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Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study
Liu, Jixin1,2; Liu, Hongjuan3; Mu, Junya1,2; Xu, Qing1,2; Chen, Tao1,2; Dun, Wanghuan3; Yang, Jing3; Tian, Jie1,2; Hu, Li4,5,6; Zhang, Ming3
2017-09-01
Source PublicationHUMAN BRAIN MAPPING
Correspondent Emailhuli@psych.ac.cn
ISSN1065-9471
SubtypeArticle
Volume38Issue:9Pages:4430-4443
Abstract

Primary dysmenorrhea (PD), as characterized by painful menstrual cramps without organic causes, is associated with central sensitization and brain function changes. Previous studies showed the integrated role of the default mode network (DMN) in the pain connectome and its key contribution on how an individual perceives and copes with pain disorders. Here, we aimed to investigate whether the cingulum bundle connecting hub regions of the DMN was disrupted in young women with PD. Diffusion tensor imaging was obtained in 41 PD patients and 41 matched healthy controls (HC) during their periovulatory phase. The production of prostaglandins (PGs) was obtained in PD patients during their pain-free and pain phases. As compared with HC, PD patients had similar scores of pain intensity, anxiety, and depression in their pain-free phase. However, altered white matter properties mainly located in the posterior section of the cingulum bundle were observed in PD. Besides PGs being related to menstrual pain, a close relationship was found between the white matter properties of the cingulum bundle during the pain-free phase and the severity of the menstrual pain in PD patients. Our study suggested that PD had trait changes of white matter integrities in the cingulum bundle that persisted beyond the time of menstruation. We inferred that altered anatomical connections may lead to less-flexible communication within the DMN, and/or between the DMN and other pain-related brain networks, which may result in the central susceptibility to develop chronic pain conditions in PD's later life. (C) 2017 Wiley Periodicals, Inc.

Keywordprimary dysmenorrhea diffusion tensor imaging cingulum bundle
DOI10.1002/hbm.23670
Indexed BySCI
Language英语
Funding OrganizationScience and Technology Planning Program of Henan Province(172106000074 ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China(81471737 ; Chongqing Research Program of Basic Research and Frontier Technology(cstc2015jcyjBX0050) ; 162102210218) ; 31471082 ; 31671141 ; 81501547 ; 81473603 ; 81571640 ; 81371530 ; 81301281)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000407014700011
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordTENSOR IMAGING DETECTS ; FUNCTIONAL CONNECTIVITY ; MENSTRUAL PAIN ; FIBER TRACKING ; CLINICAL PAIN ; HUMAN BRAIN ; DIFFUSION ; BEHAVIOR ; PROGESTERONE ; ESTROGEN
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21893
Collection中国科学院心理健康重点实验室
Corresponding AuthorHu, Li
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Ctr Brain Imaging, Xian 710126, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710126, Shaanxi, Peoples R China
3.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Med Imaging, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Liu, Jixin,Liu, Hongjuan,Mu, Junya,et al. Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study[J]. HUMAN BRAIN MAPPING,2017,38(9):4430-4443.
APA Liu, Jixin.,Liu, Hongjuan.,Mu, Junya.,Xu, Qing.,Chen, Tao.,...&Zhang, Ming.(2017).Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study.HUMAN BRAIN MAPPING,38(9),4430-4443.
MLA Liu, Jixin,et al."Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study".HUMAN BRAIN MAPPING 38.9(2017):4430-4443.
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