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Distinctive Changes of L-Type Calcium Channels and Dopamine Receptors in the Dorsomedial and Dorsolateral Striatum after the Expression of Habitual Cocaine-Seeking Behavior in Rats
Shen, Fang1,2; Jin, Shubo1,2; Duan, Ying1,2; Liang, Jing1,2; Zhang, Meng3; Jiang, Fengze1,2; Sui, Nan1,2; N. Sui
First AuthorShen, Fang ; Jin, Shubo
2018-02-01
Source PublicationNEUROSCIENCE
Correspondent Emailsuin@psych.ac.cn
ISSN0306-4522
SubtypeArticle
Volume370Pages:139-147
QuartileQ2
Contribution Rank1
Abstract

Habitual drug-seeking behavior is essential in the transition from recreational drug use to compulsive drug use and is regulated by the dopamine (DA) system of the dorsal striatum (DS). However, a comparative study of the two subtypes of DA receptors, D1 receptors (D1R) and D2 receptors (D2R), which have opposite regulatory functions, in habitual drug-seeking behavior is absent. Moreover, the effects of L-type calcium channels (LTCCs) and the subtypes Ca(v)1.2 and Ca(v)1.3, which are downstream of D1R and D2R, respectively, on habitual drug-seeking behavior have yet to be revealed. Therefore, based on the establishment of habitual cocaine-seeking behavior with changeable fixed interval (FI) self-administration (SA) training in rats, we compared the distinctive changes in D1R vs. D2R and Ca(v)1.2 vs. Ca(v)1.3 in the expression of habitual cocaine-seeking behavior in the dorsomedial striatum (DMS) and dorsolateral striatum (DLS). Our results showed that approximately forty percent of the animals exhibited habitual behavior after cocaine SA training. In addition, the total and membrane Ca(v)1.2 and D1R in the DLS demonstrated higher expression, but the total and membrane Ca(v)1.3 and D2R in the DMS demonstrated lower expression in well-established cocaine habitual behavior animals compared with non-established habitual behavior animals. These results suggested that upregulation of D1R-Ca(v)1.2 signaling may enhance the function of the DLS and that inactivation of D2R-Ca(v)1.3 caused depressed activity in the DMS during expression of habitual cocaine-seeking behavior. The imbalanced function between the DMS and DLS, which causes a shift from the DMS to the DLS, may mediate habitual behaviors. (C) 2017 Published by Elsevier Ltd on behalf of IBRO.

KeywordCa(v)1.2 Ca(v)1.3 dopamine receptors cocaine habitual seeking DMS DLS
DOI10.1016/j.neuroscience.2017.07.049
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China Youth Fund(31500893) ; National Basic Research Program Grants(2015CB553501) ; National Natural Science Foundation(31170988) ; National Natural Science Foundation Major Research Plan program(91332115) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000422688200014
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDORSAL STRIATUM ; ALCOHOL SEEKING ; DRUG-ADDICTION ; D2 RECEPTORS ; CA(V)1.2 ; MODULATION ; IMPULSIVITY ; PERFORMANCE ; PLASTICITY ; NEURONS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/22295
Collection中国科学院心理健康重点实验室
Corresponding AuthorN. Sui
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lin Cui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Guizhou Normal Univ, Sch Chem & Mat Sci, Guiyang, Guizhou, Peoples R China
Recommended Citation
GB/T 7714
Shen, Fang,Jin, Shubo,Duan, Ying,et al. Distinctive Changes of L-Type Calcium Channels and Dopamine Receptors in the Dorsomedial and Dorsolateral Striatum after the Expression of Habitual Cocaine-Seeking Behavior in Rats[J]. NEUROSCIENCE,2018,370:139-147.
APA Shen, Fang.,Jin, Shubo.,Duan, Ying.,Liang, Jing.,Zhang, Meng.,...&N. Sui.(2018).Distinctive Changes of L-Type Calcium Channels and Dopamine Receptors in the Dorsomedial and Dorsolateral Striatum after the Expression of Habitual Cocaine-Seeking Behavior in Rats.NEUROSCIENCE,370,139-147.
MLA Shen, Fang,et al."Distinctive Changes of L-Type Calcium Channels and Dopamine Receptors in the Dorsomedial and Dorsolateral Striatum after the Expression of Habitual Cocaine-Seeking Behavior in Rats".NEUROSCIENCE 370(2018):139-147.
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