PSYCH OpenIR  > 脑与认知科学国家重点实验室
Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase
Zhang, Hai-tao1,2; Zhang, Zi-jian1,3; Mo, Wei-chuan1; Hu, Ping-dong1,2; Ding, Hai-min3; Liu, Ying1,2; Hua, Qian3; He, Rong-qiao1,2,4
2017-07-01
发表期刊PROTEIN & CELL
ISSN1674-800X
文章类型Article
卷号8期号:7页码:527-537
摘要

Accumulative evidence has shown the adverse effects of a geomagnetic field shielded condition, so called a hypomagnetic field (HMF), on the metabolic processes and oxidative stress in animals and cells. However, the underlying mechanism remains unclear. In this study, we evaluate the role of HMF on the regulation of cellular reactive oxygen species (ROS) in human neuroblastoma SH-SY5Y cells. We found that HMF exposure led to ROS decrease, and that restoring the decrease by additional H2O2 rescued the HMF-enhanced cell proliferation. The measurements on ROS related indexes, including total anti-oxidant capacity, H2O2 and superoxide anion levels, and superoxide dismutase (SOD) activity and expression, indicated that the HMF reduced H2O2 production and inhibited the activity of CuZn-SOD. Moreover, the HMF accelerated the denaturation of CuZn-SOD as well as enhanced aggregation of CuZn-SOD protein, in vitro. Our findings indicate that CuZn-SOD is able to response to the HMF stress and suggest it a mediator of the HMF effect.

关键词hypomagnetic field reactive oxygen species hydrogen peroxide superoxide dismutase oxidative stress
DOI10.1007/s13238-017-0403-9
收录类别SCI
语种英语
项目资助者External Cooperation Program of BIC, Chinese Academy of Sciences(GJHZ201302) ; National Natural Science Foundation of China(31200628)
WOS研究方向Cell Biology
WOS类目Cell Biology
WOS记录号WOS:000404932900006
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ZERO MAGNETIC-FIELD ; HYPOMAGNETIC FIELD ; HYPOGEOMAGNETIC FIELD ; FREE-RADICALS ; IN-VITRO ; MICE ; PROLIFERATION ; AGGREGATION ; EMBRYOS ; GROWTH
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21641
专题脑与认知科学国家重点实验室
作者单位1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Beijing Univ Chinese Med, Inst Beijing Chinese Tradit Med, Beijing 100029, Peoples R China
4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Hai-tao,Zhang, Zi-jian,Mo, Wei-chuan,et al. Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase[J]. PROTEIN & CELL,2017,8(7):527-537.
APA Zhang, Hai-tao.,Zhang, Zi-jian.,Mo, Wei-chuan.,Hu, Ping-dong.,Ding, Hai-min.,...&He, Rong-qiao.(2017).Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase.PROTEIN & CELL,8(7),527-537.
MLA Zhang, Hai-tao,et al."Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase".PROTEIN & CELL 8.7(2017):527-537.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Shielding of the geo(964KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Hai-tao]的文章
[Zhang, Zi-jian]的文章
[Mo, Wei-chuan]的文章
百度学术
百度学术中相似的文章
[Zhang, Hai-tao]的文章
[Zhang, Zi-jian]的文章
[Mo, Wei-chuan]的文章
必应学术
必应学术中相似的文章
[Zhang, Hai-tao]的文章
[Zhang, Zi-jian]的文章
[Mo, Wei-chuan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。