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题名:
Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia
作者: Nielsen, Jesper Duemose1,2; Madsen, Kristoffer H.3,4; Wang, Zheng3,5; Liu, Zhening5; Friston, Karl J.6; Yuan Zhou(周媛)1,6,7
文章类型: Article
关键词: dynamic causal modeling ; dysconnection hypothesis ; functional magnetic resonance imaging ; n-back
刊名: CEREBRAL CORTEX
ISSN号: 1047-3211
出版日期: 2017-07-01
卷号: 27, 期号:7, 页码:3832-3841
收录类别: SCI
项目资助者: National Natural Science Foundation of China(81371476 ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2012075) ; China Scholarship Council ; National Basic Research Program of China(2011CB707800) ; 91132301 ; 91432302)
英文摘要: Working memory (WM) impairment is regarded as a core aspect of schizophrenia. However, the neural mechanisms behind this cognitive deficit remain unclear. The connectivity of a frontoparietal network is known to be important for subserving WM. Using functional magnetic resonance imaging, the current study investigated whether WM-dependent modulation of effective connectivity in this network is affected in a group of first-episode schizophrenia (FES) patients compared with similarly performing healthy participants during a verbal n-back task. Dynamic causal modeling (DCM) of the coupling between regions (left inferior frontal gyrus (IFG), left inferior parietal lobe (IPL), and primary visual area) identified in a psychophysiological interaction (PPI) analysis was performed to characterize effective connectivity during the n-back task. The PPI analysis revealed that the connectivity between the left IFG and left IPL was modulated by WM and that this modulation was reduced in FES patients. The subsequent DCM analysis confirmed this modulation by WM and found evidence that FES patients had reduced forward connectivity from IPL to IFG. These findings provide evidence for impaired WM modulation of frontoparietal effective connectivity in the early phase of schizophrenia, even with intact WM performance, suggesting a failure of context-sensitive coupling in the schizophrenic brain.
语种: 英语
WOS记录号: WOS:000404404600027
DOI标识: 10.1093/cercor/bhx050
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: FMRI TIME-SERIES ; FUNCTIONAL CONNECTIVITY ; PREFRONTAL CORTEX ; BRAIN ; METAANALYSIS ; ATTENTION ; TASK ; MAINTENANCE ; DYSFUNCTION ; PARIETAL
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内容类型: 期刊论文
URI标识: http://ir.psych.ac.cn/handle/311026/21597
Appears in Collections:中国科学院行为科学重点实验室_期刊论文

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作者单位: 1.Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Sinodanish Ctr Educ & Res, Aarhus, Denmark
3.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark
4.Copenhagen Univ Hosp Hvidovre, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, Hvidovre, Denmark
5.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China
6.UCL, Wellcome Trust Ctr Neuroimaging, London, England
7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China

Recommended Citation:
Nielsen, Jesper Duemose,Madsen, Kristoffer H.,Wang, Zheng,et al. Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia[J]. CEREBRAL CORTEX,2017,27(7):3832-3841.
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