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Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder | |
Gan, J.1,2; Zhong, M.3; Fan, J.1,2; Liu, W.1,2; Niu, C.1,2; Cai, S.4; Zou, L.5,6; Wang, Ya5,6; Wang, Yi5,6; Tan, C.4; Chan, R. C. K.5,6; Zhu, X.1,2 | |
第一作者 | Gan, J. |
通讯作者邮箱 | xiongzhaozhu@163.com |
摘要 | Obsessive-compulsive disorder (OCD) is a complex and severe psychiatric disorder whose pathogenesis is not fully understood. Recent studies have shown white matter (WM) alterations in adults with OCD, but the results have been inconsistent. The present study investigated WM structure in OCD patients with the hypothesis that large-scale brain networks may be disrupted in OCD. A total of 24 patients with OCD and 23 healthy controls (HCs) were scanned with diffusion tensor imaging. A tract-based spatial statistics (TBSS) approach was used to detect differences across the whole brain in patients with OCD vs HCs; post hoc fiber tractography was applied to characterize developmental differences between the two groups. Relative to HCs, patients with OCD had lower fractional anisotropy (FA) values in the corpus callosum (CC), left anterior corona radiata (ACR), left superior corona radiata (SCR) and left superior longitudinal fasciculus (SLF), and higher radial diffusivity in the genu and body of CC. Among the TBSS de-projected region of interest results, compared with HCs, patients with OCD showed lower of the mean FA values of fiber bundles passing though the SLF, and shorter lengths of ACR, SCR and CC. In conclusion, this study provides novel evidence of widespread microstructural alterations in OCD and suggests that OCD may involve abnormalities affecting a broader network of regions than commonly believed. |
2017-03-14 | |
语种 | 英语 |
DOI | 10.1038/tp.2017.22 |
发表期刊 | TRANSLATIONAL PSYCHIATRY |
ISSN | 2158-3188 |
卷号 | 7期号:0页码:e1062 |
期刊论文类型 | Article |
URL | 查看原文 |
收录类别 | SCI ; SSCI |
WOS关键词 | DIFFUSION-TENSOR ; FRACTIONAL ANISOTROPY ; SPATIAL STATISTICS ; IN-VIVO ; MICROSTRUCTURE ; ADOLESCENTS ; RELATIVES |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000397229000007 |
资助机构 | National Natural Science Foundation of China(81371487) ; National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2012BAI36B01) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/21322 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha 410011, Hunan, Peoples R China 2.Cent S Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China 3.South China Normal Univ, Sch Psychol, Ctr Studies Psychol Applicat, Guangzhou, Guangdong, Peoples R China 4.Cent S Univ, Xiangya Hosp 2, Dept Radiol, Changsha, Hunan, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Gan, J.,Zhong, M.,Fan, J.,et al. Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder[J]. TRANSLATIONAL PSYCHIATRY,2017,7(0):e1062. |
APA | Gan, J..,Zhong, M..,Fan, J..,Liu, W..,Niu, C..,...&Zhu, X..(2017).Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder.TRANSLATIONAL PSYCHIATRY,7(0),e1062. |
MLA | Gan, J.,et al."Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder".TRANSLATIONAL PSYCHIATRY 7.0(2017):e1062. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Abnormal white matte(2356KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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