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Locomotor activity: A distinctive index in morphine self-administration in rats
Zhang, Jian-Jun1,2,3,4; Kong, Qingyao3,4
第一作者Zhang, Jian-Jun
2017-04-05
发表期刊PLOS ONE
ISSN1932-6203
文章类型Article
卷号12期号:4页码:1-14
Q分类Q1
产权排序1
摘要

Self-administration of addictive drugs is a widely used tool for studying behavioral, neurobiological, and genetic factors in addiction. However, how locomotor activity is affected during self-administration of addictive drugs has not been extensively studied. In our present study, we tested the locomotor activity levels during acquisition, extinction and reinstatement of morphine self-administration in rats. We found that compared with saline self-administration (SA), rats that trained with morphine SA had higher locomotor activity. Rats that successfully acquired SA also showed higher locomotor activity than rats that failed in acquiring SA. Moreover, locomotor activity was correlated with the number of drug infusions but not with the number of inactive pokes. We also tested the locomotor activity in the extinction and the morphine-primed reinstatement session. Interestingly, we found that in the first extinction session, although the number of active pokes did not change, the locomotor activity was significantly lower than in the last acquisition session, and this decrease can be maintained for at least six days. Finally, morphine priming enhanced the locomotor activity during the reinstatement test, regardless of if the active pokes were significantly increased or not. Our results clearly suggest that locomotor activity, which may reflect the pharmacological effects of morphine, is different from drug seeking behavior and is a distinctive index in drug self administration.

DOI10.1371/journal.pone.0174272
收录类别SCI
语种英语
项目资助者National Natural Science Research Foundation of China (NSFC)(31400880)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000399353500038
WOS标题词Science & Technology
关键词[WOS]BEHAVIORAL SENSITIZATION ; SEEKING BEHAVIOR ; HEROIN-SEEKING ; KAPPA-AGONIST ; REINSTATEMENT ; COCAINE ; ADDICTION ; RECEPTORS ; RELAPSE
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21400
专题中国科学院心理健康重点实验室
通讯作者Zhang, Jian-Jun
作者单位1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peking Univ, Coll Life Sci, Lab Neurobiol, Beijing, Peoples R China
4.Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jian-Jun,Kong, Qingyao. Locomotor activity: A distinctive index in morphine self-administration in rats[J]. PLOS ONE,2017,12(4):1-14.
APA Zhang, Jian-Jun,&Kong, Qingyao.(2017).Locomotor activity: A distinctive index in morphine self-administration in rats.PLOS ONE,12(4),1-14.
MLA Zhang, Jian-Jun,et al."Locomotor activity: A distinctive index in morphine self-administration in rats".PLOS ONE 12.4(2017):1-14.
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