PSYCH OpenIR  > 健康与遗传心理学研究室
亲代孕前成瘾药物暴露对子代行为的影响及其表观遗传机制
Alternative TitleThe impact of the parental preconception exposure to addictive drugs on the offsprings’ behavior and the epigenetic mechanism
张克1,2; 段 颖1,2; 杜秀敏3
2017
Source Publication心理科学进展
Correspondent Emailduxiumin-312@126.com
ISSN1671-3710
Subtype期刊论文
Volume25Issue:10Pages:1791–1798
Abstract

    孕前成瘾药物暴露不仅危害使用者的身体健康,  而且会对子代的生理行为造成影响,  近年来研究发现表观遗传机制在其中发挥重要作用。孕前成瘾药物暴露会对子代的成瘾易感性和焦虑样行为造成影响,  引起子代的抑郁样行为和认知受损。这些现象可能是成瘾药物通过引起亲代生殖细胞内表观遗传修饰变化所致, 其中包括印记基因、神经递质系统、BDNF 三个方面的表观遗传修饰变化。此外,  未来除了加强以上三个方面基因的研究,  也需要增加其他方面基因的研究,  以及寻找能预测子代异常行为的表观遗传生物标志物。

Other Abstract

    Parental preconception exposure to addictive drugs influences not only parents themselves, but also their offsprings’ physiological function and behavior. In recent years, research shows that the epigenetic alterations play a vital role in abnormal behavior.  Parental preconception exposure to addictive drugs influences the offsprings’ susceptibility to drug addiction and anxiety-like behavior, induces offsprings’ depression-like behavior and cognitive impairment. Epigenetic alterations in germ cells induced by preconception exposure to addictive drugs contribute to the onset of offsprings’ abnormal behavior through the changes of imprinted gene, BDNF, and neurotransmitter system. Future studies, besides strengthening the above three aspects research, should pay attention  to other aspects of genes and to try to find the epigenetic biomarker in germ cells for the prediction of the offsprings’ abnormal behavior.

Keyword成瘾药物 孕前 表观遗传 生殖细胞
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization河北省教育厅重点课题项目(SD151092)资助。
CSCD IDCSCD:6081536
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/21969
Collection健康与遗传心理学研究室
Corresponding Author杜秀敏
Affiliation1.中国科学院心理健康重点实验室, 中国科学院心理研究所
2.中国科学院大学
3.河北大学教育学院
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
张克,段 颖,杜秀敏. 亲代孕前成瘾药物暴露对子代行为的影响及其表观遗传机制[J]. 心理科学进展,2017,25(10):1791–1798.
APA 张克,段 颖,&杜秀敏.(2017).亲代孕前成瘾药物暴露对子代行为的影响及其表观遗传机制.心理科学进展,25(10),1791–1798.
MLA 张克,et al."亲代孕前成瘾药物暴露对子代行为的影响及其表观遗传机制".心理科学进展 25.10(2017):1791–1798.
Files in This Item:
File Name/Size DocType Version Access License
亲代孕前成瘾药物暴露对子代行为的影响及其(1019KB)期刊论文出版稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[张克]'s Articles
[段 颖]'s Articles
[杜秀敏]'s Articles
Baidu academic
Similar articles in Baidu academic
[张克]'s Articles
[段 颖]'s Articles
[杜秀敏]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[张克]'s Articles
[段 颖]'s Articles
[杜秀敏]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 亲代孕前成瘾药物暴露对子代行为的影响及其表观遗传机制_张克.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.