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Local-to-remote cortical connectivity in amnestic mild cognitive impairment
Zhang, Yi-Wen1,2; Zhao, Zhi-Lian3,4; Qi, Zhigang3,4; Hu, Yang1,2; Wang, Yin-Shan1,2; Sheng, Can5; Sun, Yu5; Wang, Xiaoni5; Jiang, Li-Li1,2,6; Yan, Chao-Gan1,2,7; Li, Kuncheng3,4; Li, Hui-Jie1,2,6; Zuo, Xi-Nian1,2,6,7
First AuthorZhang, Yi-Wen, Zhao, Zhi-Lian
2017-08-01
Source PublicationNEUROBIOLOGY OF AGING
ISSN0197-4580
SubtypeArticle
Volume56Issue:0Pages:138-149
QuartileQ1
Contribution Rank1
Abstract

Alterations in both local and remote connectivity were reported in amnestic mild cognitive impairment aMCI) patients but rarely in the same group of patients. In the present study, we employed a novel resting-state functional magnetic resonance imaging (rfMRI) connectome index, regional functional homogeneity on the 2-dimensional cortical surface, to detect full-cortex vertex-wise changes of the local rfMRI connectivity in 32 aMCI patients compared with 40 healthy controls. We further used the seedbased functional connectivity to explore the remote rfMRI connectivity in aMCI. The results revealed significantly lower local connectivity in the default network and higher local connectivity in the somatomotor network in aMCI patients. Abnormal remote connectivity relevant to local connectivity was primarily detectable within the default network (decrease) and in the somatomotor and attention networks (increase). The abnormalities in the remote (not local) default network connectivity were significantly associated with episodic memory performance in patients. These distance-related connectivity profiles illustrated a dysfunctional pattern in aMCI, which extended our knowledge of this pathological aging process. (C) 2017 Elsevier Inc. All rights reserved.

KeywordAmnestic mild cognitive impairment Functional homogeneity Local connectivity Remote connectivity Default mode network
DOI10.1016/j.neurobiolaging.2017.04.016
Indexed BySCI ; SSCI ; SSCI
Language英语
Funding OrganizationNational Basic Research Program (973 Program)(2015CB351702) ; Chinese Academy of Sciences Youth Innovation Promotion Association(2016084) ; National Natural Science Foundation of China(81220108014 ; Beijing Municipal Science & Technology Commission(Z161100000216152) ; 81471740 ; 31000465 ; 31371007)
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000405463300015
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDEFAULT-MODE NETWORK ; RESTING-STATE FMRI ; POSTERIOR CINGULATE CORTEX ; ONSET ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; REGIONAL HOMOGENEITY ; MEMORY-TASK ; SYSTEMS NEUROSCIENCE ; EPISODIC RETRIEVAL ; BRAIN ACTIVITY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21638
Collection中国科学院行为科学重点实验室
Corresponding AuthorLi, Kuncheng; Li, Hui-Jie
Affiliation1.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
4.Beijing Key Lab Magnet Resonance Imaging & Brain, Beijing, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Lifespan Connectome & Behav Team, Beijing, Peoples R China
7.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yi-Wen,Zhao, Zhi-Lian,Qi, Zhigang,et al. Local-to-remote cortical connectivity in amnestic mild cognitive impairment[J]. NEUROBIOLOGY OF AGING,2017,56(0):138-149.
APA Zhang, Yi-Wen.,Zhao, Zhi-Lian.,Qi, Zhigang.,Hu, Yang.,Wang, Yin-Shan.,...&Zuo, Xi-Nian.(2017).Local-to-remote cortical connectivity in amnestic mild cognitive impairment.NEUROBIOLOGY OF AGING,56(0),138-149.
MLA Zhang, Yi-Wen,et al."Local-to-remote cortical connectivity in amnestic mild cognitive impairment".NEUROBIOLOGY OF AGING 56.0(2017):138-149.
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