PSYCH OpenIR  > 健康与遗传心理学研究室
帕金森症与肠道微生物
Alternative TitleParkinson's disease and gut microbiota
李薇1,2; 胡旭1; 王涛1; 秦斌3; 金锋1
Correspondent Emailviviclw@gmail com ; jinlcng@ psych. ac. cn
Abstract

帕金森症是一种多发于中老年期的、慢性的、进行性的、可致残的神经系统退行性疾病。近年来许多研究发现帕金森症患者的胃肠道症状往往早于运动症状数年出现并在早期帕金森症患者的肠神经系统内发现病理组织学改变,提示肠道可能是帕金森病理早期发生的位置。肠道微生物作为与人体共生的最大微生物群落,不仅影响宿主的营养吸收和能量代谢,促进免疫系统发育和调节肠黏膜免疫系统,促进和抑制炎症反应,还可以通过肠—脑轴影响中枢神经系统,还可能是导致神经系统退行性病变发生的原因之一。目前已有研究发现帕金森症患者的肠道微生物与健康对照之间差异有统计学意义,提示从改善肠道微生物的角度入手,通过益生菌干预来恢复肠道微生态的平衡可能成为治疗帕金森症的一种新方法。

Other Abstract

Parkinson’s disease CPD) is a chronic, progressive,disabling ncurodegenerative disorder that be    gins in mid to late life. Recently, many studies found that gastrointestinal dysfunction developed earlier than the onset of parkinsonian motor symptoms; and histopathological changes were found in the enteric nervous system of early PD patients, indicating that PD pathology may occur in the gut at early stage.  As the largest microbial flora inhabited in human body, the gut microbiota could influence the nutrition absorption and encrgy metabolism of the host,facilitate the development of the immune system and modulate the enteric mucoral immune system, promote and inhibit inflammation, and could affect the central nervous system via the gut-brain axis, thus, might lead to the ncurodegenerative diseases.  Research found that the gut microbiota between PD patients and healthy controls were significantly different,suggesting that to improve the gut microbiota and restore the balance of gut microccology by probiotic supplement could be a promising therapy for PD.

Keyword肠道微生物 帕金森症 α-突触核蛋白 胃肠道功能障碍 肠-脑轴
2017
Language中文
DOI10.13381/j.cnki.cjm.201707024
Source Publication中国微生态学杂志
ISSN1005-376X
Volume29Issue:7Pages:844-849
Subtype期刊论文
URL查看原文
Indexed ByCSCD
CSCD IDCSCD:6034990
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21770
Collection健康与遗传心理学研究室
Corresponding Author李薇; 金锋
Affiliation1.中国科学院心理研究所心理健康重点实验室
2.中国科学院大学
3.北京医院神经内科
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
李薇,胡旭,王涛,等. 帕金森症与肠道微生物[J]. 中国微生态学杂志,2017,29(7):844-849.
APA 李薇,胡旭,王涛,秦斌,&金锋.(2017).帕金森症与肠道微生物.中国微生态学杂志,29(7),844-849.
MLA 李薇,et al."帕金森症与肠道微生物".中国微生态学杂志 29.7(2017):844-849.
Files in This Item:
File Name/Size DocType Version Access License
帕金森症与肠道微生物_李薇.pdf(315KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[李薇]'s Articles
[胡旭]'s Articles
[王涛]'s Articles
Baidu academic
Similar articles in Baidu academic
[李薇]'s Articles
[胡旭]'s Articles
[王涛]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[李薇]'s Articles
[胡旭]'s Articles
[王涛]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.