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Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study
Liu, Jixin1,2; Liu, Hongjuan3; Mu, Junya1,2; Xu, Qing1,2; Chen, Tao1,2; Dun, Wanghuan3; Yang, Jing3; Tian, Jie1,2; Hu, Li4,5,6; Zhang, Ming3
2017-09-01
发表期刊HUMAN BRAIN MAPPING
通讯作者邮箱huli@psych.ac.cn
ISSN1065-9471
文章类型Article
卷号38期号:9页码:4430-4443
摘要

Primary dysmenorrhea (PD), as characterized by painful menstrual cramps without organic causes, is associated with central sensitization and brain function changes. Previous studies showed the integrated role of the default mode network (DMN) in the pain connectome and its key contribution on how an individual perceives and copes with pain disorders. Here, we aimed to investigate whether the cingulum bundle connecting hub regions of the DMN was disrupted in young women with PD. Diffusion tensor imaging was obtained in 41 PD patients and 41 matched healthy controls (HC) during their periovulatory phase. The production of prostaglandins (PGs) was obtained in PD patients during their pain-free and pain phases. As compared with HC, PD patients had similar scores of pain intensity, anxiety, and depression in their pain-free phase. However, altered white matter properties mainly located in the posterior section of the cingulum bundle were observed in PD. Besides PGs being related to menstrual pain, a close relationship was found between the white matter properties of the cingulum bundle during the pain-free phase and the severity of the menstrual pain in PD patients. Our study suggested that PD had trait changes of white matter integrities in the cingulum bundle that persisted beyond the time of menstruation. We inferred that altered anatomical connections may lead to less-flexible communication within the DMN, and/or between the DMN and other pain-related brain networks, which may result in the central susceptibility to develop chronic pain conditions in PD's later life. (C) 2017 Wiley Periodicals, Inc.

关键词primary dysmenorrhea diffusion tensor imaging cingulum bundle
DOI10.1002/hbm.23670
收录类别SCI
语种英语
项目资助者Science and Technology Planning Program of Henan Province(172106000074 ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China(81471737 ; Chongqing Research Program of Basic Research and Frontier Technology(cstc2015jcyjBX0050) ; 162102210218) ; 31471082 ; 31671141 ; 81501547 ; 81473603 ; 81571640 ; 81371530 ; 81301281)
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000407014700011
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]TENSOR IMAGING DETECTS ; FUNCTIONAL CONNECTIVITY ; MENSTRUAL PAIN ; FIBER TRACKING ; CLINICAL PAIN ; HUMAN BRAIN ; DIFFUSION ; BEHAVIOR ; PROGESTERONE ; ESTROGEN
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21893
专题中国科学院心理健康重点实验室
通讯作者Hu, Li
作者单位1.Xidian Univ, Sch Life Sci & Technol, Ctr Brain Imaging, Xian 710126, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710126, Shaanxi, Peoples R China
3.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Med Imaging, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
推荐引用方式
GB/T 7714
Liu, Jixin,Liu, Hongjuan,Mu, Junya,et al. Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study[J]. HUMAN BRAIN MAPPING,2017,38(9):4430-4443.
APA Liu, Jixin.,Liu, Hongjuan.,Mu, Junya.,Xu, Qing.,Chen, Tao.,...&Zhang, Ming.(2017).Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study.HUMAN BRAIN MAPPING,38(9),4430-4443.
MLA Liu, Jixin,et al."Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study".HUMAN BRAIN MAPPING 38.9(2017):4430-4443.
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