Institutional Repository of Key Laboratory of Mental Health, CAS
Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study | |
Liu, Jixin1,2; Liu, Hongjuan3; Mu, Junya1,2; Xu, Qing1,2; Chen, Tao1,2; Dun, Wanghuan3; Yang, Jing3; Tian, Jie1,2; Hu, Li4,5,6; Zhang, Ming3 | |
通讯作者邮箱 | huli@psych.ac.cn |
摘要 | Primary dysmenorrhea (PD), as characterized by painful menstrual cramps without organic causes, is associated with central sensitization and brain function changes. Previous studies showed the integrated role of the default mode network (DMN) in the pain connectome and its key contribution on how an individual perceives and copes with pain disorders. Here, we aimed to investigate whether the cingulum bundle connecting hub regions of the DMN was disrupted in young women with PD. Diffusion tensor imaging was obtained in 41 PD patients and 41 matched healthy controls (HC) during their periovulatory phase. The production of prostaglandins (PGs) was obtained in PD patients during their pain-free and pain phases. As compared with HC, PD patients had similar scores of pain intensity, anxiety, and depression in their pain-free phase. However, altered white matter properties mainly located in the posterior section of the cingulum bundle were observed in PD. Besides PGs being related to menstrual pain, a close relationship was found between the white matter properties of the cingulum bundle during the pain-free phase and the severity of the menstrual pain in PD patients. Our study suggested that PD had trait changes of white matter integrities in the cingulum bundle that persisted beyond the time of menstruation. We inferred that altered anatomical connections may lead to less-flexible communication within the DMN, and/or between the DMN and other pain-related brain networks, which may result in the central susceptibility to develop chronic pain conditions in PD's later life. (C) 2017 Wiley Periodicals, Inc. |
关键词 | primary dysmenorrhea diffusion tensor imaging cingulum bundle |
2017-09-01 | |
语种 | 英语 |
DOI | 10.1002/hbm.23670 |
发表期刊 | HUMAN BRAIN MAPPING |
ISSN | 1065-9471 |
卷号 | 38期号:9页码:4430-4443 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | TENSOR IMAGING DETECTS ; FUNCTIONAL CONNECTIVITY ; MENSTRUAL PAIN ; FIBER TRACKING ; CLINICAL PAIN ; HUMAN BRAIN ; DIFFUSION ; BEHAVIOR ; PROGESTERONE ; ESTROGEN |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000407014700011 |
Q分类 | Q1 |
资助机构 | Science and Technology Planning Program of Henan Province(172106000074 ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China(81471737 ; Chongqing Research Program of Basic Research and Frontier Technology(cstc2015jcyjBX0050) ; 162102210218) ; 31471082 ; 31671141 ; 81501547 ; 81473603 ; 81571640 ; 81371530 ; 81301281) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/21893 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Hu, Li |
作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Ctr Brain Imaging, Xian 710126, Shaanxi, Peoples R China 2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710126, Shaanxi, Peoples R China 3.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Med Imaging, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Southwest Univ, Fac Psychol, Chongqing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Liu, Jixin,Liu, Hongjuan,Mu, Junya,et al. Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study[J]. HUMAN BRAIN MAPPING,2017,38(9):4430-4443. |
APA | Liu, Jixin.,Liu, Hongjuan.,Mu, Junya.,Xu, Qing.,Chen, Tao.,...&Zhang, Ming.(2017).Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study.HUMAN BRAIN MAPPING,38(9),4430-4443. |
MLA | Liu, Jixin,et al."Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study".HUMAN BRAIN MAPPING 38.9(2017):4430-4443. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Altered White Matter(912KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论