Institutional Repository of Key Laboratory of Mental Health, CAS
The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis | |
Gao, Qian1,2; Zhang, Junfeng3; Wang, Xiumei4; Liu, Ying4; He, Rongqiao4,5; Liu, Xingfeng3; Wang, Fei1; Feng, Jing1; Yang, Dongling1; Wang, Zhaoqing1; Meng, Anming3; Yan, Xiyun1,2 | |
摘要 | The apical-basal (AB) polarity and planar cell polarity (PCP) provide an animal cell population with different phenotypes during morphogenesis. However, how cells couple these two patterning systems remains unclear. Here we provide in vivo evidence that melanoma cell adhesion molecule (MCAM) coordinates AB polarity-driven lumenogenesis and c-Jun N-terminal kinase (JNK)/PCP-dependent ciliogenesis. We identify that MCAM is an independent receptor of fibroblast growth factor 4 (FGF4), a membrane anchor of phospholipase C-gamma (PLC-gamma), an immediate upstream receptor of nuclear factor of activated T-cells (NFAT) and a constitutive activator of JNK. We find that MCAM-mediated vesicular trafficking towards FGF4, while generating a priority-grade transcriptional response of NFAT determines lumenogenesis. We demonstrate that MCAM plays indispensable roles in ciliogenesis through activating JNK independently of FGF signals. Furthermore, mcam-deficient zebrafish and Xenopus exhibit a global defect in left-right (LR) asymmetric establishment as a result of morphogenetic failure of their LR organizers. Therefore, MCAM coordination of AB polarity and PCP provides insight into the general mechanisms of morphogenesis. |
2017-06-07 | |
语种 | 英语 |
DOI | 10.1038/ncomms15279 |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
卷号 | 8期号:0页码:1-13 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | LEFT-RIGHT ASYMMETRY ; EPITHELIAL-CELLS ; ZEBRAFISH ; CD146 ; ADHESION ; ANGIOGENESIS ; ACTIVATION ; MECHANISMS ; REGULATOR ; EXTENSION |
WOS标题词 | Science & Technology |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000402802700001 |
资助机构 | National Natural Science Foundation of China(81371330 ; National Basic Research Program of China(2015CB553705) ; 'Strategic Priority Research Program' of the Chinese Academy of Sciences(XDA12020207) ; 91529306 ; 81272409) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/21536 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Tsinghua Univ, Tsinghua Peking Ctr Life Sci, State Key Lab Biomembrane & Membrane Engn, Beijing 100084, Peoples R China 4.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Gao, Qian,Zhang, Junfeng,Wang, Xiumei,et al. The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis[J]. NATURE COMMUNICATIONS,2017,8(0):1-13. |
APA | Gao, Qian.,Zhang, Junfeng.,Wang, Xiumei.,Liu, Ying.,He, Rongqiao.,...&Yan, Xiyun.(2017).The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis.NATURE COMMUNICATIONS,8(0),1-13. |
MLA | Gao, Qian,et al."The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis".NATURE COMMUNICATIONS 8.0(2017):1-13. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
The signalling recep(2772KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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