PSYCH OpenIR  > 中国科学院心理健康重点实验室
Effects of nicotine on response inhibition and interference control
Ettinger, Ulrich1; Faiola, Eliana1; Kasparbauer, Anna-Maria1; Petrovsky, Nadine1; Chan, Raymond C. K.2,3; Liepelt, Roman4; Kumari, Veena5; Ulrich Ettinger
2017-04-01
发表期刊PSYCHOPHARMACOLOGY
通讯作者邮箱ulrich.ettinger@uni-bonn.de
ISSN0033-3158
文章类型Article
卷号234期号:7页码:1093-1111
摘要

Nicotine is a cholinergic agonist with known procognitive effects in the domains of alerting and orienting attention. However, its effects on attentional top-down functions such as response inhibition and interference control are less well characterised. Here, we investigated the effects of 7 mg transdermal nicotine on performance on a battery of response inhibition and interference control tasks. A sample of N = 44 healthy adult non-smokers performed antisaccade, stop signal, Stroop, go/no-go, flanker, shape matching and Simon tasks, as well as the attentional network test (ANT) and a continuous performance task (CPT). Nicotine was administered in a with-in-subjects, double-blind, placebo-controlled design, with order of drug administration counterbalanced. Relative to placebo, nicotine led to significantly shorter reaction times on a prosaccade task and on CPT hits but did not significantly improve inhibitory or interference control performance on any task. Instead, nicotine had a negative influence in increasing the interference effect on the Simon task. Nicotine did not alter inter-individual associations between reaction times on congruent trials and error rates on incongruent trials on any task. Finally, there were effects involving order of drug administration, suggesting practice effects but also beneficial nicotine effects when the compound was administered first. Overall, our findings support previous studies showing positive effects of nicotine on basic attentional functions but do not provide direct evidence for an improvement of top-down cognitive control through acute administration of nicotine at this dose in healthy non-smokers.

关键词Nicotine Acetylcholine Cognition Executive Function Inhibitory Control Attention
DOI10.1007/s00213-017-4542-8
收录类别SCI ; SSCI
语种英语
项目资助者Gielen- Leyendecker Fellowship ; Humboldt Foundation
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000398364200005
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; LATENT-VARIABLE ANALYSIS ; SACCADIC EYE-MOVEMENTS ; BEHAVIORAL-INHIBITION ; COGNITIVE ENHANCEMENT ; EXECUTIVE FUNCTIONS ; NEVER-SMOKERS ; ANTISACCADE PERFORMANCE ; INDIVIDUAL-DIFFERENCES ; SUBCUTANEOUS NICOTINE
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21329
专题中国科学院心理健康重点实验室
通讯作者Ulrich Ettinger
作者单位1.Univ Bonn, Dept Psychol, Kaiser Karl Ring 9, D-53111 Bonn, Germany
2.Inst Psychol, CAS Key Lab Mental Hlth, NACN Lab, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.German Sport Univ Cologne, Inst Psychol, Cologne, Germany
5.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London, England
推荐引用方式
GB/T 7714
Ettinger, Ulrich,Faiola, Eliana,Kasparbauer, Anna-Maria,et al. Effects of nicotine on response inhibition and interference control[J]. PSYCHOPHARMACOLOGY,2017,234(7):1093-1111.
APA Ettinger, Ulrich.,Faiola, Eliana.,Kasparbauer, Anna-Maria.,Petrovsky, Nadine.,Chan, Raymond C. K..,...&Ulrich Ettinger.(2017).Effects of nicotine on response inhibition and interference control.PSYCHOPHARMACOLOGY,234(7),1093-1111.
MLA Ettinger, Ulrich,et al."Effects of nicotine on response inhibition and interference control".PSYCHOPHARMACOLOGY 234.7(2017):1093-1111.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Effects of nicotine (764KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ettinger, Ulrich]的文章
[Faiola, Eliana]的文章
[Kasparbauer, Anna-Maria]的文章
百度学术
百度学术中相似的文章
[Ettinger, Ulrich]的文章
[Faiola, Eliana]的文章
[Kasparbauer, Anna-Maria]的文章
必应学术
必应学术中相似的文章
[Ettinger, Ulrich]的文章
[Faiola, Eliana]的文章
[Kasparbauer, Anna-Maria]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Effects of nicotine on response inhibition and interference control.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。