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Effects of nicotine on response inhibition and interference control
Ettinger, Ulrich1; Faiola, Eliana1; Kasparbauer, Anna-Maria1; Petrovsky, Nadine1; Chan, Raymond C. K.2,3; Liepelt, Roman4; Kumari, Veena5; Ulrich Ettinger
2017-04-01
Source PublicationPSYCHOPHARMACOLOGY
Correspondent Emailulrich.ettinger@uni-bonn.de
ISSN0033-3158
SubtypeArticle
Volume234Issue:7Pages:1093-1111
Abstract

Nicotine is a cholinergic agonist with known procognitive effects in the domains of alerting and orienting attention. However, its effects on attentional top-down functions such as response inhibition and interference control are less well characterised. Here, we investigated the effects of 7 mg transdermal nicotine on performance on a battery of response inhibition and interference control tasks. A sample of N = 44 healthy adult non-smokers performed antisaccade, stop signal, Stroop, go/no-go, flanker, shape matching and Simon tasks, as well as the attentional network test (ANT) and a continuous performance task (CPT). Nicotine was administered in a with-in-subjects, double-blind, placebo-controlled design, with order of drug administration counterbalanced. Relative to placebo, nicotine led to significantly shorter reaction times on a prosaccade task and on CPT hits but did not significantly improve inhibitory or interference control performance on any task. Instead, nicotine had a negative influence in increasing the interference effect on the Simon task. Nicotine did not alter inter-individual associations between reaction times on congruent trials and error rates on incongruent trials on any task. Finally, there were effects involving order of drug administration, suggesting practice effects but also beneficial nicotine effects when the compound was administered first. Overall, our findings support previous studies showing positive effects of nicotine on basic attentional functions but do not provide direct evidence for an improvement of top-down cognitive control through acute administration of nicotine at this dose in healthy non-smokers.

KeywordNicotine Acetylcholine Cognition Executive Function Inhibitory Control Attention
DOI10.1007/s00213-017-4542-8
Indexed BySCI ; SSCI
Language英语
Funding OrganizationGielen- Leyendecker Fellowship ; Humboldt Foundation
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectNeurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000398364200005
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; LATENT-VARIABLE ANALYSIS ; SACCADIC EYE-MOVEMENTS ; BEHAVIORAL-INHIBITION ; COGNITIVE ENHANCEMENT ; EXECUTIVE FUNCTIONS ; NEVER-SMOKERS ; ANTISACCADE PERFORMANCE ; INDIVIDUAL-DIFFERENCES ; SUBCUTANEOUS NICOTINE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21329
Collection中国科学院心理健康重点实验室
Corresponding AuthorUlrich Ettinger
Affiliation1.Univ Bonn, Dept Psychol, Kaiser Karl Ring 9, D-53111 Bonn, Germany
2.Inst Psychol, CAS Key Lab Mental Hlth, NACN Lab, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.German Sport Univ Cologne, Inst Psychol, Cologne, Germany
5.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London, England
Recommended Citation
GB/T 7714
Ettinger, Ulrich,Faiola, Eliana,Kasparbauer, Anna-Maria,et al. Effects of nicotine on response inhibition and interference control[J]. PSYCHOPHARMACOLOGY,2017,234(7):1093-1111.
APA Ettinger, Ulrich.,Faiola, Eliana.,Kasparbauer, Anna-Maria.,Petrovsky, Nadine.,Chan, Raymond C. K..,...&Ulrich Ettinger.(2017).Effects of nicotine on response inhibition and interference control.PSYCHOPHARMACOLOGY,234(7),1093-1111.
MLA Ettinger, Ulrich,et al."Effects of nicotine on response inhibition and interference control".PSYCHOPHARMACOLOGY 234.7(2017):1093-1111.
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