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Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder
WeiLi1; HuiruCui1; ZhipeiZhu1; LiKong2; QianGuo1; YikangZhu1; QiangHu3; Lanlan Zhang4; HuiLi1; QingweiLi5; JianglingJiang1; JordanMeyers6; JianqiLi7; Jijun Wang1,8,9; ZhiYang10; ChunboLi1,8,9; JijunWang; Zhi Yang
2016
Source PublicationHuman Neuroscience
Correspondent Emailjijunwang27@163.com ; yangz@psych.ac.cn ; chunbo_li@163.com
Volume10Issue:0Pages:1-9
Abstract

The amygdala and the dorsolateral prefrontal cortex (DLPFC) play important roles in “emotion dysregulation,” which has a profound impact on etiologic research of generalized anxiety disorder (GAD). The present study analyzed both eyes-open and eyes-closed resting state functional MRI (rs-fMRI) of 43 subjects (21 GAD patients with medicine free and 22 matched healthy controls). The amygdala and the DLPFC were defined as regions of interest (ROI) to analyze functional connectivity (FC) in GAD patients compared with healthy controls. The main findings revealed GAD patients had increased FC between the amygdala and the temporal pole compared to healthy controls, which was found in both eyes-open and eyes-closed rs-fMRI. And altered FC between the ROIs and brain regions that mainly belonged to the default mode network (DMN) were found. These findings suggest that the abnormal FC between the amygdala and the temporal pole may contribute to the pathophysiology of GAD, and provide insights into the current understanding of the emotion dysregulation of anxiety disorders.

Keywordamygdala DLPFC temporalpole DMN functionalconnectivity generalizedanxietydisorder
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/22362
Collection健康与遗传心理学研究室
Corresponding AuthorChunboLi; JijunWang; Zhi Yang
Affiliation1.Shanghai KeyLaboratoryofPsychoticDisorders,ShanghaiMentalHealthCenter,ShanghaiJiaoTongUniversitySchoolof Medicine, Shanghai,China
2.CollegeofEducation,ShanghaiNormalUniversity,Shanghai,China
3.Departmentof Psychology,QiqiharMentalHealthCenter,Qiqihar,China,
4.Guangji HospitalofSuzhou,Suzhou,China
5.Departmentof Psychiatry,TongjiHospitalofTongjiUniversity,Shanghai,China,
6.NathanS.KlineInstituteforPsychiatricResearch,New York,NY,USA
7.Shanghai KeyLaboratoryofMagneticResonance,DepartmentofPhysics,EastChinaNormalUniversity, Shanghai, China,
8.Key LaboratoryfortheGeneticsofDevelopmentalandNeuropsychiatricDisorders,Bio-XInstitutes, MinistryofEducation,ShanghaiJiaoTongUniversity,Shanghai,China
9.Brain ScienceandTechnologyResearchCenter, Shanghai JiaoTongUniversity,Shanghai,China, 1
10.CASKeyLaboratoryofBehavioralScienceandMRIResearchCenter, Institute ofPsychology,ChineseAcademyofSciences,Beijing,China
Recommended Citation
GB/T 7714
WeiLi,HuiruCui,ZhipeiZhu,et al. Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder[J]. Human Neuroscience,2016,10(0):1-9.
APA WeiLi.,HuiruCui.,ZhipeiZhu.,LiKong.,QianGuo.,...&Zhi Yang.(2016).Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder.Human Neuroscience,10(0),1-9.
MLA WeiLi,et al."Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder".Human Neuroscience 10.0(2016):1-9.
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