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The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis
Gao, Qian1,2; Zhang, Junfeng3; Wang, Xiumei4; Liu, Ying4; He, Rongqiao4,5; Liu, Xingfeng3; Wang, Fei1; Feng, Jing1; Yang, Dongling1; Wang, Zhaoqing1; Meng, Anming3; Yan, Xiyun1,2
2017-06-07
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
SubtypeArticle
Volume8Issue:0Pages:1-13
Abstract

The apical-basal (AB) polarity and planar cell polarity (PCP) provide an animal cell population with different phenotypes during morphogenesis. However, how cells couple these two patterning systems remains unclear. Here we provide in vivo evidence that melanoma cell adhesion molecule (MCAM) coordinates AB polarity-driven lumenogenesis and c-Jun N-terminal kinase (JNK)/PCP-dependent ciliogenesis. We identify that MCAM is an independent receptor of fibroblast growth factor 4 (FGF4), a membrane anchor of phospholipase C-gamma (PLC-gamma), an immediate upstream receptor of nuclear factor of activated T-cells (NFAT) and a constitutive activator of JNK. We find that MCAM-mediated vesicular trafficking towards FGF4, while generating a priority-grade transcriptional response of NFAT determines lumenogenesis. We demonstrate that MCAM plays indispensable roles in ciliogenesis through activating JNK independently of FGF signals. Furthermore, mcam-deficient zebrafish and Xenopus exhibit a global defect in left-right (LR) asymmetric establishment as a result of morphogenetic failure of their LR organizers. Therefore, MCAM coordination of AB polarity and PCP provides insight into the general mechanisms of morphogenesis.

DOI10.1038/ncomms15279
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81371330 ; National Basic Research Program of China(2015CB553705) ; 'Strategic Priority Research Program' of the Chinese Academy of Sciences(XDA12020207) ; 91529306 ; 81272409)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000402802700001
WOS HeadingsScience & Technology
WOS KeywordLEFT-RIGHT ASYMMETRY ; EPITHELIAL-CELLS ; ZEBRAFISH ; CD146 ; ADHESION ; ANGIOGENESIS ; ACTIVATION ; MECHANISMS ; REGULATOR ; EXTENSION
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21536
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Tsinghua Univ, Tsinghua Peking Ctr Life Sci, State Key Lab Biomembrane & Membrane Engn, Beijing 100084, Peoples R China
4.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Gao, Qian,Zhang, Junfeng,Wang, Xiumei,et al. The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis[J]. NATURE COMMUNICATIONS,2017,8(0):1-13.
APA Gao, Qian.,Zhang, Junfeng.,Wang, Xiumei.,Liu, Ying.,He, Rongqiao.,...&Yan, Xiyun.(2017).The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis.NATURE COMMUNICATIONS,8(0),1-13.
MLA Gao, Qian,et al."The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis".NATURE COMMUNICATIONS 8.0(2017):1-13.
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