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White matter microstructural abnormalities and their association with anticipatory anhedonia in depression
Yang, Xin-hua1,2; Wang, Yi1,3; Wang, Dong-fang2; Tian, Kai2; Cheung, Eric F. C.4; Xie, Guang-rong5; Chan, Raymond C. K.1,3
2017-06-30
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
SubtypeArticle
Volume264Issue:0Pages:29-34
Abstract

Anhedonia is associated with dysfunction of the neural circuitry of reward in patients with major depressive disorder (MDD). However, its neurobiological basis is not fully understood. The present study examined the association between anhedonia and white matter (WM) characteristics in patients with first-episode MDD. We recruited 30 patients with first-episode drug-naive MDD and 28 healthy controls (HC) to undergo diffusion weighted imaging. We examined specifically the correlation between WM characteristics and anhedonia measured with the Temporal Experience of Pleasure Scale (TEPS) in MDD patients. Using Track-Based Spatial Statistics (TBSS), we found that MDD patients exhibited reduced fractional anisotropy (FA) in the left cingulum and the forceps minor. These patients also exhibited increased radial diffusivity (RD) in several major tracts including the bilateral anterior thalamic radiation, the corticospinal tract, the superior longitudinal fasciculus and the uncinate fasciculus in the left hemisphere. Correlational analysis showed that increased RD was significantly correlated with anticipatory anhedonia in the MDD group, while reduced mean FA was correlated with consummatory anhedonia in HC. These preliminary findings suggest that left-sided WM tracts abnormalities may contribute to the development of anhedonia in MDD patients.

KeywordAnhedonia Major depressive disorder White matter Cingulum Forceps minor
DOI10.1016/j.pscychresns.2017.04.005
Indexed BySCI ; SSCI
Language英语
Funding OrganizationChinese Academy of Sciences(XDB02030002) ; Beijing Municipal Science and Technology Commission Grant(Z161100000216138) ; Beijing Training Project for the Leading Talents in Science and Technology(Z151100000315020) ; National Science Fund China(81571317) ; CAS Key Laboratory of Mental Health ; CAS/SAFEA International Partnership Programme for Creative Research Teams(Y2CX131003) ; China Postdoctoral Science Foundation(2015M571149) ; Natural Science Foundation of Hunan Province(2016JJ3068) ; Social Science Foundation of Hunan Province(16YBA200) ; Youth Project of Hunan Provincial Education Department(16B132) ; 1515 talents Programme of Hunan Agricultural University
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000402460000005
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordMEDIAL FOREBRAIN-BUNDLE ; HAMILTON-PLEASURE SCALE ; HEDONIC TONE ; DIFFUSION ; DISORDER ; BRAIN ; MRI
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21532
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Hunan Agr Univ, Key Res Inst Philosophies & Social Sci Hunan Prov, Inst Educ, Rural Children & Adolescents Res Ctr Hlth Promot, Changsha, Hunan, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
5.Cent S Univ, Key Lab Psychiat & Mental Hlth Hunan Prov, Xiangya Hosp 2, Mental Hlth Inst,Natl Technol Inst Psychiat, Changsha, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Yang, Xin-hua,Wang, Yi,Wang, Dong-fang,et al. White matter microstructural abnormalities and their association with anticipatory anhedonia in depression[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2017,264(0):29-34.
APA Yang, Xin-hua.,Wang, Yi.,Wang, Dong-fang.,Tian, Kai.,Cheung, Eric F. C..,...&Chan, Raymond C. K..(2017).White matter microstructural abnormalities and their association with anticipatory anhedonia in depression.PSYCHIATRY RESEARCH-NEUROIMAGING,264(0),29-34.
MLA Yang, Xin-hua,et al."White matter microstructural abnormalities and their association with anticipatory anhedonia in depression".PSYCHIATRY RESEARCH-NEUROIMAGING 264.0(2017):29-34.
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