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Alternative TitleNeurobiological mechanisms involved in the development of compulsive drug use
段颖1,2; 沈芳1; 隋南1
Source Publication科学通报


Other Abstract

Compulsive drug use, or continual drug use despite punishment, is the core symptom of addiction. Drug addiction is associated with a shift from the response-outcome (R-O) process to the stimulus-response (S-R) process, such that it becomes habitual and ultimately compulsive. Previous studies have shown that this shift represents a transition at the neural level from ventral to more dorsal domains of the stdatum, which is mediated by dopaminergic circuitry. However, a recent study indicated novel differentiation in dorsal striatum function. The midlateral striatum is involved in all stages of drug seeking after chronic self-administration training, whereas the dorsolateral striatum selectively participates in compulsive drug seeking. In addition, there is increasing evidence that chronic drug use can damage the prefrontal cortex. Indeed, different glutamatergic projections from the prefrontal cortex to the striatum play competing roles in drug seeking. These neural transitions depend on molecular mechanisms of neuroplasticity. An increasing number of studies have shown that low levels of D2 receptors predict a switch to compulsive drug use. Additionally, recent studies indicated that 5-hydroxytryptamine also plays an important role in compulsive drug use.

Keyword强迫性用药行为 背侧纹状体 前额叶皮层 D2多巴胺受体 五羟色胺
Indexed ByCSCD
Funding Organization国家自然科学基金(31170988) ; 国家自然科学基金重大研究计划培育项目(91332115) ; 国家重点基础研究发展计划(2014CB553500) ; 中国博士后基金(2014M550869)资助
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Document Type期刊论文
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
段颖,沈芳,隋南. 强迫性用药行为的神经生物学机制研究进展[J]. 科学通报,2015,60(13):1160–1166.
APA 段颖,沈芳,&隋南.(2015).强迫性用药行为的神经生物学机制研究进展.科学通报,60(13),1160–1166.
MLA 段颖,et al."强迫性用药行为的神经生物学机制研究进展".科学通报 60.13(2015):1160–1166.
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