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Altered intrinsic functional brain architecture in female patients with bulimia nervosa
Wang, Li1,2,3; Kong, Qing-Mei1,2,3; Li, Ke4; Li, Xue-Ni1,2,3; Zeng, Ya-Wei4; Chen, Chao1,2,3; Qian, Ying1,2,3; Feng, Shi-Jie5; Li, Ji-Tao1,2,3; Su, Yun'Ai1,2,3; Correll, Christoph U.6,7,8; Mitchell, Philip B.9,10; Yan, Chao-Gan11,12,13; Zhang, Da-Rong1,2,3; Si, Tian-Mei1,2,3
2017-11-01
Source PublicationJOURNAL OF PSYCHIATRY & NEUROSCIENCE
ISSN1180-4882
SubtypeArticle
Volume42Issue:6Pages:414-423
Abstract

Background: Bulimia nervosa is a severe psychiatric syndrome with uncertain pathogenesis. Neural systems involved in sensorimotor and visual processing, reward and impulsive control may contribute to the binge eating and purging behaviours characterizing bulimia nervosa. However, little is known about the alterations of functional organization of whole brain networks in individuals with this disorder. Methods: We used - resting-state functional MRI and graph theory to characterize functional brain networks of unmedicated women with bulimia nervosa and healthy women. Results: We included 44 unmedicated women with bulimia nervosa and 44 healthy women in our analyses. Women with bulimia nervosa showed increased clustering coefficient and path length compared with control women. The nodal strength in patients with the disorder was higher in the sensorimotor and visual regions as well as the precuneus, but lower in - several subcortical regions, such as the hippocampus, parahippocampal gyrus and orbitofrontal cortex. Patients also showed hyperconnectivity primarily involving sensorimotor and unimodal visual association regions, but hypoconnectivity involving subcortical (striatum, thalamus), limbic (amygdala, hippocampus) and paralimbic (orbitofrontal cortex, parahippocampal gyrus) regions. The topological aberrations correlated significantly with scores of bulimia and drive for thinness and with body mass index. Limitations: We reruited patients with only acute bulimia nervosa, so it is unclear whether the topological abnormalities comprise vulnerability markers for the disorder developing or the changes associated with illness state. Conclusion: Our findings show altered intrinsic functional brain architecture, specifically abnormal global and local efficiency, as well as nodal- and network-level connectivity across sensorimotor, visual, subcortical and limbic systems in women with bulimia nervosa, suggesting that it is a disorder of dysfunctional integration among large-scale distributed brain regions. These abnormalities contribute to more comprehensive understanding of the neural mechanism underlying pathological eating and body perception in women with bulimia nervosa.

DOI10.1503/jpn.160183
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Key Technology RD Program(2015BAI13B01) ; Beijing Municipal Science and Technology Commission(D121100005012002 ; Doctoral Program of Higher Education of China(20130001110106) ; National Key Basic Research Program of China (973 Program)(2013CB531305) ; National Natural Science Foundation of China(81671774) ; Chinese Academy of Sciences ; Z161100000216152)
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectNeurosciences ; Psychiatry
WOS IDWOS:000417628300008
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordGRAPH-THEORETICAL ANALYSIS ; TEST-RETEST RELIABILITY ; ANOREXIA-NERVOSA ; EATING-DISORDERS ; BODY-IMAGE ; MAGNETIC-RESONANCE ; STRIATAL RESPONSE ; NETWORKS ; CONNECTIVITY ; FMRI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/22270
Collection中国科学院行为科学重点实验室
Affiliation1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Natl Clin Res Ctr Mental Hlth Disorders, Minist Hlth, Beijing, Peoples R China
3.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China
4.Peoples Liberat Army, Dept Radiol, Hosp 306, Beijing, Peoples R China
5.Shanxi Mental Hlth Ctr, Taiyuan, Shanxi, Peoples R China
6.Zucker Hillside Hosp, Psychiat Res, North Shore Long Isl Jewish Hlth Syst, Glen Oaks, NY USA
7.Hofstra Northwell Sch Med, Hempstead, NY USA
8.Feinstein Inst Med Res, Manhasset, NY USA
9.Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia
10.Black Dog Inst, Sydney, NSW, Australia
11.Chinese Acad Sci, Key Lab Behav Sci, Inst Psychol, Beijing, Peoples R China
12.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
13.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Li,Kong, Qing-Mei,Li, Ke,et al. Altered intrinsic functional brain architecture in female patients with bulimia nervosa[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2017,42(6):414-423.
APA Wang, Li.,Kong, Qing-Mei.,Li, Ke.,Li, Xue-Ni.,Zeng, Ya-Wei.,...&Si, Tian-Mei.(2017).Altered intrinsic functional brain architecture in female patients with bulimia nervosa.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,42(6),414-423.
MLA Wang, Li,et al."Altered intrinsic functional brain architecture in female patients with bulimia nervosa".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 42.6(2017):414-423.
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