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大鼠抑郁障碍参与启动心血管组织NFкB表达增强
Alternative TitleDepressivedisorderincreasesexpressionofNF-κBinratvesseltissue
陈莹1; 常志文1; 杨琳4; 翟艳苓2; 张勇3; 林文娟5
2011
Source Publication基础医学与临床
Correspondent Emailwinnie2003619@sina.com
ISSN基础医学与临床
Volume31Issue:6Pages:700-703
Abstract

目的 探讨强迫游泳抑郁模型大鼠抑郁障碍与炎性标记物的相关性.方法 健康SD大鼠随机分为对照组和模型组,应用21 d强迫游泳实验建立大鼠抑郁模型,模型组大鼠包括SS组(应激+0.9氯化钠注射液腹腔注射)和SI组(应激+丙米嗪腹腔注射).应用透射免疫比浊法和酶联免疫法检测外周血炎性标记物hsCRP、MCP-1水平,应用免疫组织化学染色法检测血管组织NF-кB P65、MCP-1表达.结果 应激后外周血hsCRP和MCP-1含量明显高于对照组(P<0.05),血管组织中MCP-1为35.6±7.5,NF-кB P65为31.2±6.5,表达显著增强(P<0.05),药物干预组外周血MCP-1显著回降(P<0.05),血管组织炎性标志物表达减少.结论 抑郁障碍通过NF-кB表达增强进而启动炎性反应.

Other Abstract

Abstract:ObjectiveToinvestigatetherelationshipbetweendepressivedisorderandinflammationmarkersindepressiveratsinducedbyForcedSwimmingTest(FST).Methods  SDratswererandomlydividedintocontrolling groupsandmodellinggroups, DepressionanimalmodelwasreproducedwithFSTin21days.ModelinggroupincludedSSgroup(FSTratswith0.9% sodiumcloridetreated)andSIgroup(FSTratswithimipraminetreated). allperipheralbloodserumsampleswererespectivelymeasuredusingenzymelinkedimmunoassay(ELISA)techniqueforconcentrationofMCP-1 andimmunoturbidimetricassayforhsCRP.TheexpressionofMCP-1 andNF-κBP65 inaortatissuewereobservedbyimmunohistochemistry.Results Therewasahighlevelofconcentrationof hsCRPandMCP-1 inperipheralbloodserumsamplesandincreasedexpressionofMCP-1 andNF-κBP65 inaorta tissueofSSgroups(P<0.05).Sigroupshaddecreasedtheexpressionofinflammationmarkersinbloodandaorta tissue.Conclusion DepressivedisorderactivatetheinflammatoryreactionthroughincreasedexpressionofNF-κB.

Keyword冠心病 抑郁症 Nf-κbp65 Mcp-1 实验动物模型
DOI10.16352/j.issn.1001-6325.2011.06.020
Indexed ByCSCD
Language中文
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25133
Collection健康与遗传心理学研究室
Affiliation1.首都医科大学附属北京同仁医院干部医疗科
2.首都医科大学肝细胞实验室
3.首都医科大学附属北京同仁医院血液科
4.首都医科大学附属北京同仁医院病理科
5.中国科学院心理研究所
Recommended Citation
GB/T 7714
陈莹,常志文,杨琳,等. 大鼠抑郁障碍参与启动心血管组织NFкB表达增强[J]. 基础医学与临床,2011,31(6):700-703.
APA 陈莹,常志文,杨琳,翟艳苓,张勇,&林文娟.(2011).大鼠抑郁障碍参与启动心血管组织NFкB表达增强.基础医学与临床,31(6),700-703.
MLA 陈莹,et al."大鼠抑郁障碍参与启动心血管组织NFкB表达增强".基础医学与临床 31.6(2011):700-703.
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