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Altered Distant Synchronization of Background Network in Mild Cognitive Impairment during an Executive Function Task
Wang, Pengyun1,2; Li, Rui1,2; Yu, Jing3; Huang, Zirui4; Yan, Zhixiong5; Zhao, Ke1,2; Li, Juan1,2,6; Juan Li
2017-09-22
发表期刊FRONTIERS IN BEHAVIORAL NEUROSCIENCE
通讯作者邮箱lijuan@psych.ac.cn
ISSN1662-5153
文章类型Article
卷号11期号:0页码:1-9
Q分类Q1
产权排序1
摘要

Few studies to date have investigated the background network in the cognitive state relying on executive function in mild cognitive impairment (MCI) patients. Using the index of degree of centrality (DC), we explored distant synchronization of background network in MCI during a hybrid delayed-match-to-sample task (DMST), which mainly relies on the working memory component of executive function. We observed significant interactions between group and cognitive state in the bilateral posterior cingulate cortex (PCC) and the ventral subregion of precuneus. For normal control (NC) group, the long distance functional connectivity (FC) of the PCC/precuneus with the other regions of the brain was higher in rest state than that working memory state. For MCI patients, however, this pattern altered. There was no significant difference between rest and working memory state. The similar pattern was observed in the other cluster located in the right angular gyrus. To examine whether abnormal DC in PCC/precuneus and angular gyrus partially resulted from the deficit of FC between these regions and the other parts in the whole brain, we conducted a seed-based correlation analysis with these regions as seeds. The results indicated that the FC between bilateral PCC/precuneus and the right inferior parietal lobule (IPL) increased from rest to working memory state for NC participants. For MCI patients, however, there was no significant change between rest and working memory state. The similar pattern was observed for the FC between right angular gyrus and right anterior insula. However, there was no difference between MCI and NC groups in global efficiency and modularity. It may indicate a lack of efficient reorganization from rest state to a working memory state in the brain network of MCI patients. The present study demonstrates the altered distant synchronization of background network in MCI during a task relying on executive function. The results provide a new perspective regarding the neural mechanisms of executive function deficits in MCI patients, and extend our understanding of brain patterns in task-evoked cognitive states.

关键词mild cognitive impairment executive function background network degree of centrality working memory
DOI10.3389/fnbeh.2017.00174
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(31271108 ; Beijing Municipal Science & Technology Commission(Z171100000117006) ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program(TSS-2015-06) ; CAS Key Laboratory of Mental Health, Institute of Psychology(KLMH2014ZK02 ; 31470998 ; KLMH2014ZG10) ; 31671157 ; 31400895)
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000411949200001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]INTRINSIC CONNECTIVITY NETWORKS ; WORKING-MEMORY TASK ; ALZHEIMERS-DISEASE ; NEURAL MECHANISMS ; BRAIN ACTIVITY ; ATTENTION ; CENTRALITY ; FMRI ; PERFORMANCE ; HOMOGENEITY
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/21936
专题中国科学院心理健康重点实验室
通讯作者Juan Li
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Ctr Aging Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
4.Univ Ottawa, Inst Mental Hlth Res, Ottawa, ON, Canada
5.Guangxi Teachers Educ Univ, Sch Educ Sci, Nanning, Peoples R China
6.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
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Wang, Pengyun,Li, Rui,Yu, Jing,et al. Altered Distant Synchronization of Background Network in Mild Cognitive Impairment during an Executive Function Task[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2017,11(0):1-9.
APA Wang, Pengyun.,Li, Rui.,Yu, Jing.,Huang, Zirui.,Yan, Zhixiong.,...&Juan Li.(2017).Altered Distant Synchronization of Background Network in Mild Cognitive Impairment during an Executive Function Task.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,11(0),1-9.
MLA Wang, Pengyun,et al."Altered Distant Synchronization of Background Network in Mild Cognitive Impairment during an Executive Function Task".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 11.0(2017):1-9.
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