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Alternative TitleBrain mechanisms of Conditioned Immunosuppression
Degree Grantor中国科学院研究生院
Place of Conferral北京
Degree Discipline生物心理学
Keyword条件反射性免疫抑制 c-fos 脑机制


Other Abstract

    Conditioned immunosuppression (CIS) using a taste aversion paradigm(CTA) has been demonstrated in a number of laboratory models, but little is known about the central mechanisms of CIS. By using c一fos protein production as a marker of neuronal activation, the present work att}.mpts to localize the brain regions involved in the neural mechanism of CIS. CTA and CIS were established by intake of saccharin as the conditioned stimulus (CS) with an injection of cyclophosphamide as an unconditioned stimulus (UCS). After animals were reexposed to CS alone at intervals of 5 or 30 days after two trials of CS-UCS pairing, both CTA and CIS- were assessed and the expression of c一s protein in the brain was also observed correspondingly. The results showed that CTA occurred on both day 5 and day 30 after conditioning but CIS occurred only on day 5 after conditioning. Furthermore, it was found that intensive c一s expression in .the hypothalamus paraventricular nucleus (PVN),the amygdaloid central (Ce), the granular insular cortex(GI) in the CS group was observed at the 5 days interval and a few c一s immunoreactive inductions at the 30 days interval after re-exposure to CS. By comparing the results of the 5th day with the 30th day, it suggests that the PVN is an important nucleus related to the modulation of CIS, the Ce and GI are involved in CTA and CIS.

Subject Area心理学
Document Type学位论文
Recommended Citation
GB/T 7714
李杰. 条件反射性免疫抑制脑机制研究[D]. 北京. 中国科学院研究生院,2004.
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