健康与遗传心理学研究室知识库

目的评价中国普通人群1982-2012年焦虑障碍患病率及其在性别、年龄、城乡、婚姻状况、教育程度、调研年代、诊断标准等不同因素间的差别。方法检索EMBASE、PubMed和中国期刊全文数据库、万方数字化期刊全文数据库、中国科技期刊数据库(维普)、中国生物医学文献数据库等,并辅以文献追溯方法,收集1982-2012年在国内外公开发表的所有关于中国人群焦虑障碍患病率的研究文献,依照事先定义的纳入及排除标准进行筛选,并根据观察性研究的报告标准评价文献质量,采用R-2.15.0软件对资料间异质性检验、敏感性分析、合并患病率及发表偏倚评估进行Meta分析。结果共25项研究196020人纳入分析。焦虑障碍时点患病率为1.0%[95%可信区间(CI)0.7%-1.4%],12个月患病率为4.5%(95%CI2.7%-7.5%),终生患病率为3.2%(95%CI2.1%-4.7%)。以时点患病率计,广泛性焦虑障碍患病率为0.6%(95%CI0.4%~0.9%),惊恐障碍为0.2%(95%CI0.1%-0.4%);青壮年人群焦虑障碍患病率为1.3%(95%CI0.3%-4.7%),中年人群为3.0%(95%CI1.2%-7.4%),老年人群为7.1%(95%CI5.4%-9.2%);城市焦虑障碍患病率为2.8%(95%CI1.1%~7.5%),农村地区为2.9%(95%CI1.5%~5.6%);1982--1992年的研究焦虑障碍患病率合并为0.3%(95%CI0.1%~0.6%),1993-2000年为0.5%(95%CI0.2%-1.1%),2001年后为2.8%(95%CI2.1%~3.8%);应用国内诊断标准的焦虑障碍患病率为0.3%(95%CI0.1%-0.8%),国外/国际诊断标准为3.2%(95%CI2.3%-4.4%);观察性流行病学研究报告规范评分结果为(14.36±3.17)分。结论中国普通人群焦虑障碍总患病率较低,但研究报告总体水平有待进一步提高;中老年人群、2001年后的调研、应用《国际疾病分类标准》及《美国精神障碍诊断与统计手册》诊断系统的患病率相对较高。

Objective To evaluate the prevalence of anxiety disorder among China mainland residents in studies published from 1982 to 2012 through meta-analysis. Methods According to pre-defined selection criteria and exclusion criteria, epidemiological studies published during 1982 to 2012, on anxiety disorders among mainland general population in China were identified through searching Chinese Biological Medical Literature Database, Chongqing VIP database for Chinese Technical Periodicals, Wanfang Database, Chinese National Knowledge Infrastructure, EMBASE and PubMed. Hand searches of cross references were also conducted for further references. The quality of included studies were evaluated by Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). R-2. 15.0 software was employed for statistical analysis. Results Twenty-five studies were included ( a total of 196 020 people). The overall point prevalence of anxiety disorder was 1.0% ( 95% CI 0. 7% - 1.4% ), twelve-month prevalence was 4. 5% (95% CI 2. 7% - 7.5% ), and lifetime prevalence was 3.2% (95% CI 2. 1% - 4. 7% ). The point prevalence of generalized anxiety disorder and panic disorder were 0. 6% ( 95% CI 0. 4% - 0. 9% ) and 0. 2% (95% CI 0. 1% - 0. 4% ) respectively. The pooled prevalence rates were 1.3% (95% CI 0. 3% -4. 7% ) for the young and 3.0% (95% CI 1.2% -7.4% ) for the middle-aged and 7.1% (95% CI 5.4% - 9. 2% ) for older adults. The rates for urban and rural were 2. 8% (95% CI 1.1% -7.5% ) and 2.9% (95 % CI 1.5 % -5.6% ). The prevalence during 1982 to 1992 survey was 0. 3 % (95 % CI 0. 1% -0. 6% ), during 1993 to 2000 was 0.5%(95%CI0.2% -1.1%) and after 2001 was 2. 8% (95%C12.1% - 3.8% ). The prevalence according to different diagnostic criteria were 0. 3% (95% CI 0. 1% -0. 8% ) for CCMD and 3.2% (95% C1 2. 3% - 4.4% ) for ICD or DSM. Included studies were assessed by STROBE criteria, the average score was 14. 36 (SD = 3.17 ). Conclusions Compared with other countries, the overall prevalence of anxiety disorder is lower in China. Middle aged and elderly may be risk factors, The prevalence in studies conducted after 2001 and with the criteria of ICD or DSM is higher. The quality of reporting needs further improvement.