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题名:
Locomotor activity: A distinctive index in morphine self-administration in rats
作者: Zhang Jianjun(张建军)1,2,3,4; Kong, Qingyao3,4
文章类型: Article
刊名: PLOS ONE
ISSN号: 1932-6203
出版日期: 2017-04-05
卷号: 12, 期号:4, 页码:1-14
收录类别: SCI
项目资助者: National Natural Science Research Foundation of China (NSFC)(31400880)
英文摘要:

Self-administration of addictive drugs is a widely used tool for studying behavioral, neurobiological, and genetic factors in addiction. However, how locomotor activity is affected during self-administration of addictive drugs has not been extensively studied. In our present study, we tested the locomotor activity levels during acquisition, extinction and reinstatement of morphine self-administration in rats. We found that compared with saline self-administration (SA), rats that trained with morphine SA had higher locomotor activity. Rats that successfully acquired SA also showed higher locomotor activity than rats that failed in acquiring SA. Moreover, locomotor activity was correlated with the number of drug infusions but not with the number of inactive pokes. We also tested the locomotor activity in the extinction and the morphine-primed reinstatement session. Interestingly, we found that in the first extinction session, although the number of active pokes did not change, the locomotor activity was significantly lower than in the last acquisition session, and this decrease can be maintained for at least six days. Finally, morphine priming enhanced the locomotor activity during the reinstatement test, regardless of if the active pokes were significantly increased or not. Our results clearly suggest that locomotor activity, which may reflect the pharmacological effects of morphine, is different from drug seeking behavior and is a distinctive index in drug self administration.

语种: 英语
WOS记录号: WOS:000399353500038
DOI标识: 10.1371/journal.pone.0174272
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: BEHAVIORAL SENSITIZATION ; SEEKING BEHAVIOR ; HEROIN-SEEKING ; KAPPA-AGONIST ; REINSTATEMENT ; COCAINE ; ADDICTION ; RECEPTORS ; RELAPSE
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.psych.ac.cn/handle/311026/21400
Appears in Collections:中国科学院心理健康重点实验室_期刊论文

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作者单位: 1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peking Univ, Coll Life Sci, Lab Neurobiol, Beijing, Peoples R China
4.Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China

Recommended Citation:
Zhang, Jian-Jun,Kong, Qingyao. Locomotor activity: A distinctive index in morphine self-administration in rats[J]. PLOS ONE,2017,12(4):1-14.
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