健康与遗传心理学研究室知识库

    中枢免疫对于神经系统内稳态的维持意义重大。免疫活性分子 TNFα 及其受体系统参与神经发育、突触可塑性和认知功能调节;  其表达异常,  无论过度或者不足都可能导致对脑功能和行为的不良影响。应激, 尤其是发育早期应激可能通过影响中枢 TNFα 的动态发展过程从而造成其功能的持续改变,  并与后期免疫相关的心理病理发生密切相关。未来研究需拓展中枢免疫与认知功能障碍之间的因果联系,  建立基于免疫调节的疾病防治新策略。

    Central immune activities exert important roles in maintaining homeostatic process of central nervous system. It has shown that the dynamically balance of brain TNFα participates in the regulation of neurodevelopment, synaptic plasticity and cognitive function by its receptor signaling, while imbalance of TNFα signaling, no matter excessive or insufficient,  can result in adverse effects on brain function and behavior. Stress, especially early stress, may disturb the dynamic development process of TNFα signaling and thus cause lasting alterations of its expression and receptor function, which strongly linked to the increasing incidences of immune-related psychopathological disorders in late life. Future studies are needed to deepen the understanding of causal relationships between central immunity and cognitive dysfunction, and establish new strategies for disease prevention and treatment based on immunoregulation.