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Altered corticostriatal pathway in first-episode paranoid schizophrenia: Resting-state functional and causal connectivity analyses
Huang, Huan1; Shu, Chang1; Chen, Jun2; Zou, Jilin1; Chen, Cheng1; Wu, Shihao1; Xiao, Ling1,5; Liu, Zhongchun1; Wang, Huiling1,6; Zhou, Yuan3; Wang, Gaohua1,5,7,8; Jiang, Tianzi4; H. Wang; Y. Zhou
2018-02-28
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
Correspondent Emailhlwang@whu.edu.cn ; zhouyuan@psych.ac.cn
ISSN0925-4927
SubtypeArticle
Volume272Pages:38-45
Contribution Rank3
Abstract

Neuroimaging studies suggest the abnormal structure and function of basal ganglion may contribute to the pathophysiology of schizophrenia. However, little is investigated about the both aberrant functional and causal connectivity of striatum in first-episode paranoid schizophrenia (FEPS). Resting-state functional magnetic resonance imaging was used to characterize the functional connectivity (FC) and casual connectivity within the corticostriatal circuit in 31 patients with FEPS and 33 healthy controls. Degree centrality (DC) was used to explore the regions influenced in schizophrenia at the whole-brain level. Subsequently, a seed-based Granger causality analysis was performed to analyze the causal connectivity. We identified reduced DC of the bilateral putamen in the patients, compared to the controls. In the causal connectivity analysis, we found causal dysconnectivity between the putamen and several regions of default mode network, right orbital part of inferior frontal cortex and right fusiform in the patients. Further, the abnormal causal effect was associated with cognitive impairment in FEPS. The present study highlighted the abnormal functional and causal integrity of the striatum in the patients with FEPS during resting state and suggests a potentially implicated role for the cortical-striatal circuit, especially the striatal-default mode network loop, in the pathophysiology of schizophrenia.

DOI10.1016/j.pscychresns.2017.08.003
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational 973 Program of China(2011CB707805) ; National Natural Science Foundation of China(91132301 ; National Science and Technologic Program of China(2015BAI13B02) ; Natural Science Foundation of Hubei Province(2014CFB732) ; 81371476)
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000419835300005
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordMAJOR DEPRESSIVE DISORDER ; DEFAULT-MODE NETWORK ; SALIENCE NETWORK ; STRIATAL DYSFUNCTION ; STRUCTURAL DEFICITS ; UNAFFECTED SIBLINGS ; GRANGER CAUSALITY ; BASAL GANGLIA ; FMRI ; PSYCHOSIS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/22296
Collection社会与工程心理学研究室
Corresponding AuthorH. Wang; Y. Zhou
Affiliation1.Wuhan Univ, Dept Psychiat, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China
2.Wuhan Univ, Dept Radiol, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
5.Hubei Inst Neurol & Psychiat Res, Wuhan 430060, Hubei, Peoples R China
6.Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Hubei, Peoples R China
7.Hubei Univ Sci & Technol, Xianning 437100, Peoples R China
8.Natl Clin Res Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Huang, Huan,Shu, Chang,Chen, Jun,et al. Altered corticostriatal pathway in first-episode paranoid schizophrenia: Resting-state functional and causal connectivity analyses[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2018,272:38-45.
APA Huang, Huan.,Shu, Chang.,Chen, Jun.,Zou, Jilin.,Chen, Cheng.,...&Y. Zhou.(2018).Altered corticostriatal pathway in first-episode paranoid schizophrenia: Resting-state functional and causal connectivity analyses.PSYCHIATRY RESEARCH-NEUROIMAGING,272,38-45.
MLA Huang, Huan,et al."Altered corticostriatal pathway in first-episode paranoid schizophrenia: Resting-state functional and causal connectivity analyses".PSYCHIATRY RESEARCH-NEUROIMAGING 272(2018):38-45.
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