PSYCH OpenIR  > 健康与遗传心理学研究室
Alternative TitleClinical study on the treatment of anxiolytic compound prescription with Valerianae Jatamansi Rhizoma et Radix on generalized anxiety disorder
白俊爽1,2 ,张青川3 ,郭丹丹3 ,郑虎占4 ,石晋丽4* ,郭建友1,2*; 张青川3; 郭丹丹3; 郑虎占4; 石晋丽4; 郭建友1,2
First Author白俊爽
Source Publication中国中药杂志
Correspondent ;

观察复方马蹄香对肝气郁结、心神不宁型广泛性焦虑患者的临床疗效。选择67名属肝气郁结、心神不宁型的广泛性焦虑症患者,随机分为治疗组(34例)和对照组(33例),治疗组给予复方马蹄香,对照组给予黛力新治疗,2组均采用药物治疗4周。治疗前及治疗第2,4周采用汉密尔顿焦虑量表(HAMA)进行疗效评价;以中医证候量表(肝气郁结、心神不宁型)观察焦虑评分;同时取患者唾液测定皮质醇(cortisol)含量;并于治疗前和治疗4周后测量生活事件量表(LES),进行药物安全性评价。通过测量生活事件量表剔除2例患者,中止5名,最终共60例患者纳入该研究(每组30例)。2组患者HAMA总分在治疗第2,4周时均有所改善(P<0.05,P<0.01);中医证候量表积分改善情况在治疗2,4周后均具有显著统计学意义(P<0.01);唾液皮质醇水平在治疗第2,4周时均有所下降(P<0.05,P<0.01)。治疗2周后与4周后2组间比较总有效率无统计学意义差异,HAMA积分、中医证候量表积分、唾液皮质醇水平改善方面组间差异也均无统计学差异。不良反应发生率方面,治疗组(6.67%)低于对照组(... 更多

Other Abstract

[Abstract] This study was aimed to observe the clinical efficacy of anxiolytic compound prescription with Valerianae Jatamansi Rhizoma et Radix(ACPV) in treating generalized anxiety disorder(GAD). Sixty-seven patients diagnosed as GAD with stagnation of liver qi and feel ill at ease type were randomly divided into treatment group and control group. Patients in treatment group (n=34) was treated with ACPV decoction, and patients in control group (n=33) were treated with deanxit. Both groups were treated with respective drugs for 4 weeks. HAMA scale, traditional Chinese medicine (TCM) symptom scale  and salivary cortisol levels were measured before and 2 weeks and 4 weeks after drug treatment. The life events scale (LES) and drug safety evaluation were performed before and after 4 weeks treatment. Two patients were excluded according to LES, and 5 patients were discontinued. Sixty patients were enrolled in the study (30 cases each). Compared with baseline, HAMA scores in both groups were significantly decreased at 2 weeks and 4 weeks (P<0.05 and P<0.01, respectively). After 2 weeks and 4 weeks treatment, the TCM syndrome in both group was also significantly reduced (P< 0.01). Moreover, the salivary cortisol levels in both groups were also decreased at 2 weeks and 4 weeks (P<0.05 and P<0.01, respectively). The total efficiency between two groups had no statistically significant difference after 2 weeks treatment and 4 weeks treatment; Moreover, no statistically significant differences were observed between two groups in HAMA scores, TCM syndrome scale scores and salivary cortisol levels. The incidence of adverse reactions in the treatment group(6.67%) was significantly lower than that in the control group (13.3%), (P<0.01), and there were no obvious side effects on general physical examination during the period of treatment. Thus, anxiolytic compound prescription with Valerianae Jatamansi Rhizoma et Radix is effective for GAD (stagnation of liver qi and feel ill at ease type).

Keyword复方马蹄香 广泛性焦虑 肝气郁结 心神不宁 临床研究
Indexed ByCSCD
Funding Organization科技部“重大新药创制”科技重大专项(2012ZX09102201-018)
Citation statistics
Document Type期刊论文
Corresponding Author石晋丽; 郭建友
Affiliation1.中国科学院心理健康重点实验室, 中国科学院心理研究所
4.北京中医药大学 中药学院
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
白俊爽1,2 ,张青川3 ,郭丹丹3 ,郑虎占4 ,石晋丽4* ,郭建友1,2*,张青川,郭丹丹,等. 复方马蹄香治疗广泛性焦虑症的临床研究[J]. 中国中药杂志,2017(9):1-10.
APA 白俊爽1,2 ,张青川3 ,郭丹丹3 ,郑虎占4 ,石晋丽4* ,郭建友1,2*,张青川,郭丹丹,郑虎占,石晋丽,&郭建友.(2017).复方马蹄香治疗广泛性焦虑症的临床研究.中国中药杂志(9),1-10.
MLA 白俊爽1,2 ,张青川3 ,郭丹丹3 ,郑虎占4 ,石晋丽4* ,郭建友1,2*,et al."复方马蹄香治疗广泛性焦虑症的临床研究".中国中药杂志 .9(2017):1-10.
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