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皮质酮对吗啡条件性位置偏爱及条件性精神运动获得的影响
Alternative TitleEFFECTS OF CORTICOSTERONE ON MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE AND CONDITIONED LOCOMOTION ACTIVITY
李勇辉; 郑希耕; 罗小景; 杨晓燕; 隋南;  隋 南
Abstract目的 :研究皮质酮作用下吗啡条件性位置偏爱 (CPP)及条件性精神运动的变化趋势及其可能机制 ,为探讨应激、环境线索诱发复吸的机制提供基础。方法 :32只♂SD大鼠分成 4组。训练 2d ,1次药物匹配训练 (吗啡 2mg·kg- 1 ,皮质酮 5mg·kg- 1 ,ip ,提前 2 0min注射 ) ,1次生理盐水训练。观察训练前后大鼠在伴药侧停留的时间 ,急性给药后的运动及条件性精神运动的变化。结果 :(1)吗啡组训练后在伴药侧停留的时间显著长于对照组 (P <0 0 1) ,皮质酮吗啡组、皮质酮组与对照组比较差异无显著性 (P >0 0 5 ) ; (2 )在 5 0、6 0min时皮质酮吗啡组的急性精神运动显著大于吗啡组和对照组 (P <0 0 1) ; (3)皮质酮吗啡组大鼠的条件性精神运动显著大于对照组、吗啡组 (P <0 0 1,P <0 0 5 )。结论 :5mg·kg- 1 的皮质酮显著抑制吗啡CPP的获得 ,但促进吗啡条件性精神运动的获得以及急性精神运动。CPP与条件性精神运动获得的机制可能存在差异
Keyword皮质酮 吗啡 条件性位置偏爱 条件性精神运动
2004
Language中文
Source Publication中国药物依赖性杂志
ISSN1007-9718
Volume13Issue:3Pages:183-186
Indexed ByASPT来源刊 CJFD收录刊
Funding Project国家重点基础研究发展计划 (973计划,2 0 0 3CB5 15 4 0 4 );; 国家自然科学基金重点项目(30 2 30 130 ,30 170 32 4 );; 中科院知识创新工程项目 (KSCX2 -SW - 2 0 4 - 0 2 )资助
NoteTo investigate the effect of corticosterone on morphine - induced CPP and conditioned locomotion activity in order to provide the foundation for exploring the mechanismof stress - and cue - induced relapse. Methods : 32 male SD rats were divided into 4 groups , and trained once a day for two days withdrug (morphine , corticosterone) and saline in an alternate sequence. Corticosterone (5 mg·kg- 1 , ip) was administrated 20 minutes prior to morphine (2 mg·kg- 1 ip) training. Time spent on drug - paired compartment was recorded , and locomotor activity was recorded immediately after morphine administration and saline challenge.Results : (1) Compared with control group , rats treated with morphine spent more time in drug - paired compartment after training ( P < 0.01) ; no difference between control group and corticosteronePmorphine - treated rats( P > 0.05) ; (2) In the last twenty minutes , corticosterone increased the acute psychomotor activity of morphine -treated rats ( P < 0.05) ; (3) Corticosterone increased the conditioned psychomotor activity of morphine - treatedrats ( P < 0.01) . Conclusion : Corticosterone (5 mg·kg- 1 ip) inhibited the acquisition of morphine - induced CPP , but facilitated the acquisition of morphine - induced conditioned locomotor activity and acute psychomotor activity. The mechanism of CPP may be different from that of conditioned locomotor activity.
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/2142
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding Author 隋 南
Recommended Citation
GB/T 7714
李勇辉,郑希耕,罗小景,等. 皮质酮对吗啡条件性位置偏爱及条件性精神运动获得的影响[J]. 中国药物依赖性杂志,2004,13(3):183-186.
APA 李勇辉,郑希耕,罗小景,杨晓燕,隋南,& 隋 南.(2004).皮质酮对吗啡条件性位置偏爱及条件性精神运动获得的影响.中国药物依赖性杂志,13(3),183-186.
MLA 李勇辉,et al."皮质酮对吗啡条件性位置偏爱及条件性精神运动获得的影响".中国药物依赖性杂志 13.3(2004):183-186.
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