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Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia
Chan, Raymond C. K.1,2,3; Cui, Hui-ru4; Chu, Min-yi1; Zhang, Tian-hong4; Wang, Ya2; Wang, Yi2; Li, Zhi2,3; Lui, Simon S. Y.2,5; Wang, Ji-jun4; Cheung, Eric F. C.5; Raymond C. K. Chan
2018-02-01
发表期刊EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
通讯作者邮箱rckchan2003@yahoo.com.hk; rckchan@psych.ac.cn
ISSN0940-1334
文章类型Article
卷号268期号:1页码:49-56
产权排序2
摘要

Neurological soft signs (NSS) are one of the biomarkers for schizophrenia spectrum disorders. However, a few studies have examined the prevalence of NSS across the schizophrenia spectrum. The present study adopted a quasi-longitudinal study design and examined the prevalence of NSS and their associations with clinical and behavioural manifestations in participants in different stages of the illness. The abridged version of the Cambridge Neurological Inventory was administered to 39 patients with the first-episode schizophrenia, 39 individuals with ultra-high risk (UHR) for psychosis, 39 individuals with schizotypy, and 39 healthy controls. Patients with the first-episode schizophrenia had a higher prevalence of NSS in motor coordination than healthy controls as well as individuals with UHR and schizotypy. Individuals with UHR exhibited a higher prevalence of sensory integration items than individuals with schizotypy and healthy controls. Discriminant analysis classified the membership of the individuals correctly across the spectrum with an accuracy of up to 60.9%. In particular, NSS could discriminate individuals with UHR from healthy controls at up to 85.9% accuracy. These findings suggest that NSS are robust biomarkers to detect and discriminate individuals in different stages of the schizophrenia spectrum from healthy controls.

关键词Schizophrenia Psychosis Psychopathology Neurological signs
DOI10.1007/s00406-017-0828-4
收录类别SCI ; SSCI
语种英语
项目资助者National Basic Research Programme of China (Precision Psychiatry Program)(2016YFC0906402) ; Beijing Municipal Science and Technology Commission(Z161100000216138) ; Beijing Training Project for the Leading Talents in S and T(Z151100000315020) ; Science Foundation of Shanghai Mental Health Centre(SMHCRSD01)
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Clinical Neurology ; Psychiatry
WOS记录号WOS:000423103700006
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]1ST-EPISODE SCHIZOPHRENIA ; BIPOLAR DISORDER ; FOLLOW-UP ; PSYCHOSIS ; ABNORMALITIES ; DYSFUNCTION ; FEATURES ; SCALE ; ENDOPHENOTYPES ; ADOLESCENTS
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/22304
专题中国科学院心理健康重点实验室
通讯作者Raymond C. K. Chan
作者单位1.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Translat Neuropsychol & Appl Cognit Neurosci Lab, Sch Med, 600 Wanping South Rd, Shanghai 200030, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai, Peoples R China
5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Chan, Raymond C. K.,Cui, Hui-ru,Chu, Min-yi,et al. Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2018,268(1):49-56.
APA Chan, Raymond C. K..,Cui, Hui-ru.,Chu, Min-yi.,Zhang, Tian-hong.,Wang, Ya.,...&Raymond C. K. Chan.(2018).Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,268(1),49-56.
MLA Chan, Raymond C. K.,et al."Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 268.1(2018):49-56.
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