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The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis
Gao, Qian1,2; Zhang, Junfeng3; Wang, Xiumei4; Liu, Ying4; He, Rongqiao4,5; Liu, Xingfeng3; Wang, Fei1; Feng, Jing1; Yang, Dongling1; Wang, Zhaoqing1; Meng, Anming3; Yan, Xiyun1,2
2017-06-07
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
文章类型Article
卷号8期号:0页码:1-13
摘要

The apical-basal (AB) polarity and planar cell polarity (PCP) provide an animal cell population with different phenotypes during morphogenesis. However, how cells couple these two patterning systems remains unclear. Here we provide in vivo evidence that melanoma cell adhesion molecule (MCAM) coordinates AB polarity-driven lumenogenesis and c-Jun N-terminal kinase (JNK)/PCP-dependent ciliogenesis. We identify that MCAM is an independent receptor of fibroblast growth factor 4 (FGF4), a membrane anchor of phospholipase C-gamma (PLC-gamma), an immediate upstream receptor of nuclear factor of activated T-cells (NFAT) and a constitutive activator of JNK. We find that MCAM-mediated vesicular trafficking towards FGF4, while generating a priority-grade transcriptional response of NFAT determines lumenogenesis. We demonstrate that MCAM plays indispensable roles in ciliogenesis through activating JNK independently of FGF signals. Furthermore, mcam-deficient zebrafish and Xenopus exhibit a global defect in left-right (LR) asymmetric establishment as a result of morphogenetic failure of their LR organizers. Therefore, MCAM coordination of AB polarity and PCP provides insight into the general mechanisms of morphogenesis.

DOI10.1038/ncomms15279
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81371330 ; National Basic Research Program of China(2015CB553705) ; 'Strategic Priority Research Program' of the Chinese Academy of Sciences(XDA12020207) ; 91529306 ; 81272409)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000402802700001
WOS标题词Science & Technology
关键词[WOS]LEFT-RIGHT ASYMMETRY ; EPITHELIAL-CELLS ; ZEBRAFISH ; CD146 ; ADHESION ; ANGIOGENESIS ; ACTIVATION ; MECHANISMS ; REGULATOR ; EXTENSION
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21536
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Tsinghua Univ, Tsinghua Peking Ctr Life Sci, State Key Lab Biomembrane & Membrane Engn, Beijing 100084, Peoples R China
4.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Gao, Qian,Zhang, Junfeng,Wang, Xiumei,et al. The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis[J]. NATURE COMMUNICATIONS,2017,8(0):1-13.
APA Gao, Qian.,Zhang, Junfeng.,Wang, Xiumei.,Liu, Ying.,He, Rongqiao.,...&Yan, Xiyun.(2017).The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis.NATURE COMMUNICATIONS,8(0),1-13.
MLA Gao, Qian,et al."The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis".NATURE COMMUNICATIONS 8.0(2017):1-13.
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