PSYCH OpenIR  > 中国科学院心理健康重点实验室
An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene
Zhang, Kunlin1,2; Qu, Susu1,2; Chang, Suhua1,2; Li, Gen1,2; Cao, Chengqi1,2; Fang, Kechi1,2; Olff, Miranda3,4; Wang, Li1,2; Wang, Jing1,2; L. Wang; J. Wang
2017-12-01
Source PublicationNEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Correspondent Emailwangli1@psych.ac.cn ; wangjing@psych.ac.cn
ISSN0149-7634
SubtypeReview
Volume83Pages:647-656
Contribution Rank1
Abstract

Posttraumatic stress disorder (PTSD) is a debilitating psychiatric syndrome with complex etiology. Studies aiming to explore genetic susceptibility and environmental triggers of PTSD have been increasing. However, the results are limited and highly heterogeneous. To understand the genetic study status of PTSD and explore more reliable candidates, we obtained 105 PTSD related genetic studies by comprehensively literature searching and filtering 1762 studies. Detailed phenotype and sample information for each study and association results for each genetic marker were extracted. Based on the extracted data, we reviewed the PTSD genetic research status and further conducted bioinformatics analyses for the genetic data. Our analyses summarized the landscape of PTSD genetic studies, identified the genes with most genetic evidence, discovered the biological function of the candidate variants/genes and enlarged the overall candidates for future investigations. All the data were stored in the PTSDgene database (http://ptsdgene.psych.ac.cn). We hope PTSDgene could be a platform for the rapid growth of PTSD genetic data and provide new insights into the pathogenesis of PTSD.

KeywordPTSD Genetic Gene-environment interaction Database
DOI10.1016/j.neubiorev.2017.08.021
Indexed BySCI
Language英语
Funding OrganizationNational Key Technology Research and Development Program of China(2013BAI08B02) ; National Natural Science Foundation of China(31271099 ; 31471004 ; 31401139)
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000419418700054
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordGENOME-WIDE ASSOCIATION ; NATIONAL COMORBIDITY SURVEY ; DOMAIN CRITERIA RDOC ; LIFETIME PREVALENCE ; MENTAL-DISORDERS ; RECEPTOR GENE ; HPA-AXIS ; RISK ; ENVIRONMENT ; EXPRESSION
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/22300
Collection中国科学院心理健康重点实验室
Corresponding AuthorL. Wang; J. Wang
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Diemen, Netherlands
4.Arq Psychotrauma Expert Grp, Diemen, Netherlands
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Kunlin,Qu, Susu,Chang, Suhua,et al. An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2017,83:647-656.
APA Zhang, Kunlin.,Qu, Susu.,Chang, Suhua.,Li, Gen.,Cao, Chengqi.,...&J. Wang.(2017).An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,83,647-656.
MLA Zhang, Kunlin,et al."An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 83(2017):647-656.
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