Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase | |
Zhang, Hai-tao1,2; Zhang, Zi-jian1,3; Mo, Wei-chuan1; Hu, Ping-dong1,2; Ding, Hai-min3; Liu, Ying1,2; Hua, Qian3; He, Rong-qiao1,2,4 | |
摘要 | Accumulative evidence has shown the adverse effects of a geomagnetic field shielded condition, so called a hypomagnetic field (HMF), on the metabolic processes and oxidative stress in animals and cells. However, the underlying mechanism remains unclear. In this study, we evaluate the role of HMF on the regulation of cellular reactive oxygen species (ROS) in human neuroblastoma SH-SY5Y cells. We found that HMF exposure led to ROS decrease, and that restoring the decrease by additional H2O2 rescued the HMF-enhanced cell proliferation. The measurements on ROS related indexes, including total anti-oxidant capacity, H2O2 and superoxide anion levels, and superoxide dismutase (SOD) activity and expression, indicated that the HMF reduced H2O2 production and inhibited the activity of CuZn-SOD. Moreover, the HMF accelerated the denaturation of CuZn-SOD as well as enhanced aggregation of CuZn-SOD protein, in vitro. Our findings indicate that CuZn-SOD is able to response to the HMF stress and suggest it a mediator of the HMF effect. |
关键词 | hypomagnetic field reactive oxygen species hydrogen peroxide superoxide dismutase oxidative stress |
2017-07-01 | |
语种 | 英语 |
DOI | 10.1007/s13238-017-0403-9 |
发表期刊 | PROTEIN & CELL |
ISSN | 1674-800X |
卷号 | 8期号:7页码:527-537 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | ZERO MAGNETIC-FIELD ; HYPOMAGNETIC FIELD ; HYPOGEOMAGNETIC FIELD ; FREE-RADICALS ; IN-VITRO ; MICE ; PROLIFERATION ; AGGREGATION ; EMBRYOS ; GROWTH |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Cell Biology |
WOS类目 | Cell Biology |
WOS记录号 | WOS:000404932900006 |
资助机构 | External Cooperation Program of BIC, Chinese Academy of Sciences(GJHZ201302) ; National Natural Science Foundation of China(31200628) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/21641 |
专题 | 脑与认知科学国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Univ Chinese Med, Inst Beijing Chinese Tradit Med, Beijing 100029, Peoples R China 4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China |
第一作者单位 | 脑与认知科学国家重点实验室 |
推荐引用方式 GB/T 7714 | Zhang, Hai-tao,Zhang, Zi-jian,Mo, Wei-chuan,et al. Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase[J]. PROTEIN & CELL,2017,8(7):527-537. |
APA | Zhang, Hai-tao.,Zhang, Zi-jian.,Mo, Wei-chuan.,Hu, Ping-dong.,Ding, Hai-min.,...&He, Rong-qiao.(2017).Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase.PROTEIN & CELL,8(7),527-537. |
MLA | Zhang, Hai-tao,et al."Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase".PROTEIN & CELL 8.7(2017):527-537. |
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