PSYCH OpenIR  > 中国科学院心理健康重点实验室
Alterations in brain activation in response to prolonged morphine withdrawal-induced behavioral inflexibility in rats
Piao, Chengji1,2,3; Liu, Tiane1,2; Ma, Lian1,2; Ding, Xuekun1,2; Wang, Xingyue1,2; Chen, Xing1,2; Duan, Ying1,2; Sui, Nan1,2; Liang, Jing1,2
第一作者Piao, Chengji ; Liu, Tiane
通讯作者邮箱suin@psych.ac.cn ; liangj@psych.ac.cn
心理所单位排序1
摘要

The inability to stop a repetitive maladaptive behavior is a main problem in addictive disorders. Neuroadaptations that are associated with behavioral inflexibility may be involved in compulsive drug use.

The aim of the present study was to investigate the pattern of behavioral inflexibility during morphine withdrawal and map brain activation that is linked to alterations in flexibility.

We first analyzed the effects of chronic morphine exposure on reversal learning after 2-week (short-term) and 6-week (prolonged) morphine withdrawal. We then compared the level of neuronal activation using cFos immunohistochemistry in 15 brain areas between rats that underwent morphine withdrawal and saline-control rats after a test of reversal learning.

Only prolonged morphine withdrawal impaired reversal learning. Rats that exhibited impairments in reversal learning presented a significant decrease in cFos expression in the orbitofrontal cortex (OFC), including the medial, lateral, and ventral OFC. cFos expression significantly increased in the dorsomedial striatum and major subregions of the medial prefrontal cortex (mPFC) in the morphine group. Rats that underwent prolonged morphine withdrawal exhibited no significant changes in cFos expression in the dorsolateral striatum, nucleus accumbens, amygdala, paraventricular thalamic nucleus, or motor cortex. The rats that underwent short-term withdrawal did not present any changes in cFos expression in any of these brain regions.

Altogether, these data suggest that alterations in the function of the frontal cortex and its striatal connections during the late morphine withdrawal phase may underlie the disruption of inhibitory control in opioid dependence.

关键词Morphine withdrawal Reversal learning Orbitalfrontal cortex Medial prefrontal cortex Striatum
2017-10-01
DOI10.1007/s00213-017-4689-3
发表期刊PSYCHOPHARMACOLOGY
ISSN0033-3158
卷号234期号:19页码:2941-2953
收录类别SCI
WOS关键词MEDIAL PREFRONTAL CORTEX ; COCAINE-EXPERIENCED RATS ; GLUR1 RECEPTOR SUBUNIT ; TIME-DEPENDENT CHANGES ; DORSOMEDIAL STRIATUM ; ORBITOFRONTAL CORTEX ; COGNITIVE FLEXIBILITY ; INDUCED REINSTATEMENT ; LEARNING-DEFICITS ; SIGNALING PATHWAY
WOS标题词Science & Technology ; Life Sciences & Biomedicine
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000409895900009
WOS分区Q1
资助机构National Natural Science Foundation of China(31271098 ; National Key Basic Research Program of China(2015CB553501) ; Beijing Natural Science Foundation(5162023) ; 31571108)
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21900
专题中国科学院心理健康重点实验室
通讯作者Sui, Nan; Liang, Jing
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Sinodanish Ctr Educ & Res, Beijing, Peoples R China
第一作者单位中国科学院心理健康重点实验室
通讯作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Piao, Chengji,Liu, Tiane,Ma, Lian,et al. Alterations in brain activation in response to prolonged morphine withdrawal-induced behavioral inflexibility in rats[J]. PSYCHOPHARMACOLOGY,2017,234(19):2941-2953.
APA Piao, Chengji.,Liu, Tiane.,Ma, Lian.,Ding, Xuekun.,Wang, Xingyue.,...&Liang, Jing.(2017).Alterations in brain activation in response to prolonged morphine withdrawal-induced behavioral inflexibility in rats.PSYCHOPHARMACOLOGY,234(19),2941-2953.
MLA Piao, Chengji,et al."Alterations in brain activation in response to prolonged morphine withdrawal-induced behavioral inflexibility in rats".PSYCHOPHARMACOLOGY 234.19(2017):2941-2953.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Alterations in brain(3153KB)期刊论文出版稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Piao, Chengji]的文章
[Liu, Tiane]的文章
[Ma, Lian]的文章
百度学术
百度学术中相似的文章
[Piao, Chengji]的文章
[Liu, Tiane]的文章
[Ma, Lian]的文章
必应学术
必应学术中相似的文章
[Piao, Chengji]的文章
[Liu, Tiane]的文章
[Ma, Lian]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。