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The effect of the muscarinic M-1 receptor antagonist biperiden on cognition in medication free subjects with psychosis | |
Vingerhoets, Claudia1,2; Bakker, Geor1,2; van Dijik, Jelske2; Bloemen, Oswald J. N.1,3; Wang, Ya4; Chan, Raymond C. K.4,5; Booij, Jan2; van Amelsvoort, Therese A. M. J.1; C. Vingerhoets | |
通讯作者邮箱 | claudia.vingerhoets@maastrichtuniversity.nl |
摘要 | The acetylcholine muscarinic M-1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M-1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M-1 receptor density is related to cognitive symptoms of psychosis. We investigated the role of the M-1 receptor in separate cognitive domains in subjects with a psychotic disorder using a muscarinic M-1 antagonist as an acute pharmacological challenge. 33 young subjects with a psychotic disorder and 30 gender, age and IQ matched healthy controls were enrolled. All participants completed a comprehensive cognitive test battery twice: once after placebo and once after oral administration of 4 mg. biperiden (M-1 antagonist). The order of drug administration was counterbalanced. Biperiden significantly negatively influenced both verbal (p<0.001 and p=0.032) and visual learning and memory (p = 0.028) in both groups. A medication x group interaction effect was found for reasoning and problem solving (p=0.005). No main or interaction effects were found for other cognitive domains. These results provide further in-vivo evidence that the M-1 receptor is involved in cognitive functioning, particularly verbal and visual memory processes. Lack of differential effects of biperiden between psychotic subjects and healthy controls may suggest that decreased M-1 receptor density is only present in chronic, older schizophrenia patients. However, it remains possible that differential effects of biperiden would be present in more severe cognitive impaired subjects with psychosis after several doses of biperiden instead of a single administration. (C) 2017 Elsevier B.V. and ECNP. All rights reserved. |
关键词 | Psychosis Muscarinic M-1 receptor Acetylcholine Cognition Biperiden |
2017-09-01 | |
语种 | 英语 |
DOI | 10.1016/j.euroneuro.2017.06.014 |
发表期刊 | EUROPEAN NEUROPSYCHOPHARMACOLOGY |
ISSN | 0924-977X |
卷号 | 27期号:9页码:854-864 |
期刊论文类型 | Article |
收录类别 | SCI ; SSCI |
WOS关键词 | HEALTHY-VOLUNTEERS ; PREFRONTAL CORTEX ; SCHIZOPHRENIA ; BINDING ; MEMORY ; PSYCHOPATHOLOGY ; RELIABILITY ; SENSITIVITY ; SCOPOLAMINE ; IMPAIRMENT |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
WOS类目 | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
WOS记录号 | WOS:000408676400003 |
资助机构 | Dutch Organization for Health Research and Development (ZonMw)(91112002) ; personal grant to Therese van Amelsvoort (ZONmW-VIDI)(91712394) ; Beijing Municipal Science & Technology Commission(Z161100000216138) ; National Basic Research Programme of China (Precision Psychiatry Programme)(2016YFC0906402) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/21905 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | C. Vingerhoets |
作者单位 | 1.Maastricht Univ, Dept Psychiat & Psychol, Vijverdalseweg 1, NL-6226 NB Maastricht, Netherlands 2.Acad Med Ctr, Dept Nucl Med, Amsterdam, Netherlands 3.GGZ Centraal, Ctr Mental Hlth Care Innova, Amersfoort, Netherlands 4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Vingerhoets, Claudia,Bakker, Geor,van Dijik, Jelske,et al. The effect of the muscarinic M-1 receptor antagonist biperiden on cognition in medication free subjects with psychosis[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2017,27(9):854-864. |
APA | Vingerhoets, Claudia.,Bakker, Geor.,van Dijik, Jelske.,Bloemen, Oswald J. N..,Wang, Ya.,...&C. Vingerhoets.(2017).The effect of the muscarinic M-1 receptor antagonist biperiden on cognition in medication free subjects with psychosis.EUROPEAN NEUROPSYCHOPHARMACOLOGY,27(9),854-864. |
MLA | Vingerhoets, Claudia,et al."The effect of the muscarinic M-1 receptor antagonist biperiden on cognition in medication free subjects with psychosis".EUROPEAN NEUROPSYCHOPHARMACOLOGY 27.9(2017):854-864. |
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