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The effect of the muscarinic M-1 receptor antagonist biperiden on cognition in medication free subjects with psychosis
Vingerhoets, Claudia1,2; Bakker, Geor1,2; van Dijik, Jelske2; Bloemen, Oswald J. N.1,3; Wang, Ya4; Chan, Raymond C. K.4,5; Booij, Jan2; van Amelsvoort, Therese A. M. J.1; C. Vingerhoets
2017-09-01
发表期刊EUROPEAN NEUROPSYCHOPHARMACOLOGY
通讯作者邮箱claudia.vingerhoets@maastrichtuniversity.nl
ISSN0924-977X
文章类型Article
卷号27期号:9页码:854-864
摘要

The acetylcholine muscarinic M-1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M-1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M-1 receptor density is related to cognitive symptoms of psychosis. We investigated the role of the M-1 receptor in separate cognitive domains in subjects with a psychotic disorder using a muscarinic M-1 antagonist as an acute pharmacological challenge. 33 young subjects with a psychotic disorder and 30 gender, age and IQ matched healthy controls were enrolled. All participants completed a comprehensive cognitive test battery twice: once after placebo and once after oral administration of 4 mg. biperiden (M-1 antagonist). The order of drug administration was counterbalanced. Biperiden significantly negatively influenced both verbal (p<0.001 and p=0.032) and visual learning and memory (p = 0.028) in both groups. A medication x group interaction effect was found for reasoning and problem solving (p=0.005). No main or interaction effects were found for other cognitive domains. These results provide further in-vivo evidence that the M-1 receptor is involved in cognitive functioning, particularly verbal and visual memory processes. Lack of differential effects of biperiden between psychotic subjects and healthy controls may suggest that decreased M-1 receptor density is only present in chronic, older schizophrenia patients. However, it remains possible that differential effects of biperiden would be present in more severe cognitive impaired subjects with psychosis after several doses of biperiden instead of a single administration. (C) 2017 Elsevier B.V. and ECNP. All rights reserved.

关键词Psychosis Muscarinic M-1 receptor Acetylcholine Cognition Biperiden
DOI10.1016/j.euroneuro.2017.06.014
收录类别SCI ; SSCI
语种英语
项目资助者Dutch Organization for Health Research and Development (ZonMw)(91112002) ; personal grant to Therese van Amelsvoort (ZONmW-VIDI)(91712394) ; Beijing Municipal Science & Technology Commission(Z161100000216138) ; National Basic Research Programme of China (Precision Psychiatry Programme)(2016YFC0906402)
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000408676400003
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]HEALTHY-VOLUNTEERS ; PREFRONTAL CORTEX ; SCHIZOPHRENIA ; BINDING ; MEMORY ; PSYCHOPATHOLOGY ; RELIABILITY ; SENSITIVITY ; SCOPOLAMINE ; IMPAIRMENT
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21905
专题中国科学院心理健康重点实验室
通讯作者C. Vingerhoets
作者单位1.Maastricht Univ, Dept Psychiat & Psychol, Vijverdalseweg 1, NL-6226 NB Maastricht, Netherlands
2.Acad Med Ctr, Dept Nucl Med, Amsterdam, Netherlands
3.GGZ Centraal, Ctr Mental Hlth Care Innova, Amersfoort, Netherlands
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
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GB/T 7714
Vingerhoets, Claudia,Bakker, Geor,van Dijik, Jelske,et al. The effect of the muscarinic M-1 receptor antagonist biperiden on cognition in medication free subjects with psychosis[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2017,27(9):854-864.
APA Vingerhoets, Claudia.,Bakker, Geor.,van Dijik, Jelske.,Bloemen, Oswald J. N..,Wang, Ya.,...&C. Vingerhoets.(2017).The effect of the muscarinic M-1 receptor antagonist biperiden on cognition in medication free subjects with psychosis.EUROPEAN NEUROPSYCHOPHARMACOLOGY,27(9),854-864.
MLA Vingerhoets, Claudia,et al."The effect of the muscarinic M-1 receptor antagonist biperiden on cognition in medication free subjects with psychosis".EUROPEAN NEUROPSYCHOPHARMACOLOGY 27.9(2017):854-864.
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