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An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene
Zhang, Kunlin1,2; Qu, Susu1,2; Chang, Suhua1,2; Li, Gen1,2; Cao, Chengqi1,2; Fang, Kechi1,2; Olff, Miranda3,4; Wang, Li1,2; Wang, Jing1,2; L. Wang; J. Wang
2017-12-01
发表期刊NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
通讯作者邮箱wangli1@psych.ac.cn ; wangjing@psych.ac.cn
ISSN0149-7634
文章类型Review
卷号83页码:647-656
产权排序1
摘要

Posttraumatic stress disorder (PTSD) is a debilitating psychiatric syndrome with complex etiology. Studies aiming to explore genetic susceptibility and environmental triggers of PTSD have been increasing. However, the results are limited and highly heterogeneous. To understand the genetic study status of PTSD and explore more reliable candidates, we obtained 105 PTSD related genetic studies by comprehensively literature searching and filtering 1762 studies. Detailed phenotype and sample information for each study and association results for each genetic marker were extracted. Based on the extracted data, we reviewed the PTSD genetic research status and further conducted bioinformatics analyses for the genetic data. Our analyses summarized the landscape of PTSD genetic studies, identified the genes with most genetic evidence, discovered the biological function of the candidate variants/genes and enlarged the overall candidates for future investigations. All the data were stored in the PTSDgene database (http://ptsdgene.psych.ac.cn). We hope PTSDgene could be a platform for the rapid growth of PTSD genetic data and provide new insights into the pathogenesis of PTSD.

关键词PTSD Genetic Gene-environment interaction Database
DOI10.1016/j.neubiorev.2017.08.021
收录类别SCI
语种英语
项目资助者National Key Technology Research and Development Program of China(2013BAI08B02) ; National Natural Science Foundation of China(31271099 ; 31471004 ; 31401139)
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000419418700054
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]GENOME-WIDE ASSOCIATION ; NATIONAL COMORBIDITY SURVEY ; DOMAIN CRITERIA RDOC ; LIFETIME PREVALENCE ; MENTAL-DISORDERS ; RECEPTOR GENE ; HPA-AXIS ; RISK ; ENVIRONMENT ; EXPRESSION
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/22300
专题中国科学院心理健康重点实验室
通讯作者L. Wang; J. Wang
作者单位1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Diemen, Netherlands
4.Arq Psychotrauma Expert Grp, Diemen, Netherlands
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Zhang, Kunlin,Qu, Susu,Chang, Suhua,et al. An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2017,83:647-656.
APA Zhang, Kunlin.,Qu, Susu.,Chang, Suhua.,Li, Gen.,Cao, Chengqi.,...&J. Wang.(2017).An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,83,647-656.
MLA Zhang, Kunlin,et al."An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 83(2017):647-656.
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