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DNA表观遗传修饰在药物成瘾记忆中的作用及机制
Alternative TitleThe role and mechanisms of DNA epigenetic modification in drug related memory
张建军1,2; 蒋丰泽3; 隋南1,2
First Author张建军 ; 蒋丰泽
2017
Source Publication心理科学进展
Correspondent Emailsuin@psych.ac.cn
ISSN1671-3710
Subtype期刊论文
Volume25Issue:12Pages:2057–2062
Contribution Rank1
Abstract

DNA 表观遗传修饰主要包括 DNA 甲基转移酶介导的 DNA 甲基化和 10-11 易位酶介导的 DNA 去甲基化。这两种表观遗传修饰都可以响应环境刺激,  调控基因表达,  引起神经功能和行为的改变。已有大量研究表明 DNA 甲基化是调控成瘾记忆的重要机制之一,  近年来也发现 DNA 去甲基化参与调控恐惧记忆及成瘾行为,  提示 DNA 表观遗传修饰在成瘾记忆中的作用需要重新评估。本文将重点讨论 DNA 甲基化和去甲基化可能共同调控成瘾记忆,  探讨其调控机制,  并试图提出可深入的研究展望。

Other Abstract

DNA epigenetic modification includes DNA methylation, which was catalyzed by the DNA methyltransferase, and DNA demethylation, which was mediated by the Ten-eleven translocation enzymes. Both of them induce the changes of neural activity and behavior through responding environmental stimulus and regulating gene expression. Massive studies suggested that DNA methylation is one of the most important mechanisms in the drug related memory. In  recent years, it was found that DNA demethylation involved in controlling fear memory and addiction behavior. As a result, the effects of DNA epigenetic modification on drug related memory should be reassessed. This review focuses on the co-regulation of DNA methylation and demethylation in drug related memory, then we discuss the probable regulatory mechanisms and try to put forward the vista of further study.

KeywordDNA 甲基化 DNA 去甲基化 药物成瘾记忆
DOI10.3724/SP.J.1042.2017.02057
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization国家重点基础研究发展计划(2015CB553501), 国家自然科学基金(91332115 ; 31400880)资助
CSCD IDCSCD:6130750
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21960
Collection中国科学院心理健康重点实验室
Corresponding Author隋南
Affiliation1.中国科学院心理健康重点实验室(中国科学院心理研究所)
2.中国科学院大学心理学系
3.西南大学心理学部, 认知与人格教育部重点实验室
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
张建军,蒋丰泽,隋南. DNA表观遗传修饰在药物成瘾记忆中的作用及机制[J]. 心理科学进展,2017,25(12):2057–2062.
APA 张建军,蒋丰泽,&隋南.(2017).DNA表观遗传修饰在药物成瘾记忆中的作用及机制.心理科学进展,25(12),2057–2062.
MLA 张建军,et al."DNA表观遗传修饰在药物成瘾记忆中的作用及机制".心理科学进展 25.12(2017):2057–2062.
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