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Functional inactivation of dorsal medial striatum afters behavioral flexibility and recognition process in mice
Qiao, Yanhua1,2; Wang, Xingyue1,2; Ma, Lian1,2; Li, Shengguang1,2; Liang, Jing1,2
2017-10-01
Source PublicationPHYSIOLOGY & BEHAVIOR
ISSN0031-9384
SubtypeArticle
Volume179Issue:0Pages:467-477
Abstract

Deficits in behavioral flexibility and recognition memory are commonly observed in mental illnesses and neurodegenerative diseases. Abnormality of the striatum has been implicated in an association with the pathology of these diseases. However, the exact roles of striatal heterogeneous structures in these cognitive functions are still unknown. In the present study, we investigated the effects of suppressing neuronal activity in the dorsomedial striatum (DMStr) and nucleus accumbens core (NAcC) on reversal learning and novelty recognition in mice. In addition, the locomotor activity, anxiety-like behavior and social interaction were analyzed. Neuronal inactivation was performed by expressing lentivirus-mediated tetanus toxin (TeNT) in the target regions. The results showed that reversal learning was facilitated by neuronal inactivation in the DMStr but not the NAcC, which was attributable to accelerated extinction of acquired strategy but not to impaired memory retention. Furthermore, mice with NAcC inactivation spent more time exploring a novel object than a familiar one, comparable to control mice. In contrast, mice with DMStr inactivation exhibited no preference to a novel environment during the novel object or place recognition test. The DMStr mice also exhibited decreased anxiety level. No phenotypic effect was observed in the locomotion or social interaction in mice with either DMStr or NAcC inactivation. Altogether, these findings suggest that the DMStr but not the ventral area of the striatum plays a crucial role in learning and memory by coordinating spatial exploration as well as mediating information updating.

KeywordDorsomedial striatum Neuronal inactivation Recognition process Reversal learning Tetanus toxin light chain
DOI10.1016/j.physbeh.2017.07.026
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31571108) ; National Key Basic Research Program of China(2015CB553501) ; Beijing Natural Science Foundation(5162023)
WOS Research AreaPsychology ; Behavioral Sciences
WOS SubjectPsychology, Biological ; Behavioral Sciences
WOS IDWOS:000411533000061
WOS HeadingsSocial Sciences ; Science & Technology ; Life Sciences & Biomedicine
WOS KeywordNUCLEUS-ACCUMBENS CORE ; OBJECT RECOGNITION ; PREFRONTAL CORTEX ; VISUAL-DISCRIMINATION ; SYNAPTIC-TRANSMISSION ; DORSOMEDIAL STRIATUM ; PARKINSONS-DISEASE ; ANTERIOR CINGULATE ; SELECTIVE LESIONS ; RECEPTOR AGONIST
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21929
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Qiao, Yanhua,Wang, Xingyue,Ma, Lian,et al. Functional inactivation of dorsal medial striatum afters behavioral flexibility and recognition process in mice[J]. PHYSIOLOGY & BEHAVIOR,2017,179(0):467-477.
APA Qiao, Yanhua,Wang, Xingyue,Ma, Lian,Li, Shengguang,&Liang, Jing.(2017).Functional inactivation of dorsal medial striatum afters behavioral flexibility and recognition process in mice.PHYSIOLOGY & BEHAVIOR,179(0),467-477.
MLA Qiao, Yanhua,et al."Functional inactivation of dorsal medial striatum afters behavioral flexibility and recognition process in mice".PHYSIOLOGY & BEHAVIOR 179.0(2017):467-477.
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