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Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia
Nielsen, Jesper Duemose1,2; Madsen, Kristoffer H.3,4; Wang, Zheng3,5; Liu, Zhening5; Friston, Karl J.6; Zhou, Yuan1,6,7
2017-07-01
发表期刊CEREBRAL CORTEX
ISSN1047-3211
文章类型Article
卷号27期号:7页码:3832-3841
摘要

Working memory (WM) impairment is regarded as a core aspect of schizophrenia. However, the neural mechanisms behind this cognitive deficit remain unclear. The connectivity of a frontoparietal network is known to be important for subserving WM. Using functional magnetic resonance imaging, the current study investigated whether WM-dependent modulation of effective connectivity in this network is affected in a group of first-episode schizophrenia (FES) patients compared with similarly performing healthy participants during a verbal n-back task. Dynamic causal modeling (DCM) of the coupling between regions (left inferior frontal gyrus (IFG), left inferior parietal lobe (IPL), and primary visual area) identified in a psychophysiological interaction (PPI) analysis was performed to characterize effective connectivity during the n-back task. The PPI analysis revealed that the connectivity between the left IFG and left IPL was modulated by WM and that this modulation was reduced in FES patients. The subsequent DCM analysis confirmed this modulation by WM and found evidence that FES patients had reduced forward connectivity from IPL to IFG. These findings provide evidence for impaired WM modulation of frontoparietal effective connectivity in the early phase of schizophrenia, even with intact WM performance, suggesting a failure of context-sensitive coupling in the schizophrenic brain.

关键词dynamic causal modeling dysconnection hypothesis functional magnetic resonance imaging n-back
DOI10.1093/cercor/bhx050
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81371476 ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2012075) ; China Scholarship Council ; National Basic Research Program of China(2011CB707800) ; 91132301 ; 91432302)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000404404600027
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]FMRI TIME-SERIES ; FUNCTIONAL CONNECTIVITY ; PREFRONTAL CORTEX ; BRAIN ; METAANALYSIS ; ATTENTION ; TASK ; MAINTENANCE ; DYSFUNCTION ; PARIETAL
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21597
专题中国科学院行为科学重点实验室
作者单位1.Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Sinodanish Ctr Educ & Res, Aarhus, Denmark
3.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark
4.Copenhagen Univ Hosp Hvidovre, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, Hvidovre, Denmark
5.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China
6.UCL, Wellcome Trust Ctr Neuroimaging, London, England
7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Nielsen, Jesper Duemose,Madsen, Kristoffer H.,Wang, Zheng,et al. Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia[J]. CEREBRAL CORTEX,2017,27(7):3832-3841.
APA Nielsen, Jesper Duemose,Madsen, Kristoffer H.,Wang, Zheng,Liu, Zhening,Friston, Karl J.,&Zhou, Yuan.(2017).Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia.CEREBRAL CORTEX,27(7),3832-3841.
MLA Nielsen, Jesper Duemose,et al."Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia".CEREBRAL CORTEX 27.7(2017):3832-3841.
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