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Locomotor activity: A distinctive index in morphine self-administration in rats | |
Zhang, Jian-Jun1,2,3,4; Kong, Qingyao3,4 | |
第一作者 | Zhang, Jian-Jun |
心理所单位排序 | 1 |
摘要 | Self-administration of addictive drugs is a widely used tool for studying behavioral, neurobiological, and genetic factors in addiction. However, how locomotor activity is affected during self-administration of addictive drugs has not been extensively studied. In our present study, we tested the locomotor activity levels during acquisition, extinction and reinstatement of morphine self-administration in rats. We found that compared with saline self-administration (SA), rats that trained with morphine SA had higher locomotor activity. Rats that successfully acquired SA also showed higher locomotor activity than rats that failed in acquiring SA. Moreover, locomotor activity was correlated with the number of drug infusions but not with the number of inactive pokes. We also tested the locomotor activity in the extinction and the morphine-primed reinstatement session. Interestingly, we found that in the first extinction session, although the number of active pokes did not change, the locomotor activity was significantly lower than in the last acquisition session, and this decrease can be maintained for at least six days. Finally, morphine priming enhanced the locomotor activity during the reinstatement test, regardless of if the active pokes were significantly increased or not. Our results clearly suggest that locomotor activity, which may reflect the pharmacological effects of morphine, is different from drug seeking behavior and is a distinctive index in drug self administration. |
2017-04-05 | |
语种 | 英语 |
DOI | 10.1371/journal.pone.0174272 |
发表期刊 | PLOS ONE |
ISSN | 1932-6203 |
卷号 | 12期号:4页码:1-14 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | BEHAVIORAL SENSITIZATION ; SEEKING BEHAVIOR ; HEROIN-SEEKING ; KAPPA-AGONIST ; REINSTATEMENT ; COCAINE ; ADDICTION ; RECEPTORS ; RELAPSE |
WOS标题词 | Science & Technology |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000399353500038 |
Q分类 | Q1 |
资助机构 | National Natural Science Research Foundation of China (NSFC)(31400880) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/21400 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Jian-Jun |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Peking Univ, Coll Life Sci, Lab Neurobiol, Beijing, Peoples R China 4.Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Zhang, Jian-Jun,Kong, Qingyao. Locomotor activity: A distinctive index in morphine self-administration in rats[J]. PLOS ONE,2017,12(4):1-14. |
APA | Zhang, Jian-Jun,&Kong, Qingyao.(2017).Locomotor activity: A distinctive index in morphine self-administration in rats.PLOS ONE,12(4),1-14. |
MLA | Zhang, Jian-Jun,et al."Locomotor activity: A distinctive index in morphine self-administration in rats".PLOS ONE 12.4(2017):1-14. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Locomotor activity (3479KB) | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 |
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