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Locomotor activity: A distinctive index in morphine self-administration in rats
Zhang, Jian-Jun1,2,3,4; Kong, Qingyao3,4
First AuthorZhang, Jian-Jun
Source PublicationPLOS ONE
Contribution Rank1

Self-administration of addictive drugs is a widely used tool for studying behavioral, neurobiological, and genetic factors in addiction. However, how locomotor activity is affected during self-administration of addictive drugs has not been extensively studied. In our present study, we tested the locomotor activity levels during acquisition, extinction and reinstatement of morphine self-administration in rats. We found that compared with saline self-administration (SA), rats that trained with morphine SA had higher locomotor activity. Rats that successfully acquired SA also showed higher locomotor activity than rats that failed in acquiring SA. Moreover, locomotor activity was correlated with the number of drug infusions but not with the number of inactive pokes. We also tested the locomotor activity in the extinction and the morphine-primed reinstatement session. Interestingly, we found that in the first extinction session, although the number of active pokes did not change, the locomotor activity was significantly lower than in the last acquisition session, and this decrease can be maintained for at least six days. Finally, morphine priming enhanced the locomotor activity during the reinstatement test, regardless of if the active pokes were significantly increased or not. Our results clearly suggest that locomotor activity, which may reflect the pharmacological effects of morphine, is different from drug seeking behavior and is a distinctive index in drug self administration.

Indexed BySCI
Funding OrganizationNational Natural Science Research Foundation of China (NSFC)(31400880)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000399353500038
WOS HeadingsScience & Technology
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Document Type期刊论文
Corresponding AuthorZhang, Jian-Jun
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peking Univ, Coll Life Sci, Lab Neurobiol, Beijing, Peoples R China
4.Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Jian-Jun,Kong, Qingyao. Locomotor activity: A distinctive index in morphine self-administration in rats[J]. PLOS ONE,2017,12(4):1-14.
APA Zhang, Jian-Jun,&Kong, Qingyao.(2017).Locomotor activity: A distinctive index in morphine self-administration in rats.PLOS ONE,12(4),1-14.
MLA Zhang, Jian-Jun,et al."Locomotor activity: A distinctive index in morphine self-administration in rats".PLOS ONE 12.4(2017):1-14.
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