| Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder | |
| WeiLi1; HuiruCui1; ZhipeiZhu1; LiKong2; QianGuo1; YikangZhu1; QiangHu3; Lanlan Zhang4; HuiLi1; QingweiLi5; JianglingJiang1; JordanMeyers6; JianqiLi7; Jijun Wang1,8,9; ZhiYang10; ChunboLi1,8,9; JijunWang; Zhi Yang | |
| 通讯作者邮箱 | jijunwang27@163.com ; yangz@psych.ac.cn ; chunbo_li@163.com |
| 摘要 | The amygdala and the dorsolateral prefrontal cortex (DLPFC) play important roles in “emotion dysregulation,” which has a profound impact on etiologic research of generalized anxiety disorder (GAD). The present study analyzed both eyes-open and eyes-closed resting state functional MRI (rs-fMRI) of 43 subjects (21 GAD patients with medicine free and 22 matched healthy controls). The amygdala and the DLPFC were defined as regions of interest (ROI) to analyze functional connectivity (FC) in GAD patients compared with healthy controls. The main findings revealed GAD patients had increased FC between the amygdala and the temporal pole compared to healthy controls, which was found in both eyes-open and eyes-closed rs-fMRI. And altered FC between the ROIs and brain regions that mainly belonged to the default mode network (DMN) were found. These findings suggest that the abnormal FC between the amygdala and the temporal pole may contribute to the pathophysiology of GAD, and provide insights into the current understanding of the emotion dysregulation of anxiety disorders. |
| 关键词 | amygdala DLPFC temporalpole DMN functionalconnectivity generalizedanxietydisorder |
| 2016 | |
| 语种 | 英语 |
| 发表期刊 | Human Neuroscience
 |
| 卷号 | 10期号:0页码:1-9 |
| 收录类别 | SCI |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/22362 |
| 专题 | 健康与遗传心理学研究室 |
| 通讯作者 | ChunboLi; JijunWang; Zhi Yang |
| 作者单位 | 1.Shanghai KeyLaboratoryofPsychoticDisorders,ShanghaiMentalHealthCenter,ShanghaiJiaoTongUniversitySchoolof Medicine, Shanghai,China 2.CollegeofEducation,ShanghaiNormalUniversity,Shanghai,China 3.Departmentof Psychology,QiqiharMentalHealthCenter,Qiqihar,China, 4.Guangji HospitalofSuzhou,Suzhou,China 5.Departmentof Psychiatry,TongjiHospitalofTongjiUniversity,Shanghai,China, 6.NathanS.KlineInstituteforPsychiatricResearch,New York,NY,USA 7.Shanghai KeyLaboratoryofMagneticResonance,DepartmentofPhysics,EastChinaNormalUniversity, Shanghai, China, 8.Key LaboratoryfortheGeneticsofDevelopmentalandNeuropsychiatricDisorders,Bio-XInstitutes, MinistryofEducation,ShanghaiJiaoTongUniversity,Shanghai,China 9.Brain ScienceandTechnologyResearchCenter, Shanghai JiaoTongUniversity,Shanghai,China, 1 10.CASKeyLaboratoryofBehavioralScienceandMRIResearchCenter, Institute ofPsychology,ChineseAcademyofSciences,Beijing,China |
| 推荐引用方式 GB/T 7714 | WeiLi,HuiruCui,ZhipeiZhu,et al. Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder[J]. Human Neuroscience,2016,10(0):1-9. |
| APA | WeiLi.,HuiruCui.,ZhipeiZhu.,LiKong.,QianGuo.,...&Zhi Yang.(2016).Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder.Human Neuroscience,10(0),1-9. |
| MLA | WeiLi,et al."Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder".Human Neuroscience 10.0(2016):1-9. |
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| Aberrant Functional （894KB） | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 | |
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