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Following Instructions in Patients With Schizophrenia: The Benefits of Actions at Encoding and Recall
Lui, Simon S. Y.1,2; Yang, Tian-Xiao2,3; Ng, Chris L. Y.1; Wong, Peony T. Y.1; Wong, Jessica O. Y.1; Ettinger, Ulrich4; Cheung, Eric F. C.1; Chan, Raymond C. K.2,5
2018
发表期刊SCHIZOPHRENIA BULLETIN
通讯作者邮箱rckchan@psych.ac.cn
ISSN0586-7614
文章类型Article
卷号44期号:1页码:137-146
产权排序2
摘要

The ability to follow spoken instructions is important to everyday functioning but has seldom been studied in patients with schizophrenia (SZ). Recent evidence suggests that action-based processing may facilitate the ability to follow instructions, which relies largely on working memory. In this study, we tested the hypothesis that SZ patients may also benefit from action-based advantages in following instructions. Forty-eight clinically stable SZ patients and 48 demographic- and IQ-matched controls completed a following spoken instruction span task involving varied encoding and recall conditions. While SZ patients were impaired in the overall performance of following spoken instructions, this deficit could be attributed to working memory impairment. More importantly, SZ patients showed action-based advantages both at the encoding and retrieval stage to the same extent as healthy controls. Specifically, both healthy controls and SZ patients showed improved memory performance when they additionally performed the actions, or watched the experimenter carrying out the actions compared with simply listening to spoken instructions during the encoding stage. During the retrieval stage, memory was improved when they recalled the instructions by physical enactment compared with oral repetition. The present study provides the first empirical evidence for the impairment in the ability to follow instructions in SZ. We have shown that involving action-based processing in the encoding and retrieval stage facilitated memory of instructions, indicating that the enactment advantage in working memory also applies to SZ patients. These findings provide useful insights for clinical interventions and cognitive remediation for SZ patients.

关键词schizophrenia working memory enacted-recall advantage subject-performed task effect experimenter-performed task effect
DOI10.1093/schbul/sbx026
收录类别SCI ; SSCI
语种英语
项目资助者Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Beijing Municipal Science & Technology Commission(Z161100000216138) ; National Basic Research Programme of China(2016YFC0906402) ; CAS key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Programme for Creative Research Teams(Y2CX131003) ; National Natural Science Foundation of China(31400873) ; CAS Key Laboratory of Mental Health, Institute of Psychology(KLMH2015ZG02)
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000422833500018
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]SUBJECT-PERFORMED TASKS ; WORKING-MEMORY ; ACTION EVENTS ; MOTOR ACTION ; ACTION PLANS ; DYSFUNCTION ; PERCEPTION ; ENACTMENT
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/22299
专题中国科学院心理健康重点实验室
作者单位1.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Univ Bonn, Dept Psychol, Bonn, Germany
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Lui, Simon S. Y.,Yang, Tian-Xiao,Ng, Chris L. Y.,et al. Following Instructions in Patients With Schizophrenia: The Benefits of Actions at Encoding and Recall[J]. SCHIZOPHRENIA BULLETIN,2018,44(1):137-146.
APA Lui, Simon S. Y..,Yang, Tian-Xiao.,Ng, Chris L. Y..,Wong, Peony T. Y..,Wong, Jessica O. Y..,...&Chan, Raymond C. K..(2018).Following Instructions in Patients With Schizophrenia: The Benefits of Actions at Encoding and Recall.SCHIZOPHRENIA BULLETIN,44(1),137-146.
MLA Lui, Simon S. Y.,et al."Following Instructions in Patients With Schizophrenia: The Benefits of Actions at Encoding and Recall".SCHIZOPHRENIA BULLETIN 44.1(2018):137-146.
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