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Identifying Topological Motif Patterns of Human Brain Functional Networks
Wei, Yongbin1,2,3; Liao, Xuhong1,2,4; Yan, Chaogan5,6; He, Yong1,2,4; Xia, Mingrui1,2,4
2017-05-01
发表期刊HUMAN BRAIN MAPPING
ISSN1065-9471
文章类型Article
卷号38期号:5页码:2734-2750
摘要

Recent imaging connectome studies demonstrated that the human functional brain network follows an efficient small-world topology with cohesive functional modules and highly connected hubs. However, the functional motif patterns that represent the underlying information flow remain largely unknown. Here, we investigated motif patterns within directed human functional brain networks, which were derived from resting-state functional magnetic resonance imaging data with controlled confounding hemodynamic latencies. We found several significantly recurring motifs within the network, including the two-node reciprocal motif and five classes of three-node motifs. These recurring motifs were distributed in distinct patterns to support intra-and inter-module functional connectivity, which also promoted integration and segregation in network organization. Moreover, the significant participation of several functional hubs in the recurring motifs exhibited their critical role in global integration. Collectively, our findings highlight the basic architecture governing brain network organization and provide insight into the information flow mechanism underlying intrinsic brain activities. (C) 2017 Wiley Periodicals, Inc.

关键词connectome magnetic resonance imaging directed network resting-state breath-holding
DOI10.1002/hbm.23557
收录类别SCI
语种英语
项目资助者Natural Science Foundation of China(81401479 ; Beijing Natural Science Foundation(Z151100003915082 ; Fundamental Research Funds for the Central Universities(2015KJJCA13) ; Hundred Talents Program of the Chinese Academy of Sciences ; 81671767 ; Z161100000216152 ; 91432115 ; Z161100000216125) ; 31521063 ; 11205041 ; 81671774)
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000404938700030
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]BOLD FMRI ; SENSORY STIMULATION ; COMPLEX NETWORKS ; SIGNAL ; MRI ; NORMALIZATION ; ORGANIZATION ; ACTIVATION ; CAUSALITY ; SPACE
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21642
专题中国科学院行为科学重点实验室
作者单位1.Beijing Normal Univ, Natl Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
2.Beijing Normal Univ, McGovern Inst Brain Res, IDG, Beijing, Peoples R China
3.Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht, Netherlands
4.Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing 100875, Peoples R China
5.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wei, Yongbin,Liao, Xuhong,Yan, Chaogan,et al. Identifying Topological Motif Patterns of Human Brain Functional Networks[J]. HUMAN BRAIN MAPPING,2017,38(5):2734-2750.
APA Wei, Yongbin,Liao, Xuhong,Yan, Chaogan,He, Yong,&Xia, Mingrui.(2017).Identifying Topological Motif Patterns of Human Brain Functional Networks.HUMAN BRAIN MAPPING,38(5),2734-2750.
MLA Wei, Yongbin,et al."Identifying Topological Motif Patterns of Human Brain Functional Networks".HUMAN BRAIN MAPPING 38.5(2017):2734-2750.
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