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Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder
Gan, J.1,2; Zhong, M.3; Fan, J.1,2; Liu, W.1,2; Niu, C.1,2; Cai, S.4; Zou, L.5,6; Wang, Ya5,6; Wang, Yi5,6; Tan, C.4; Chan, R. C. K.5,6; Zhu, X.1,2
第一作者Gan, J.
2017-03-14
发表期刊TRANSLATIONAL PSYCHIATRY
通讯作者邮箱xiongzhaozhu@163.com
ISSN2158-3188
文章类型Article
卷号7期号:0页码:e1062
摘要

Obsessive-compulsive disorder (OCD) is a complex and severe psychiatric disorder whose pathogenesis is not fully understood. Recent studies have shown white matter (WM) alterations in adults with OCD, but the results have been inconsistent. The present study investigated WM structure in OCD patients with the hypothesis that large-scale brain networks may be disrupted in OCD. A total of 24 patients with OCD and 23 healthy controls (HCs) were scanned with diffusion tensor imaging. A tract-based spatial statistics (TBSS) approach was used to detect differences across the whole brain in patients with OCD vs HCs; post hoc fiber tractography was applied to characterize developmental differences between the two groups. Relative to HCs, patients with OCD had lower fractional anisotropy (FA) values in the corpus callosum (CC), left anterior corona radiata (ACR), left superior corona radiata (SCR) and left superior longitudinal fasciculus (SLF), and higher radial diffusivity in the genu and body of CC. Among the TBSS de-projected region of interest results, compared with HCs, patients with OCD showed lower of the mean FA values of fiber bundles passing though the SLF, and shorter lengths of ACR, SCR and CC. In conclusion, this study provides novel evidence of widespread microstructural alterations in OCD and suggests that OCD may involve abnormalities affecting a broader network of regions than commonly believed.

DOI10.1038/tp.2017.22
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收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(81371487) ; National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2012BAI36B01)
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000397229000007
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]DIFFUSION-TENSOR ; FRACTIONAL ANISOTROPY ; SPATIAL STATISTICS ; IN-VIVO ; MICROSTRUCTURE ; ADOLESCENTS ; RELATIVES
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21322
专题中国科学院心理健康重点实验室
作者单位1.Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha 410011, Hunan, Peoples R China
2.Cent S Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China
3.South China Normal Univ, Sch Psychol, Ctr Studies Psychol Applicat, Guangzhou, Guangdong, Peoples R China
4.Cent S Univ, Xiangya Hosp 2, Dept Radiol, Changsha, Hunan, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
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GB/T 7714
Gan, J.,Zhong, M.,Fan, J.,et al. Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder[J]. TRANSLATIONAL PSYCHIATRY,2017,7(0):e1062.
APA Gan, J..,Zhong, M..,Fan, J..,Liu, W..,Niu, C..,...&Zhu, X..(2017).Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder.TRANSLATIONAL PSYCHIATRY,7(0),e1062.
MLA Gan, J.,et al."Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder".TRANSLATIONAL PSYCHIATRY 7.0(2017):e1062.
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