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Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system
Qiao, Haoyi1,2; Ye, Xiansheng3; Bai, Xiaoyu4; He, Jun5; Li, Tingli6; Zhang, Jia3; Zhang, Weiku2; Xu, Jiekun1
2017-10-17
发表期刊NEUROSCIENCE LETTERS
ISSN0304-3940
文章类型Article
卷号659期号:0页码:48-53
摘要

Theacrine (1,3,7,9-tetramethyluric acid), a purine alkaloid from Camellia assamica var. kucha, has diverse pharmacological properties, including sedative and hypnotic activities, anti-inflammatory and analgesic activities, antidepressant effects, and a protective effect against stress-provoked liver damage. The present study aims to investigate the possible mechanism of the hypnotic activity of theacrine. The results revealed that theacrine significantly enhanced pentobarbital-induced sleep at a dose of 3.0 mg/kg (i.g.) in mice. Sleep parameter analysis by EEG and EMG showed that theacrine obviously shortened wake time and increased NREM sleep time and that theacrine almost had no effect on REM sleep. Meanwhile, theacrine markedly attenuated caffeine (a nonselective antagonist of adenosine receptor)-induced insomnia. In pretreatment with the adenosine A(1) receptor antagonist DPCPX and the A(2A) receptor antagonist SCH 58261, theacrine significantly reversed the decrease in sleeping time in pentobarbital-treated mice. In addition, theacrine also markedly increased the adenosine content in the hippocampus of rats. These results suggested that theacrine might mediate the adenosine system to augment pentobarbital-induced sleep.

关键词Theacrine Hypnotic Pentobarbital-induced sleep EEG and EMG Adenosine system
DOI10.1016/j.neulet.2017.08.063
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81473119 ; 81473590 ; 81274115)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000413883000008
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]MICE ; BEHAVIORS ; INSOMNIA ; RATS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/22024
专题健康与遗传心理学研究室
作者单位1.Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China
2.China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China
3.Beijing Univ Chinese Med, Sch Chinese Med Sci, Beijing 100029, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China
6.Heilongjiang Univ Chinese Med, Sch Chinese Med Sci, Harbin 150040, Heilongjiang, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Haoyi,Ye, Xiansheng,Bai, Xiaoyu,et al. Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system[J]. NEUROSCIENCE LETTERS,2017,659(0):48-53.
APA Qiao, Haoyi.,Ye, Xiansheng.,Bai, Xiaoyu.,He, Jun.,Li, Tingli.,...&Xu, Jiekun.(2017).Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system.NEUROSCIENCE LETTERS,659(0),48-53.
MLA Qiao, Haoyi,et al."Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system".NEUROSCIENCE LETTERS 659.0(2017):48-53.
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