Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system | |
Qiao, Haoyi1,2; Ye, Xiansheng3; Bai, Xiaoyu4; He, Jun5; Li, Tingli6; Zhang, Jia3; Zhang, Weiku2; Xu, Jiekun1 | |
摘要 | Theacrine (1,3,7,9-tetramethyluric acid), a purine alkaloid from Camellia assamica var. kucha, has diverse pharmacological properties, including sedative and hypnotic activities, anti-inflammatory and analgesic activities, antidepressant effects, and a protective effect against stress-provoked liver damage. The present study aims to investigate the possible mechanism of the hypnotic activity of theacrine. The results revealed that theacrine significantly enhanced pentobarbital-induced sleep at a dose of 3.0 mg/kg (i.g.) in mice. Sleep parameter analysis by EEG and EMG showed that theacrine obviously shortened wake time and increased NREM sleep time and that theacrine almost had no effect on REM sleep. Meanwhile, theacrine markedly attenuated caffeine (a nonselective antagonist of adenosine receptor)-induced insomnia. In pretreatment with the adenosine A(1) receptor antagonist DPCPX and the A(2A) receptor antagonist SCH 58261, theacrine significantly reversed the decrease in sleeping time in pentobarbital-treated mice. In addition, theacrine also markedly increased the adenosine content in the hippocampus of rats. These results suggested that theacrine might mediate the adenosine system to augment pentobarbital-induced sleep. |
关键词 | Theacrine Hypnotic Pentobarbital-induced sleep EEG and EMG Adenosine system |
2017-10-17 | |
语种 | 英语 |
DOI | 10.1016/j.neulet.2017.08.063 |
发表期刊 | NEUROSCIENCE LETTERS |
ISSN | 0304-3940 |
卷号 | 659期号:0页码:48-53 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | MICE ; BEHAVIORS ; INSOMNIA ; RATS |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000413883000008 |
资助机构 | National Natural Science Foundation of China(81473119 ; 81473590 ; 81274115) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/22024 |
专题 | 健康与遗传心理学研究室 |
作者单位 | 1.Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China 2.China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China 3.Beijing Univ Chinese Med, Sch Chinese Med Sci, Beijing 100029, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 5.China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China 6.Heilongjiang Univ Chinese Med, Sch Chinese Med Sci, Harbin 150040, Heilongjiang, Peoples R China |
推荐引用方式 GB/T 7714 | Qiao, Haoyi,Ye, Xiansheng,Bai, Xiaoyu,et al. Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system[J]. NEUROSCIENCE LETTERS,2017,659(0):48-53. |
APA | Qiao, Haoyi.,Ye, Xiansheng.,Bai, Xiaoyu.,He, Jun.,Li, Tingli.,...&Xu, Jiekun.(2017).Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system.NEUROSCIENCE LETTERS,659(0),48-53. |
MLA | Qiao, Haoyi,et al."Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system".NEUROSCIENCE LETTERS 659.0(2017):48-53. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Theacrine_ A purine (1409KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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