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Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase
Zhang, Hai-tao1,2; Zhang, Zi-jian1,3; Mo, Wei-chuan1; Hu, Ping-dong1,2; Ding, Hai-min3; Liu, Ying1,2; Hua, Qian3; He, Rong-qiao1,2,4
2017-07-01
Source PublicationPROTEIN & CELL
ISSN1674-800X
SubtypeArticle
Volume8Issue:7Pages:527-537
Abstract

Accumulative evidence has shown the adverse effects of a geomagnetic field shielded condition, so called a hypomagnetic field (HMF), on the metabolic processes and oxidative stress in animals and cells. However, the underlying mechanism remains unclear. In this study, we evaluate the role of HMF on the regulation of cellular reactive oxygen species (ROS) in human neuroblastoma SH-SY5Y cells. We found that HMF exposure led to ROS decrease, and that restoring the decrease by additional H2O2 rescued the HMF-enhanced cell proliferation. The measurements on ROS related indexes, including total anti-oxidant capacity, H2O2 and superoxide anion levels, and superoxide dismutase (SOD) activity and expression, indicated that the HMF reduced H2O2 production and inhibited the activity of CuZn-SOD. Moreover, the HMF accelerated the denaturation of CuZn-SOD as well as enhanced aggregation of CuZn-SOD protein, in vitro. Our findings indicate that CuZn-SOD is able to response to the HMF stress and suggest it a mediator of the HMF effect.

Keywordhypomagnetic field reactive oxygen species hydrogen peroxide superoxide dismutase oxidative stress
DOI10.1007/s13238-017-0403-9
Indexed BySCI
Language英语
Funding OrganizationExternal Cooperation Program of BIC, Chinese Academy of Sciences(GJHZ201302) ; National Natural Science Foundation of China(31200628)
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000404932900006
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordZERO MAGNETIC-FIELD ; HYPOMAGNETIC FIELD ; HYPOGEOMAGNETIC FIELD ; FREE-RADICALS ; IN-VITRO ; MICE ; PROLIFERATION ; AGGREGATION ; EMBRYOS ; GROWTH
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21641
Collection脑与认知科学国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Beijing Univ Chinese Med, Inst Beijing Chinese Tradit Med, Beijing 100029, Peoples R China
4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
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Zhang, Hai-tao,Zhang, Zi-jian,Mo, Wei-chuan,et al. Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase[J]. PROTEIN & CELL,2017,8(7):527-537.
APA Zhang, Hai-tao.,Zhang, Zi-jian.,Mo, Wei-chuan.,Hu, Ping-dong.,Ding, Hai-min.,...&He, Rong-qiao.(2017).Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase.PROTEIN & CELL,8(7),527-537.
MLA Zhang, Hai-tao,et al."Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase".PROTEIN & CELL 8.7(2017):527-537.
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