; Teng, Huajing4,5; Tian, Weiping1; Du, Quansheng1,6; Zhao, Mei1,5; Mei Zhao
First AuthorXu, Peng
2017-03-23
Source PublicationFRONTIERS IN PHARMACOLOGY
Correspondent Emailzhaomei@psych.ac.cn
ISSN1663-9812
SubtypeArticle
Volume8Issue:0Pages:1-10
Abstract

Prefrontal cortex (PFC)-dependent functions, such as executive function, explicit learning, and memory, are negatively affected in cocaine abusers and experimental animal models of cocaine treatment. However, its molecular mechanisms are less understood. In the present study, we performed transcriptome profiling of the dynamic changes in the PFC after repeated cocaine administration in mice. We found 463, 14, and 535 differentially expressed genes (DEGs) at 2 h, 24 h, and 7 days, respectively, after the withdrawal of chronic cocaine treatment. Time-series correlation analysis identified 5 clusters of statistically significant expression patterns. The expression levels of DEGs in Clusters 1 and 5 exhibited a gradual or fluctuant decrease, Cluster 2 exhibited an initial increase followed by a decrease or return to the baseline level, and Clusters 3 and 4 exhibited a fluctuant increase in the expression of DEGs. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that genes related to oxidative phosphorylation, ribosomes, and neurodegenerative disorder were enriched in Cluster 1; genes related to the mitogen activated protein kinase (MAPK), transforming growth factor (TGF)-beta, insulin signaling, and circadian pathways were enriched in Cluster 2; genes related to plasticity-related pathways were enriched in Clusters 3 and 4; and genes related to the proteasome were enriched in Cluster 5. Our results suggest that maladaptive neural plasticity associated with psychostimulant dependence may be an ongoing degenerative process with dynamic changes in the gene network at different stages of withdrawal. Furthermore, it could be helpful to develop new therapeutic approaches according to different periods of abstinence.

Keywordprefrontalcortex(PFC) transcriptome cocaine addiction withdrawal
DOI10.3389/fphar.2017.00142
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(30870821 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; 91132728)
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000397166600001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordMOUSE NUCLEUS-ACCUMBENS ; ADULT-RAT BRAIN ; GENE-EXPRESSION ; DRUG-ADDICTION ; CIRCADIAN GENES ; RNA-SEQ ; PLASTICITY ; REWARD ; SENSITIZATION ; MECHANISMS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21304
Collection中国科学院心理健康重点实验室
Corresponding AuthorMei Zhao
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental, Beijing, Peoples R China
2.Beijing Ctr Phys & Chem Anal, Beijing, Peoples R China
3.Minist Publ Secur, Drug Intelligence & Forens Ctr, Beijing, Peoples R China
4.Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Natl Nat Sci Fdn China, Dept Life Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li, Mingzhen,Xu, Peng,Xu, Yanhua,et al. Dynamic Expression Changes in the Transcriptome oft he Prefrontal Cortex after Repeated Exposure to Cocaine in Mice[J]. FRONTIERS IN PHARMACOLOGY,2017,8(0):1-10.
APA Li, Mingzhen.,Xu, Peng.,Xu, Yanhua.,Teng, Huajing.,Tian, Weiping.,...&Mei Zhao.(2017).Dynamic Expression Changes in the Transcriptome oft he Prefrontal Cortex after Repeated Exposure to Cocaine in Mice.FRONTIERS IN PHARMACOLOGY,8(0),1-10.
MLA Li, Mingzhen,et al."Dynamic Expression Changes in the Transcriptome oft he Prefrontal Cortex after Repeated Exposure to Cocaine in Mice".FRONTIERS IN PHARMACOLOGY 8.0(2017):1-10.
Files in This Item:
File Name/Size DocType Version Access License
Dynamic Expression C(1262KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Mingzhen]'s Articles
[Xu, Peng]'s Articles
[Xu, Yanhua]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Mingzhen]'s Articles
[Xu, Peng]'s Articles
[Xu, Yanhua]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Mingzhen]'s Articles
[Xu, Peng]'s Articles
[Xu, Yanhua]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Dynamic Expression Changes in the Transcriptome oft he Prefrontal Cortex after Repeated Exposure to Cocaine in Mice.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.