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A drug-drug conditioning paradigm reveals multiple antipsychotic-nicotine interactions | |
Feng, Min1,2,4,5; Sparkman, Nathan L.3,5; Sui, Nan2; Li, Ming5 | |
摘要 | Clinical studies indicate a reciprocal impact between nicotine use and antipsychotic medications in patients with schizophrenia. The present study used a conditioned avoidance response (CAR) test (a behavioral test of antipsychotic effect) and examined the specific drug-drug interactions between nicotine and haloperidol or clozapine. Following acquisition of the avoidance response, rats were first tested under either vehicle, nicotine (0.2, 0.4 mg/kg, sc), haloperidol (0.025, 0.05 mg/kg, sc), clozapine (5.0, 10.0 mg/kg, sc), or a combination of nicotine and haloperidol or nicotine and clozapine for seven consecutive days. Afterward, they were challenged with nicotine (0.2 mg/kg), haloperidol (0.025 mg/kg), or clozapine (5.0 mg/kg) in the CAR to assess if haloperidol or clozapine affected the behavioral effect of nicotine on avoidance response and if nicotine altered the avoidance suppressive effect of haloperidol and clozapine. During the seven avoidance drug test days, nicotine did not alter the avoidance suppressive effect of haloperidol or clozapine. However, in the challenge test, prior nicotine treatment (0.2 mg/kg) attenuated haloperidol's (0.05 mg/kg) sensitized effect on avoidance response. On the other hand, prior haloperidol treatment increased nicotine's (0.2 mg/kg) avoidance disruptive effect, and even engendered nicotine 0.4 mg/kg to exhibit an acquired avoidance suppressive effect. The combined nicotine and clozapine treatment did not produce any detectable interactive effects on avoidance response and motor activity. These findings suggest that nicotine is capable of altering the long-term antipsychotic efficacy of haloperidol, while haloperidol can alter the behavioral effects of nicotine. Clozapine and nicotine are less likely to influence each other. |
关键词 | Antipsychotic drugs nicotine conditioned avoidance response drug-drug conditioning nicotine-antipsychotic drugs interaction rat schizophrenia |
2017-04-01 | |
语种 | 英语 |
DOI | 10.1177/0269881116681471 |
发表期刊 | JOURNAL OF PSYCHOPHARMACOLOGY |
ISSN | 0269-8811 |
卷号 | 31期号:4页码:474-486 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | AVOIDANCE-RESPONSE MODEL ; PHENCYCLIDINE-INDUCED HYPERLOCOMOTION ; INDUCED LOCOMOTOR SENSITIZATION ; BEHAVIORAL MECHANISMS ; CLOZAPINE TOLERANCE ; LINKING BIOLOGY ; RATS DIFFER ; SCHIZOPHRENIA ; HALOPERIDOL ; RISPERIDONE |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
WOS类目 | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
WOS记录号 | WOS:000400179400008 |
资助机构 | NIMH(R01MH085635) ; Chinese National Science Foundation(31428008) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/21651 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Biol, Dept Viral Immunol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 3.Stephen F Austin State Univ, Dept Psychol, Nacogdoches, TX 75962 USA 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 5.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA |
第一作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Feng, Min,Sparkman, Nathan L.,Sui, Nan,et al. A drug-drug conditioning paradigm reveals multiple antipsychotic-nicotine interactions[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2017,31(4):474-486. |
APA | Feng, Min,Sparkman, Nathan L.,Sui, Nan,&Li, Ming.(2017).A drug-drug conditioning paradigm reveals multiple antipsychotic-nicotine interactions.JOURNAL OF PSYCHOPHARMACOLOGY,31(4),474-486. |
MLA | Feng, Min,et al."A drug-drug conditioning paradigm reveals multiple antipsychotic-nicotine interactions".JOURNAL OF PSYCHOPHARMACOLOGY 31.4(2017):474-486. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
A drug drug conditio(1451KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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