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A drug-drug conditioning paradigm reveals multiple antipsychotic-nicotine interactions
Feng, Min1,2,4,5; Sparkman, Nathan L.3,5; Sui, Nan2; Li, Ming5
2017-04-01
发表期刊JOURNAL OF PSYCHOPHARMACOLOGY
ISSN0269-8811
文章类型Article
卷号31期号:4页码:474-486
摘要

Clinical studies indicate a reciprocal impact between nicotine use and antipsychotic medications in patients with schizophrenia. The present study used a conditioned avoidance response (CAR) test (a behavioral test of antipsychotic effect) and examined the specific drug-drug interactions between nicotine and haloperidol or clozapine. Following acquisition of the avoidance response, rats were first tested under either vehicle, nicotine (0.2, 0.4 mg/kg, sc), haloperidol (0.025, 0.05 mg/kg, sc), clozapine (5.0, 10.0 mg/kg, sc), or a combination of nicotine and haloperidol or nicotine and clozapine for seven consecutive days. Afterward, they were challenged with nicotine (0.2 mg/kg), haloperidol (0.025 mg/kg), or clozapine (5.0 mg/kg) in the CAR to assess if haloperidol or clozapine affected the behavioral effect of nicotine on avoidance response and if nicotine altered the avoidance suppressive effect of haloperidol and clozapine. During the seven avoidance drug test days, nicotine did not alter the avoidance suppressive effect of haloperidol or clozapine. However, in the challenge test, prior nicotine treatment (0.2 mg/kg) attenuated haloperidol's (0.05 mg/kg) sensitized effect on avoidance response. On the other hand, prior haloperidol treatment increased nicotine's (0.2 mg/kg) avoidance disruptive effect, and even engendered nicotine 0.4 mg/kg to exhibit an acquired avoidance suppressive effect. The combined nicotine and clozapine treatment did not produce any detectable interactive effects on avoidance response and motor activity. These findings suggest that nicotine is capable of altering the long-term antipsychotic efficacy of haloperidol, while haloperidol can alter the behavioral effects of nicotine. Clozapine and nicotine are less likely to influence each other.

关键词Antipsychotic drugs nicotine conditioned avoidance response drug-drug conditioning nicotine-antipsychotic drugs interaction rat schizophrenia
DOI10.1177/0269881116681471
收录类别SCI
语种英语
项目资助者NIMH(R01MH085635) ; Chinese National Science Foundation(31428008)
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000400179400008
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]AVOIDANCE-RESPONSE MODEL ; PHENCYCLIDINE-INDUCED HYPERLOCOMOTION ; INDUCED LOCOMOTOR SENSITIZATION ; BEHAVIORAL MECHANISMS ; CLOZAPINE TOLERANCE ; LINKING BIOLOGY ; RATS DIFFER ; SCHIZOPHRENIA ; HALOPERIDOL ; RISPERIDONE
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21651
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Biol, Dept Viral Immunol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
3.Stephen F Austin State Univ, Dept Psychol, Nacogdoches, TX 75962 USA
4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
5.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
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Feng, Min,Sparkman, Nathan L.,Sui, Nan,et al. A drug-drug conditioning paradigm reveals multiple antipsychotic-nicotine interactions[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2017,31(4):474-486.
APA Feng, Min,Sparkman, Nathan L.,Sui, Nan,&Li, Ming.(2017).A drug-drug conditioning paradigm reveals multiple antipsychotic-nicotine interactions.JOURNAL OF PSYCHOPHARMACOLOGY,31(4),474-486.
MLA Feng, Min,et al."A drug-drug conditioning paradigm reveals multiple antipsychotic-nicotine interactions".JOURNAL OF PSYCHOPHARMACOLOGY 31.4(2017):474-486.
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