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Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase
Zhang, Hai-tao1,2; Zhang, Zi-jian1,3; Mo, Wei-chuan1; Hu, Ping-dong1,2; Ding, Hai-min3; Liu, Ying1,2; Hua, Qian3; He, Rong-qiao1,2,4
摘要

Accumulative evidence has shown the adverse effects of a geomagnetic field shielded condition, so called a hypomagnetic field (HMF), on the metabolic processes and oxidative stress in animals and cells. However, the underlying mechanism remains unclear. In this study, we evaluate the role of HMF on the regulation of cellular reactive oxygen species (ROS) in human neuroblastoma SH-SY5Y cells. We found that HMF exposure led to ROS decrease, and that restoring the decrease by additional H2O2 rescued the HMF-enhanced cell proliferation. The measurements on ROS related indexes, including total anti-oxidant capacity, H2O2 and superoxide anion levels, and superoxide dismutase (SOD) activity and expression, indicated that the HMF reduced H2O2 production and inhibited the activity of CuZn-SOD. Moreover, the HMF accelerated the denaturation of CuZn-SOD as well as enhanced aggregation of CuZn-SOD protein, in vitro. Our findings indicate that CuZn-SOD is able to response to the HMF stress and suggest it a mediator of the HMF effect.

关键词hypomagnetic field reactive oxygen species hydrogen peroxide superoxide dismutase oxidative stress
2017-07-01
语种英语
DOI10.1007/s13238-017-0403-9
发表期刊PROTEIN & CELL
ISSN1674-800X
卷号8期号:7页码:527-537
期刊论文类型Article
收录类别SCI
WOS关键词ZERO MAGNETIC-FIELD ; HYPOMAGNETIC FIELD ; HYPOGEOMAGNETIC FIELD ; FREE-RADICALS ; IN-VITRO ; MICE ; PROLIFERATION ; AGGREGATION ; EMBRYOS ; GROWTH
WOS标题词Science & Technology ; Life Sciences & Biomedicine
WOS研究方向Cell Biology
WOS类目Cell Biology
WOS记录号WOS:000404932900006
资助机构External Cooperation Program of BIC, Chinese Academy of Sciences(GJHZ201302) ; National Natural Science Foundation of China(31200628)
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21641
专题脑与认知科学国家重点实验室
作者单位1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Beijing Univ Chinese Med, Inst Beijing Chinese Tradit Med, Beijing 100029, Peoples R China
4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
第一作者单位脑与认知科学国家重点实验室
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Zhang, Hai-tao,Zhang, Zi-jian,Mo, Wei-chuan,et al. Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase[J]. PROTEIN & CELL,2017,8(7):527-537.
APA Zhang, Hai-tao.,Zhang, Zi-jian.,Mo, Wei-chuan.,Hu, Ping-dong.,Ding, Hai-min.,...&He, Rong-qiao.(2017).Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase.PROTEIN & CELL,8(7),527-537.
MLA Zhang, Hai-tao,et al."Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase".PROTEIN & CELL 8.7(2017):527-537.
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