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Abstinent Heroin Addicts Tend to Take Risks ERP and Source Lolecalization
Qinglin Zhao1; Hongqian Li1; Bin Hu1; Haiyan Wu2,3; Quanying Liu4,5
Source PublicationNEUROSCIENCE
Correspondent ;

Abnormal decision making is a behavioral characteristic of drug addiction. Indeed, drug addicts prefer immediate rewards at the expense of future interests. Assessing the neurocognitive basis of decision-making related to drug dependence, combining event-related potential (ERP) analysis and source localization techniques, may provide new insights into understanding decision-making deficits in drug addicts and further guide withdrawal treatment. In this study, EEG was performed in 20 abstinent heroin addicts (AHAs) and 20 age-, education- and gender-matched healthy controls (HCs) while they participated in a simple two-choice gambling task (99 vs. 9). Our behavioral results showed that AHAs tend to select higher-risk choices compared with HCs (i.e., more “99” choices than “9”). ERP results showed that right hemisphere preponderance of stimulus-preceding negativity was disrupted in AHAs, but not in HCs. Feedback-related negativity of difference wave was higher in AHAs than HCs, with the P300 amplitude associated with risk magnitude and valence. Using source localization that allows identification of abnormal brain activity in consequential cognitive stages, including the reward expectation and outcome evaluation stages, we found abnormalities in both behavioral and neural responses on gambling in AHAs. Taken together, our findings suggest AHAs have risk-prone tendency and dysfunction in adaptive decision making, since they continue to choose risky options even after accruing considerable negative scores, and fail to shift to a safer strategy to avoid risk. Such abnormal decision-making bias to risk and immediate reward seeking may be accompanied by abnormal reward expectation and evaluation in AHAs, which explains their high risk-seeking and impulsivity.

Keywordgambling task decision making ERP stimulus preceding negativity feedback related negativity P300 source localization heroin addiction
Indexed BySCI
Document Type期刊论文
Corresponding AuthorBin Hu; Quanying Liu
Affiliation1.Ubiquitous Awareness and Intelligent Solutions Lab, Lanzhou University, Lanzhou, China
2.Institute of Psychology, Chinese Academy of Sciences, Beijing, China
3.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
4.Movement Control & Neuroplasticity Research Group, KU Leuven, Leuven, Belgium
5.Neural Control of Movement Laboratory, ETH Zurich, Zurich, Switzerland
Recommended Citation
GB/T 7714
Qinglin Zhao,Hongqian Li,Bin Hu,et al. Abstinent Heroin Addicts Tend to Take Risks ERP and Source Lolecalization[J]. NEUROSCIENCE,2017(6):1-12.
APA Qinglin Zhao,Hongqian Li,Bin Hu,Haiyan Wu,&Quanying Liu.(2017).Abstinent Heroin Addicts Tend to Take Risks ERP and Source Lolecalization.NEUROSCIENCE(6),1-12.
MLA Qinglin Zhao,et al."Abstinent Heroin Addicts Tend to Take Risks ERP and Source Lolecalization".NEUROSCIENCE .6(2017):1-12.
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