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Alternative TitleDifferential effects of early environmental enrichment on spatial learning and memory of wild house mouse and Kunming mouse
李春禄1; 张佳婧2; 王冬梅1; 李勇辉1
Source Publication中华行为医学与脑科学杂志
Contribution Rank1


Other Abstract

Objective To evaluate and compare the effect of early environmental enrichment on spatial learning and memory in wild house mouse and Kunming mouse, one kind of laboratory mouse which evolved from wild house mouse. Methods The wild house mouse F1 generation were employed to control the environmental enrichment . Offspring were weaned on PND22 and housed in usual or rich environment for one month randomly, then engaged the morris maze: house mouse rich environment( n = 7 ) , house mouse poor environment ( n = 6 ) , Kunming mouse rich environment( n= 10) ,Kunming mouse poor environment( n= 10). Results (1) Early environmental enrichment improve the performance of house mouse ( poor environment : ( 39.5 ± 3.8 ) s ; rich environment : (25.2 ±4.5 ) s; F(1,22) = 8.115, P 〈 0.01 ), but had no effect on that of Kunming mouse in tests of spatial memory ( poor environment : ( 8.5 ± 2.4) s ; rich environment : (7.5 ± 1.7 ) s ; F(1,36) = 0. 149, P = 0. 702). (2) Early environmental enrichment improve the performance of house mouse ( F(1,132) = 15. 307, P〈 0.01 )and Kunming mouse ( F(1,216) = 8. 701, P 〈 0.01 )in spatial learn session. Conclusion The wild house mouse is more sensitive to the enrich environment than laboratory mouse. Therefore, it has higher validity of model.

Keyword丰富环境 野生小家鼠 昆明小鼠 水迷宫 学习记忆
Indexed ByCSCD
Funding Organization国家自然科学基金项目(31070911) ; 国家973计划重点基础研究发展计划项目(2009CB522002)
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Cited Times:4[CSCD]   [CSCD Record]
Document Type期刊论文
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GB/T 7714
李春禄,张佳婧,王冬梅,等. 丰富环境对野生小家鼠和昆明小鼠空间学习记忆能力的影响[J]. 中华行为医学与脑科学杂志,2011,20(7):共3页.
APA 李春禄,张佳婧,王冬梅,&李勇辉.(2011).丰富环境对野生小家鼠和昆明小鼠空间学习记忆能力的影响.中华行为医学与脑科学杂志,20(7),共3页.
MLA 李春禄,et al."丰富环境对野生小家鼠和昆明小鼠空间学习记忆能力的影响".中华行为医学与脑科学杂志 20.7(2011):共3页.
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