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Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson's disease: a resting-state fMRI study
Hu, Xiaopeng1; Chen, Siyi2,3; Huang, Chang-Bing2; Qian, Yinfeng1; Yu, Yongqiang1
2017-06-01
Source PublicationMETABOLIC BRAIN DISEASE
ISSN0885-7490
SubtypeArticle
Volume32Issue:3Pages:685-692
Abstract

To investigate the frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) in patients with Wilson's disease (WD). Resting-state function magnetic resonance imaging (R-fMRI) were employed to measure the amplitude of ALFF in 28 patients with WD and 27 matched normal controls. Slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.073 Hz) frequency bands were analyzed. Apart from the observation of atrophy in the cerebellum, basal ganglia, occipital gyrus, frontal gyrus, precentral gyrus, and paracentral lobule, we also found widespread differences in ALFF of the two bands in the medial frontal gyrus, inferior temporal gyrus, insula, basal ganglia, hippocampus/parahippocampal gyrus, and thalamus bilaterally. Compared to normal controls, WD patients had increased ALFF in the posterior lobe of the cerebellum, inferior temporal gyrus, brain stem, basal ganglia, and decreased ALFF in the anterior lobe of the cerebellum and medial frontal gyrus. Specifically, we observed that the ALFF abnormalities in the cerebellum and middle frontal gyrus were greater in the slow-5 than in the slow-4 band. Correlation analysis showed consistently positive correlations between urinary copper excretion (Cu), serum ceruloplasmin (CP) and ALFFs in the cerebellum. Our study suggests the accumulation of copper profoundly impaired intrinsic brain activity and the impairments seem to be frequency-dependent. These results provide further insights into the understanding of the pathophysiology of WD.

KeywordWilson's disease Resting-state functional magnetic resonance imaging Amplitude of low-frequency fluctuations
DOI10.1007/s11011-016-9946-3
Indexed BySCI
Language英语
Funding OrganizationResearch Project of Anhui Province(1301042202) ; Knowledge Innovation Program of the Chinese Academy of Sciences(Y3CX102003) ; Institute of Psychology, CAS(Y1CX201006)
WOS Research AreaEndocrinology & Metabolism ; Neurosciences & Neurology
WOS SubjectEndocrinology & Metabolism ; Neurosciences
WOS IDWOS:000400767700005
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordPOSITRON-EMISSION-TOMOGRAPHY ; BASAL GANGLIA ; CLINICAL CORRELATION ; ALZHEIMERS-DISEASE ; FUNCTIONAL MRI ; BRAIN MRI ; DISORDERS ; EFFICACY ; CORTEX
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21484
Collection中国科学院行为科学重点实验室
Affiliation1.Anhui Med Univ, Dept Radiol, Affiliated Hosp 1, Hefei 230022, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
3.Ludwig Maximilians Univ Munchen, Dept Psychol, D-80802 Munich, Germany
Recommended Citation
GB/T 7714
Hu, Xiaopeng,Chen, Siyi,Huang, Chang-Bing,et al. Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson's disease: a resting-state fMRI study[J]. METABOLIC BRAIN DISEASE,2017,32(3):685-692.
APA Hu, Xiaopeng,Chen, Siyi,Huang, Chang-Bing,Qian, Yinfeng,&Yu, Yongqiang.(2017).Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson's disease: a resting-state fMRI study.METABOLIC BRAIN DISEASE,32(3),685-692.
MLA Hu, Xiaopeng,et al."Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson's disease: a resting-state fMRI study".METABOLIC BRAIN DISEASE 32.3(2017):685-692.
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