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Granger causality supports abnormal functional connectivity of beta oscillations in the dorsolateral striatum and substantia nigra pars reticulata in hemiparkinsonian rats
Wang, Qiang1,2; Li, Min1,2; Xie, Zhengyuan1,2; Cai, Junbin1,2; Li, Nanxiang1,2; Xiao, Hu1,2; Wang, Ning3; Wang, Jinyan3; Luo, Fei3; Zhang, Wangming1
2017-11-01
Source PublicationEXPERIMENTAL BRAIN RESEARCH
ISSN0014-4819
SubtypeArticle
Volume235Issue:11Pages:3357-3365
Abstract

Synchronized oscillatory neuronal activity in the beta frequency range has been reported in the basal ganglia (BG) of patients with Parkinson disease (PD) and PD animal models. The coherent abnormal oscillatory activities in the dorsolateral striatum (dStr) and substantia nigra pars reticulata (SNr) that accompany parkinsonian states have not been resolved. In this study, we recorded local field potentials (LFPs) in the dStr and SNr of 6-hydroxydopamine (6-OHDA)-induced dopamine (DA)-lesioned rats in an awake, resting state. Analyses of power spectral density and coherence data demonstrated augmented LFP power in the 24-36-Hz (high beta) range in both the dStr and SNr together with increased dStr-SNr coherence in the 24-36-Hz range, relative to sham controls; both effects were reversed by levodopa (l-dopa) treatment. Partial Granger causality analysis revealed a dStr -> SNr propagation directionality of these beta oscillations. These findings support the involvement of increased synchronization of high beta activity in the dStr and the SNr, and suggest that dorsolateral striatal activity plays a determinant role in leading the coherent activity with the SNr in the development of parkinsonian pathophysiology.

KeywordParkinson disease Parkinsonian rats Local field potentials Beta band oscillations Dorsolateral striatum Substantia nigra pars reticulate
DOI10.1007/s00221-017-5054-9
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81272150) ; Guangdong Provincial Clinical Medical Center for Neurosurgery(2013B020400005)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000413441500012
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordEXTERNAL GLOBUS-PALLIDUS ; DEEP BRAIN-STIMULATION ; SUBTHALAMIC NUCLEUS OSCILLATIONS ; PARKINSONS-DISEASE ; BASAL GANGLIA ; MOTOR CORTEX ; DOPAMINE DEPLETION ; CEREBRAL-CORTEX ; FREQUENCY SYNCHRONIZATION ; PEDUNCULOPONTINE NUCLEUS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21947
Collection中国科学院心理健康重点实验室
Affiliation1.Southern Med Univ, Guangdong Prov Key Lab Brain Funct Repair & Regen, Educ Minist China,Dept Neurosurg,Zhujiang Hosp, Engn Technol Res Ctr,Natl Key Clin Specialty, Guangzhou 510282, Guangdong, Peoples R China
2.Southern Med Univ, Grad Sch, Guangzhou 510515, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qiang,Li, Min,Xie, Zhengyuan,et al. Granger causality supports abnormal functional connectivity of beta oscillations in the dorsolateral striatum and substantia nigra pars reticulata in hemiparkinsonian rats[J]. EXPERIMENTAL BRAIN RESEARCH,2017,235(11):3357-3365.
APA Wang, Qiang.,Li, Min.,Xie, Zhengyuan.,Cai, Junbin.,Li, Nanxiang.,...&Zhang, Wangming.(2017).Granger causality supports abnormal functional connectivity of beta oscillations in the dorsolateral striatum and substantia nigra pars reticulata in hemiparkinsonian rats.EXPERIMENTAL BRAIN RESEARCH,235(11),3357-3365.
MLA Wang, Qiang,et al."Granger causality supports abnormal functional connectivity of beta oscillations in the dorsolateral striatum and substantia nigra pars reticulata in hemiparkinsonian rats".EXPERIMENTAL BRAIN RESEARCH 235.11(2017):3357-3365.
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