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Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia | |
Nielsen, Jesper Duemose1,2; Madsen, Kristoffer H.3,4; Wang, Zheng3,5; Liu, Zhening5; Friston, Karl J.6; Zhou, Yuan1,6,7![]() | |
Abstract | Working memory (WM) impairment is regarded as a core aspect of schizophrenia. However, the neural mechanisms behind this cognitive deficit remain unclear. The connectivity of a frontoparietal network is known to be important for subserving WM. Using functional magnetic resonance imaging, the current study investigated whether WM-dependent modulation of effective connectivity in this network is affected in a group of first-episode schizophrenia (FES) patients compared with similarly performing healthy participants during a verbal n-back task. Dynamic causal modeling (DCM) of the coupling between regions (left inferior frontal gyrus (IFG), left inferior parietal lobe (IPL), and primary visual area) identified in a psychophysiological interaction (PPI) analysis was performed to characterize effective connectivity during the n-back task. The PPI analysis revealed that the connectivity between the left IFG and left IPL was modulated by WM and that this modulation was reduced in FES patients. The subsequent DCM analysis confirmed this modulation by WM and found evidence that FES patients had reduced forward connectivity from IPL to IFG. These findings provide evidence for impaired WM modulation of frontoparietal effective connectivity in the early phase of schizophrenia, even with intact WM performance, suggesting a failure of context-sensitive coupling in the schizophrenic brain. |
Keyword | dynamic causal modeling dysconnection hypothesis functional magnetic resonance imaging n-back |
2017-07-01 | |
Language | 英语 |
DOI | 10.1093/cercor/bhx050 |
Source Publication | CEREBRAL CORTEX
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ISSN | 1047-3211 |
Volume | 27Issue:7Pages:3832-3841 |
Subtype | Article |
Indexed By | SCI |
WOS Keyword | FMRI TIME-SERIES ; FUNCTIONAL CONNECTIVITY ; PREFRONTAL CORTEX ; BRAIN ; METAANALYSIS ; ATTENTION ; TASK ; MAINTENANCE ; DYSFUNCTION ; PARIETAL |
WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
WOS Research Area | Neurosciences & Neurology |
WOS Subject | Neurosciences |
WOS ID | WOS:000404404600027 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.psych.ac.cn/handle/311026/21597 |
Collection | 中国科学院行为科学重点实验室 |
Affiliation | 1.Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Sinodanish Ctr Educ & Res, Aarhus, Denmark 3.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark 4.Copenhagen Univ Hosp Hvidovre, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, Hvidovre, Denmark 5.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China 6.UCL, Wellcome Trust Ctr Neuroimaging, London, England 7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
First Author Affilication | Key Laboratory of Behavioral Science, CAS |
Recommended Citation GB/T 7714 | Nielsen, Jesper Duemose,Madsen, Kristoffer H.,Wang, Zheng,et al. Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia[J]. CEREBRAL CORTEX,2017,27(7):3832-3841. |
APA | Nielsen, Jesper Duemose,Madsen, Kristoffer H.,Wang, Zheng,Liu, Zhening,Friston, Karl J.,&Zhou, Yuan.(2017).Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia.CEREBRAL CORTEX,27(7),3832-3841. |
MLA | Nielsen, Jesper Duemose,et al."Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia".CEREBRAL CORTEX 27.7(2017):3832-3841. |
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Working Memory Modul(513KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | Application Full Text |
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